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Journal of Education, Health and Sport

Long-term survival after surgical management of renal cell carcinoma with venous tumor thrombus
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  • Long-term survival after surgical management of renal cell carcinoma with venous tumor thrombus
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Long-term survival after surgical management of renal cell carcinoma with venous tumor thrombus

Authors

  • Yuliya Stepanivna Mota Danylo Halytsky Lviv National Medical University Department of Surgery №2 https://orcid.org/0000-0002-6332-8404

DOI:

https://doi.org/10.12775/JEHS.2020.10.12.024

Keywords

renal cell carcinoma, inferior vena cava thrombus, radical nephrectomy, thrombectomy, long-term outcomes

Abstract

The aim: to evaluate the long-term survival in patients after surgical management of renal cell carcinoma with venous tumor thrombus.

Materials and methods. From 1993 to 2019 88 patients with renal cell carcinoma, complicated by venous tumor thrombus, were observed at the Vascular surgery department of  Lviv Regional Clinical Hospital: 65 (73.9%) men, 23 (26.1%) women, mean age – 58.7 ± 1.9 years. Surgical management  included radical nephrectomy in combination with thrombectomy from inferior vena cava and right atrium.  Kaplan-Meier method  and log-rank test were used for survival analysis.

Results and discussion. Long-term survival was evaluated in 78 patients, the median follow-up was 51.6±14.3 months. Cumulative 2-, 5- and 10-year survival rates of patients with renal vein tumor thrombus (78.8%, 48.1%, 37.4%) were significantly higher compared to patients with intraatrial and inferior vena cava tumor thrombus (53.5%, 38.2%, 17.2%) (p<0.05). There was no significant difference in survival among patients with renal cell carcinoma, complicated with tumor venous thrombus, without and with metastases (p>0.05). Regarding to  inferior vena cava tumor thrombus level there also was no significant difference in survival (p>0.05). As for the prognostic value of tumor histological gradation, the overall survival parameters were significantly higher in patients with G1-G2 compared with G3-G4 differentiation degrees of renal cell carcinoma (p<0.05).

Conclusions. Radical nephrectomy with thrombectomy from inferior vena cava and right atrium remains the only curative treatment for patients with  renal cell carcinoma and venous tumor thrombus that allows to provide reasonable long-term survival outcomes.

Author Biography

Yuliya Stepanivna Mota, Danylo Halytsky Lviv National Medical University Department of Surgery №2

Department of Surgery №2 PhD student

References

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Published

2020-12-28

How to Cite

1.
MOTA, Yuliya Stepanivna. Long-term survival after surgical management of renal cell carcinoma with venous tumor thrombus. Journal of Education, Health and Sport [online]. 28 December 2020, T. 10, nr 12, s. 246–255. [accessed 23.3.2023]. DOI 10.12775/JEHS.2020.10.12.024.
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Vol. 10 No. 12 (2020)

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Research Articles

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