Evaluation of the effectiveness of treatment of experimental postoperative peritonitis
KeywordsPostoperative peritonitis, experiment, sanitation of the abdominal cavity
Purpose: to develop a new method of lavage of the abdominal cavity in the experimental conditions.
Materials and methods. In the experiment we use 40 rats Wistar line weighing 160-240 g, kept in a vivarium in compliance with all standards.
Research results and their discussion. During relaparotomy, we performed mechanical cleaning of the abdominal cavity from fecal masses, layers of fibrin, the abdominal cavity was washed twice with 100 ml of 0.02% decamethoxine solution at a temperature of 30-35 ° C. After removing the drug residues from the abdominal cavity, we pour 50 ml of Extranil peritoneal dialysis solution at a temperature of370C, the active substance of which is icodextrin, not glucose, ie it is not a nutrient medium for microorganisms, but has antimicrobial action due to hyperosmolarity and increases its adsorption properties.
Kovtun AI. Peculiarities of the glutathione system of the liver of rats with acute experimental peritonitis under the action of hyperbaric oxygenation and dalargin / A.I. Kovtun, IF Meshchishen, VM Kopovchuk // Buk.med. herald. - 2005. - V. 9, №2. - P. 126-127.
Sidorchuk RI. Dynamics of changes in the species composition and population level of the microflora of the colon cavity in experimental abdominal sepsis / R.I. Sydorchuk // Ukrainian Medical Almanac. - 2004. - Volume 7, № 4. - P. 53-57
Oberhofer D, Juras J, Pavičić A.-M. Comparison of C-reactive protein and procalcitonin as predictors of postoperative infectious complications after elective colorectal surgery. Croatian Medical Journal. 2012; 53: 612-619.
Launey Y, Duteurtre B, Larmet R, et al. Risk factors for mortality in postoperative peritonitis in critically ill patients. World Journal of Critical Care Medicine. 2017; 6(1): 48-55.
Vlasov AP, Markin OV,Shchapov VV,Salakhov EK,Sheyranov NS,Revva OV, et al. [Homeostasis correcting therapy in optimizing the early postoperative period of patients with peritonitis.] Khirurgiia (Mosk). 2019; (11): 69-75.
Regimbeau JM, Fuks D, Pautrat K, Mauvais F, Haccart V, Msika S, et al. Effect of postoperative antibiotic administration on postoperative infection following cholecystectomy for acute calculous cholecystitis: a randomized clinical trial. JAMA. 2014; 312: 145–54.
Florence C Riche, X. Dray, M.-J. Laisne et al. Factors associated with septic shock and mortality in generalized peritonitis: comparison between community-acquired and postoperative peritonitis. Critical Care. 2009; 13(3): R99.
Augustin P, Kermarrec N, Muller-Serieys C, et al. Risk factors for multidrug resistant bacteria and optimization of empirical antibiotic therapy in postoperative peritonitis. Critical Care. 2010; 14: R20.
Montravers P, Guglielminotti J, Zapella N, et al. Clinical Features and Outcome of Postoperative Peritonitis Following Bariatric Surgery. Obesity Surgery. 2013; 23: 1536-1544.
Bader F, Schroder M, Kujath P, et al. Diffuse Postoperative Peritonitis – Value of Diagnostic Parameters and Impact of Early Indication for Relaparotomy. European Journal of Medical Research. 2009; 14: 491-496.
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