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Journal of Education, Health and Sport

Changes of non-specific resistance in patients with postoperative peritonitis with abdominal sepsis
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Changes of non-specific resistance in patients with postoperative peritonitis with abdominal sepsis

Authors

  • M. M. Droniak Ivano-Frankivsk National Medical University

DOI:

https://doi.org/10.12775/JEHS.2021.11.03.022

Keywords

Postoperative peritonitis, abdominal sepsis

Abstract

Purpose: to study changes in nonspecific resistance and cytokine regulation in patients with postoperative peritonitis with abdominal sepsis

Materials and methods. The clinic treated 456 patients with postoperative peritonitis who were treated in the surgery department of the municipal non-profit enterprise Regional Clinical Hospital of Ivano-Frankivsk Regional Council in the period from 2000 to 2021. Immunological studies were performed in 66 patients with varying severity of abdominal sepsis and its complications.

Research results and their discussion. In patients with postoperative peritonitis with abdominal sepsis, the phagocytic index during the first week of hospital stay was in control. However, on the 10th-11th day, the phagocytic index decreased 1.6 times, which progressed until the end of the third week of treatment - on the 14th-21st day, the phagocytic index was 2.7 times smaller than the control. The phagocytic count in patients with PP with abdominal sepsis reached maximum values in the first day of the disease (3 ± 0.26). Later in the treatment process, this figure gradually decreased and on day 14-21 came to normal and amounted to 1.96 ± 0.10. The index of completeness of phagocytosis on the first day of the disease was1,59 ± 0,20. By 2-3 days it decreased by 1.44 ± 0.20 and returned to normal by 14-21 days. Circulating immune complexes were normalized by 5-7 days of the disease.

References

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Posadas-Calleja JG, Stelfox HT, Ferland A, Zuege DJ, Niven DJ, Berthiaume L, Doig CJ. Derivation of a PIRO Score for Prediction of Mortality in Surgical Patients With Intra-Abdominal Sepsis. Am J Crit Care. 2018; 27(4): 287-294.

Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017; 43(3): 304–77.

Sartelli M, Griffiths E, Nestori M. The challenge of post-operative peritonitis after gastrointestinal surgery. Updates in Surgery. 2015; 67(4): 373-381.

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Tokunaga M, Tanizawa Y, Bando E, et al. Poor survival rate in patients with postoperative intra-abdominal infectious complications following curative gastrectomy for gastric cancer. Annals of Surgical Oncology. 2013; 20: 1575–1583.

Torer N, Yorganci K, Elker D, Sayek I. Prognostic factors of the mortality of postoperative intraabdominal infections. Infection. 2010; 38(4):255–260

Wang HH, Huang CH, Kuo MC, Lin SY, Hsu CH, Lee CY, et al. Microbiology of peritoneal dialysis-related infection and factors of refractory peritoneal dialysis related peritonitis: A ten-year single-center study in Taiwan. Journal of microbiology immunology and infection. 2019; 52(5): 752-759.

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Published

2021-03-31

How to Cite

1.
DRONIAK, M. M. Changes of non-specific resistance in patients with postoperative peritonitis with abdominal sepsis. Journal of Education, Health and Sport [online]. 31 March 2021, T. 11, nr 3, s. 231–238. [accessed 29.3.2023]. DOI 10.12775/JEHS.2021.11.03.022.
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Vol. 11 No. 3 (2021)

Section

Research Articles

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