Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

Prevention of preeclampsia in pregnant women with obesity
  • Home
  • /
  • Prevention of preeclampsia in pregnant women with obesity
  1. Home /
  2. Archives /
  3. Vol. 11 No. 3 (2021) /
  4. Research Articles

Prevention of preeclampsia in pregnant women with obesity

Authors

  • Marta Zelinka-Khobzey Ukrainian Medical Stomatological Academy
  • Kostiantyn Tarasenko Ukrainian Medical Stomatological Academy
  • Tatyana Mamontova Ukrainian Medical Stomatological Academy
  • Oksana Shlykova Ukrainian Medical Stomatological Academy

DOI:

https://doi.org/10.12775/JEHS.2021.11.03.018

Keywords

vascular endothelial growth factor, circulating endothelial microparticles CD32 CD40 , endothelial dysfunction, preeclampsia, pregnancy, obesity

Abstract

Reducing the occurrence of preeclampsia is one of the key tasks in modern obstetrics, especially in pregnant women with concomitant obesity, who are at high risk for preeclampsia, the leading pathogenetic segment of which is endothelial dysfunction. The purpose of this work is to evaluate the effectiveness of the integrated therapeutic and preventive complex (TPC) in order to prevent preeclampsia in pregnant women. These parameters were evaluated using such markers as the concentration of vascular endothelial growth factor (VEGF) in blood serum and the content of circulating endothelial microparticles (CEM) CD32+CD40+ in peripheral blood in pregnant women with obesity of varying severity over the course of treatment we proposed. 110 pregnant women were included in the study: women with physiological body weight (n=26); women with class I obesity (n=42), and women with class II-III obesity. The groups of pregnant women with concomitant obesity were divided into two equal subgroups; one of the subgroups received the TPC (acetylsalicylic acid, calcium supplements, L-arginine, diosmin). The findings obtained demonstrate a significant improvement of endothelial status over the course of the therapy that is manifested with an increase in the serum VEGF concentration and a decrease in the content of CD32+CD40+ CEM in the peripheral blood. Our clinical assessment of pregnancy course, childbirth and the postpartum period in women with obesity and physiological body weight has shown a decrease in the occurrence of complications due to taking the integrated TPC. We have registered a decrease in the incidence of preeclampsia, placental dysfunction, occurrence of miscarriage, operative delivery and postpartum complications.

References

Chooi Y.C., Ding С., Magkos F. The epidemiology of obesity. Metabolism. 2019; 92: 6-10. https://doi.org/10.1016/j.metabol.2018.09.005.

Коrytko, О. О. Vplyv nadmirnoi masy tila ta ozhyrinnia na fertylnist i vynoshuvannia vahitnosti [Influence of overweight and obesity on reproductive health and carrying of a pregnancy]. International journal of endocrinology. 2016; 7: 22-26 (in Ukrainian). http://dx.doi.org/10.22141/22240721.7.79.2016.86415.

Christians J.K., Huicochea Munoz M.F. Pregnancy complications recur independently of maternal vascular malperfusion lesions. PLOS ONE. https://doi.org/10.1371/journal.pone.0228664 February 6, 2020.

Spradley F.T., Palei A.C., Granger J.P. Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms. Am J Physiol Regul Integr Comp Physiol. 2015; 309 (11): 1326-1343. https://doi.org/10.1152/ajpregu.00178.2015

Mochan S., Dhingra M., Gupta S., Saxena S., Arora P., Yadav V., Rani N., et al. Status of VEGF in preeclampsia and its effect on endoplasmic reticulum stress in placental trophoblast cells. European Journal Of Obstetrics & Gynecology And Reproductive Biology: X. 2019; 4: 100070. https://doi.org/10.1016/j.eurox.2019.100070

Amosco M.D., Villar V.A., Naniong J.M., David-Bustamante L.M., Jose P.A., Palmes-Saloma C.P. VEGF-A and VEGFR1 SNPs associate with preeclampsia in a Philippine population. Clin Exp Hypertens. 2016; 38 (7): 578-585. https://doi.org/10.3109/10641963.2016.1174252

Kutsenko N.L., Savchenko L.G., Kaydasheva E.I., Kutsenko L.A., Solochina I.L., Kaydashev I.P. Determination of circulating CD32+ CD40+- microparticles - modification of degradation assessment of endothelial cells. Clinical Laboratory Dіagnostics. 2011; 7: 20-23.

Berezin A.E. The endothelial progenitor cell dysfunction in hypertension: the diagnostic and predictive values. Vessel Plus. 2018; 2: 22. http://dx.doi.org/10.20517/2574-1209.2018.23

Camarena Pulido E.E., García Benavides L., Panduro Barón J.G., Pascoe Gonzalez S, Madrigal Saray A.J., Garcia Padilla F. E, et al. Efficacy of L-arginine for preventing preeclampsia in high-risk pregnancies: a double-blind, randomized, clinical trial. Hypertens Pregnancy. 2016; 35 (2): 217-225. https://doi.org/10.3109/10641955.2015.1137586

Lakhno I. Sovremennye vozmozhnosti prognozirovanija i profilaktiki prejeklampsii [Modern possibilities of prediction and prevention of preeclampsia]. Zdorov'e zhenshhiny. 2016; 7 (113): 44-48 (in Russian). https://doi.org/10.15574/HW.2016.113.44

Lutsenko, N., (1986). Beremennost' i rody u zhenshhin s ozhireniem. [Pregnancy and childbirth in women with obesity]. Health. 112 p. [in Russian].

Butalia S., Audibert F., Côté A.M., Firoz T., Logan A.G., Magee L.A., et al. Hypertension Canada's Guidelines for the Management of Hypertension in Pregnancy. Canadian Journal of Cardiology. 2018; 34 (5): 526-531. https://doi.org/10.1016/j.cjca.2018.02.021.

Syusyuka V., Kolokot G., Belenichev I. Otsiniuvannia vplyvu kompleksnoi terapii vahitnykh iz zatrymkoiu rostu ploda na akusherski ta perynatalni naslidky rozrodzhennia. [Evaluation of the influence of complex therapy of pregnant women with fetal growth retardation on obstetric and perinatal consequences of childbirth]. Zdorovia zhinky. 2019; 10 (146): 55-61 (in Ukrainian). https://doi.org/10.15574/HW.2019.146.55

Shashar M., Chernichovski T., Pasvolsky O., Levi Sh., Grupper A., Hershkovitz R., Weinstein T. Vascular Endothelial Growth Factor Augments Arginine Transport and Nitric Oxide Generation via a KDR Receptor Signaling Pathway. Kidney Blood Press Res. 2017; 42: 201-208. https://doi.org/10.1159/000476016

Vaschenko V., Likhachov V., Dobrovolska L., Taranovska, O. Vplyv vtorynnoi profilaktyky rozvytku preeklampsii u zhinok hrupy vysokoho ryzyku na pokaznyky fetoplatsentarnoho krovotoku [Effect of secondary prevention of preeclampsia on fetoplacental blood flow rates in highrisk women]. Vistnyk problem biolohii i medytsyny. 2020; 3 (1): 94-97 (in Ukrainian). https://doi.org/10.29254/2077-4214-2020-3-157-94-97

Gopchuk E.N. Vozmozhnosti ispol'zovanija l-arginina v akusherstve i ginekologii dlja lechenija patologij, vyzvannyh jendotelial'noj disfunkciej. [Possibilities of using l-arginine in obstetrics and gynecology for the treatment of pathologies caused by endothelial dysfunction]. Zdorov'e zhenshhiny. 2017; 2(118): 50-54. (in Russian). doi 10.15574/HW.2017.118.50

Frolova N., Tezikov Y., Lipatov I. Obosnovanie vybora angioprotektora diosmina v kachestve profilakticheskogo agenta preeklampsii. [Rationale for the choice of angioprotector diosmin as a preventive agent for preeclampsia]. Izvestija Samarskogo nauchnogo centra Rossijskoj akademii nauk. 2015; 17 (2): 398-403 (in Russian).

Lukyanova Yu.S., Gureev V.V., Kolesnichenko P.D., Danilenko L.M., Gudyrev O.S., Pokrovskaya T.G., Sernov L.N., Artyushkova E.B., Provotorov V.Y. Comparative study of the pharmacological effects of Venarus Plus, Venarus, and Detralex on L-NAME-induced endothelial dysfunction, venous tone and platelet aggregation. AVFT Archivos Venezolanos de Farmacología y Terapéutica. 2020; 39(5): 550-555. https://doi.org/10.5281/zenodo.4266493

Romanenko T.G., Sulimenko O.M. Prevention of preeclampsia in women with multiple pregnancy after assisted reproduction. Wiad Lek. 2020; 73(3): 494-497. PMID: 32285820. DOI: 10.36740/WLek202003116

Downloads

  • PDF

Published

2021-03-31

How to Cite

1.
ZELINKA-KHOBZEY, Marta, TARASENKO, Kostiantyn, MAMONTOVA, Tatyana and SHLYKOVA, Oksana. Prevention of preeclampsia in pregnant women with obesity. Journal of Education, Health and Sport. Online. 31 March 2021. Vol. 11, no. 3, pp. 175-188. [Accessed 23 May 2025]. DOI 10.12775/JEHS.2021.11.03.018.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 11 No. 3 (2021)

Section

Research Articles

License

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 702
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

vascular endothelial growth factor, circulating endothelial microparticles CD32 CD40 , endothelial dysfunction, preeclampsia, pregnancy, obesity
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop