Value of conditionally-pathogenic microflora index as predicting factor of bacterial dysbiosis’ development
DOI:
https://doi.org/10.12775/JEHS.2020.10.11.032Keywords
dysbiosis, conditionally pathogenic microflora, diagnostics, colonial resistanceAbstract
An article shows the most informative indicators that objectively reflect the condition of the pathological process of dysbiosis, and a system for predicting of the risk of occurrence and severity of dysbiosis according to these indicators is developed. Results of the study substantiated the assumptions about the pathogenetic role of disregulation of hormonal and immune systems in the occurrence of dysbiosis and bacterial vaginosis. Synshronously, the stage of the development of the immune system reaction is discovered in the during the flow of vaginal dysbiosis - from the control stay while normocoenosis to the immunoresistance in grade 1 dysbiosis and expressed combined immunodeficiency in the presence of specific humoral response to bacterial antigens in 2nd grade dysbiosis.
References
Anahtar MN, Byrne EH, Doherty KE, Bowman BA, Yamamoto HS, Soumillon M, Padavattan N, Ismail N et al. Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract. Immunity. 2015 May 19;42(5):965-76. doi: 10.1016/j.immuni.2015.04.019.
Bertran T, Brachet P, Vareille-Delarbre M, Falenta J, Dosgilbert A, Vasson MP, Forestier C, Tridon A, Evrard B. Slight Pro-Inflammatory Immunomodulation Properties of Dendritic Cells by Gardnerellavaginalis: The "Invisible Man" of Bacterial Vaginosis? J Immunol Res. 2016; 2016:9747480. doi: 10.1155/2016/9747480.
Coudray MS, Madhivanan P. Bacterial vaginosis – A brief synopsis of the literature. Eur J ObstetGynecolReprod Biol. 2020 Feb;245:143-148. doi: 10.1016/j.ejogrb.2019.12.035.
Cox C, Watt AP, Mc Kenna JP, Coyle PV. Mycoplasma hominis and Gardnerellavaginalis display a significant synergistic relationship in bacterial vaginosis. Eur J Clin Microbiol Infect Dis. 2016 март; 35 (3): 481-7. doi: 10.1007 / s10096-015-2564-x.
Delves PJ, Martin SJ, Burton DR, Roitt IM. Roitt's Essential Immunology, 13th Edition. 2016. Wiley-Blackwell, 576 p.
Gruzevskyy OA. [Colonization resistance in vaginal dysbiosis: the state of humoral and cellular links]. Bul marine med. 2017; 4(77):103-7. [in Russian]
Gruzevskiy OA, Vladymirova MP. [Results of a complex bacteriological study of vaginal contents under the conditions of bacterial vaginosis]. Ach biol and med. 2014;2:54-7. [in Ukrainian]
Guryanov VG, Liakh YuE, Paryy VD, Short OJ, Chaly OJ, Chaly KO, et al. [Biostatistics Guide. Analysis of medical research results in the EZR (R-statistics) package]. Kiev.: Vistka, 2018. 208 p. [in Ukrainian]
Hilbert DW, Smith WL, Paulish-Miller TE2, Chadwick SG, Toner G, Mordechai E, Adelson ME, Sobel JD, Gygax SE. Utilization of molecular methods to identify prognostic markers for recurrent bacterial vaginosis. Diagn Microbiol Infect Dis. 2016 Oct;86(2):231-42. doi: 10.1016/j.diagmicrobio.2016.07.003.
Hruzevskyi O.A. A status of cellular immunity in bacterial dysbiosis and bacterial vaginosis. Austrian Journal of Biomedical and Life Sciences. – 2020. - №5-6. – p.14-21, 68 P. DOI: 10.29013/AJT-20-5.6-14-21
Hruzevskyi O.A. Bacterial dysbiosis risk prediction according to vaginal normobiota indicator.The European Science Review. – 2020. - №5-6. – p.13-21. DOI: 10.29013/ESR-20-5-6-13-21
Hruzevskyi O.A. Influence of local factors of colonization resistance on vaginal microbial biocenosis. European Journal of Technical and Natural Sciences. – 2020. - №3. – p. 7-15, 42 P. DOI: 10.29013/EJTNS-20-3-7-15
Kremleva EA, Sgibnev AV. Proinflammatory cytokines as regulators of vaginal microbiota. Bull ExpBiol Med. 2016 Nov;162(1):75-78. doi: 10.1007/s10517-016-3549-1.
Larsen JM. Theimmune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017 Aug;151(4):363-374. doi: 10.1111/imm.12760.
Lipova EV, Boldyreva MN, Trofimov DYu, Vitvitskaya YuG. [Femoflor. Urogenital infections caused byconditionally biota in women of reproductive age (clinical and laboratory diagnostics). Manualfordoctors]. Moscow: DNA technology. 2015. 30 p. [in Russian]
Masson L, Barnabas S, Deese J, Lennard K, Dabee S, Gamieldien H, Jaumdally SZ, Williamson AL et al. Inflammatory cytokine biomarkers of asymptomatic sexually transmitted infections and vaginal dysbiosis: a multicentre validation study. Sex Transm Infect. 2019 Feb;95(1):5-12. doi: 10.1136/sextrans-2017-053506.
Muzny CA, Taylor CM, Swords WE, Tamhane A, Chattopadhyay D, Cerca N, Schwebke JR. An updated conceptual model on the pathogenesis of bacterial vaginosis. J Infect Dis. 2019 Sep 26;220(9):1399-1405. doi: 10.1093/infdis/jiz342.
Muzny CA, Schwebke JR. pathogenesis of bacterial vaginosis: discussion of current hypotheses. J Infect Dis. 2016 Aug 15;214Suppl 1:S1-5. doi: 10.1093/infdis/jiw121.
Nasioudis D, Linhares IM, Ledger WJ, Witkin SS. Bacterial vaginosis: a critical analysis of current knowledge. BJOG. 2017 Jan;124(1):61-69. doi: 10.1111/1471-0528.14209.
Onderdonk AB, Delaney ML, Fichorova RN. The Human Microbiome during bacterial vaginosis. ClinMicrobiol Rev. 2016 Apr;29(2):223-38. doi: 10.1128/CMR.00075-15.
van Teijlingen NH, Helgers LC, Zijlstra-Willems EM, van Hamme JL, Ribeiro CMS, Strijbis K, Geijtenbeek TBH. Vaginal dysbiosis associated-bacteria Megasphaeraelsdenii and Prevotellatimonensis induce immune activation via dendritic cells. J ReprodImmunol. 2020 Apr;138:103085. doi: 10.1016/j.jri.2020.103085.
Downloads
Published
How to Cite
Issue
Section
License
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 528
Number of citations: 0