Peculiarities of the condition of vascular platelic hemostasis in diabetic retinopathy and diabetic nephropathy in rats
Keywordsdiabetes mellitus, microangiopathy, vascular-platelet hemostasis, platelet aggregation
The article presents experimental data on the study of changes in vascular platelet hemostasis in rats with experimental DR and DN on the background of type 2 diabetes. It is established that microcirculatory complications of type 2 diabetes are characterized by a decrease in platelet count, increased aggregation capacity. In the study of induced platelet aggregation, the polarity of the results of the study was proved, which indicates the dependence of complications on the functional state of vascular platelet hemostasis, primarily due to stimulated, depleted platelets and the corresponding number of intact platelets. More pronounced changes in vascular-platelet hemostasis on the background of type 2 diabetes in rats with DN compared with the group of animals that reproduced DR.
Bayrasheva VK. Modeling of diabetes mellitus and diabetic nephropathy in an experiment. Modern problems of science and education. 2015;4. https://www.science-education.ru/ru/article/view?id=21024
Barkagan ZS, Momot AP. Diagnosis and controlled therapy of hemostasis disorders. M .: Newdiamed. 2008:292.
Diagnosis of metabolic syndrome: a therapeutic guide*. Reproductive endocrinology. 2012;6 (8):53–55.
Preclinical studies of drugs: a methodology, for ed. Corresponding Member NAMS of Ukraine, acad. O.V. Stefanova. К.: Avicenna. 2001:528.
Kochetov AG, Liang OV, Zhirov IV, et al. Methods of statistical processing of medical data: a methodology. M.: RKNPK. 2012:42.
Pavlov SB. Mechanisms of participation of physiological system of a connecting fabric in formation of pathological processes: doctoral research of Doctor of Med. Science: 14.03.04 / Sergey Borisovich Pavlov. Sumy. 2017:394.
Reznikov OG, Solovyov AI, Stefanov OV. Biotic examination of preclinical and other scientific researches performed on animals: method. recommendations. Bulletin of Pharmacology and Pharmacy. 2006;7:47–61.
Severina AS, Shestakova MV. Disorder of the hemostasis system in patients with diabetes mellitus. Diabetes mellitus. 2004;1:62–67.
Sibireva OF, Urazova OI, Kalyuzhin VV. Indicators of platelet hemostasis and endothelial dysfunction in patients with diabetes mellitus with diabetic nephropathy. Ukrainian Journal of Extreme Medicine named after G.O. Mozhaeva. 2012;1 (13):39–43.
Tsitovsky MN. Statistical, clinical and morphological aspects of the influence of diabetes on the state of the cardiovascular system. Scientific Bulletin of Uzhhorod University. 2017;55(1):168–177.
IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045 / NH Cho et al. Diabetes Res Clin Pract. 2018;138:271–281.
Abdeen ZA, et al World Health Organization. Global report on diabetes 2016. 88 pp. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 2016;387(10027):1513–1530.
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