The role of lipid peroxidation and antioxidant protection in skin in the development of experimental contact dermatitis
Keywordscontact dermatitis, malonic dialdehyde, diene conjugate, superoxidedismutase, catalase, glutationperoxidase, glutationreductase
AbstractThe purpose of work to study the conditions of prooxidant andantioxidant system in the skin of guinea pigs in different periods of contact dermatitis formation.
Materials and methods. Researches were conducted on guinea pigs, divided into five groups: I - control, II – 4th day of expirement, III – 8th day of contact dermatitis development, IV – 10th day and V - 18 th day of model process. Early period included groups of animals on the 4th and 8th days of experiment. The late one – guinea pigs on the 10th and 18th days of contact dermatitis. Experimental contact dermatitis was simulated by method of
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