The influence of Helicobacter pylori on the level of endotheline-1 and nitrogen oxide in the blood of children with the duodenal ulcer
DOI:
https://doi.org/10.12775/JEHS.2020.10.11.026Keywords
Children, H. pylori, Duodenal ulcer, Endothelin-1, Nitrogen oxideAbstract
The most serious pathology of the of gastrointestinal tract in children remains duodenal ulcer (DU). Interesting is the study of the role of endothelin-1 and nitrogen oxide in the formation of DU.
The aim. To evaluate the nature of changes in the level of nitrogen oxide (NO) and endothelin-1 (Et-1) in the blood of children with H pylori-associated DU.
Methods. A single-center study was conducted in 42 children with DU aged 6–18 years and 20 children comparison group. Diagnostics of H. pylori was performed primary endoscopy and 4 weeks after the end of treatment. Blood samples were collected in each visit to measure plasma Et-1 using an enzyme immunoassay kit and NO (nitrate/nitrite) levels Golikov's method.
Results. In 37 (92.5%) the ulcers went through re-epithelialization, while successful eradication of H. pylori was achieved in 32 people (80%). The NO level in the blood plasma of the children of the main group was 9.78 ± 1.13 mmol/l, after treatment –11.09 ± 1.2 mmol/l. After eradication of H. pylori, the level of Et-1 decreased from 2.39 ± 0.08 to 1.14 ± 0.07 pg / ml.
Conclusion. Levels of endothelin-1 (Et-1) and nitrogen oxide (NO) in children with duodenal ulcer vary depending on the stage of the disease. After H-pylori eradication, ulcer defect healing is associated with decreased of Et-1 inplasma and increased NO activity.
References
Guariso G, Gasparetto M. Update on Peptic Ulcers in the Pediatric Age. Hindawi Publishing Corporation. Ulcers. 2012; Article ID 896509, 9 p.
Kalach N, Bontems P, Cadranelb S. Advances in the treatment of Helicobacter pylori infection in children. Ann Gastroenterol. 2015; 28(1): 10–18. doi: 10.3748/wjg.v9.i12.2701.
Diaconu S, Predescu A, Moldoveanu A, Pop CS, Fierbințeanu-Braticevici C. Helicobacter pylori infection: old and new. J Med Life. 2017;10(2): 112–117. PMCID: PMC5467250.
Kori M, Daugule I, Urbonas V. Helicobacter pylori and some aspects of gut microbiota in children. Helicobacter.2018; 23, Suppl 1:e12524. DOI:10.1111/hel.12524.
Chang WL, Yeh YC, Sheu BS. The impacts of H. pylori virulence factors on the development of gastroduodenal diseases. J Biomed Sci. 2018;25:68. doi: 10.1186/s12929-018-0466-9.
Koletzko S, Jones NL, Goodman K. et al. On behalf of the H.pylori working groups of ESPGHAN and NASPGHAN. Evidence-based guidelines from ESPGHAN and NASPGHAN for Helicobacter pylori infection in children. J Pediatr Gastroenterol Nutr. 2011;53:230–243. doi: 10.1097/MPG.0000000000001594.
Eusebi LH, Zagari RM, Bazzoli F. Epidemiology of Helicobacter Pylori Infection. Helicobacter. 2014; 19(1):1-5. doi: 10.1111/hel.12165.
Kotilea K, Mekhael J, Salame A et al. Eradication rate of Helicobacter Pylori Infection Is Directly Influenced by Adherence to Therapy in Children. Helicobacter. 2017;22 (4): 7-14. https://doi.org/10.1111/hel.12383.
Jarc E, Poljak M, Homan M. Helicobacter pylori virulence genes. World J Gastroenterol. 2019; 25(33): 4870–4884. doi: 10.3748/wjg.v25.i33.4870.
CDC 2007. Available from: http: //wwwnc.cdc.gov/travel/yellowbook/ 2014/chapter-3-infectious-diseases-related-to-travel/helicobacter-pylori.
Ertem D. Clinical practice: Helicobacter pylori infection in childhood. Eur J Pediatr. 2013;172:1427–1434. doi: 10.1007/s00431-012-1823-4.
Malfertheiner P, Megraud F, O'Morain CA et al. Management of Helicobacter pylori infection-the Maastricht V/Florence. Consensus Report. Gut. 2017;66:6–30. http://dx.doi.org/10.1136/gutjnl-2016-312288.
Tominaga K, Higuchi K, Iketani T. et al. Comparison of gastrointestinal symptoms and psychological factors of functional dyspepsia to peptic ulcer or panic disorders patients. Inflammopharmacology. 2007;15:84–89. https://doi.org/10.1007/s10787-006-0011-4
Tominaga K, Fujikawa Y, Tsumoto Ch et al. Disorder of autonomic nervous system and its vulnerability to external stimulation in functional dyspepsia. J Clin Biochem Nutr. 2016 Mar; 58(2): 161–165. doi: 10.3164/jcbn.15-140.
Shah V, Lyford G, Gores G, Farrugia G. Nitric oxide in gastrointestinal health and disease. Gastroenterology. 2004;126:903-913. doi: 10.1053/j.gastro.2003.11.046.
Tejero J, Shiva S, Gladwin MT. Sources of vascular nitric oxide and reactive oxygen species and their regulation. Physiol rev. 2019; 99(1):311–379. doi: 10.1152/physrev.00036.2017.
Lanas A. Role of nitric oxide in the gastrointestinal tract. Arthritis Res Ther. 2008; 10(2): 4. doi: 10.1186/ar2465.
Yanagisawa M. The endothelin system. A new target for therapeutic intervention. Circulation. 1994;89:1320-1322.
Wang L, Zhou Y, Peng J. et al. Role of endogenous nitric oxide synthase inhibitor in gastric mucosal injury. Can J Physiol Pharmacol. 2008;86(3):97-104. doi: 10.1139/y08-003.
Zhang Z, Zou YY, Li FJ, Hu CP. Asymmetric dimethylarginine: a novel biomarker of gastric mucosal injury? World J Gastroenterol. 2011;17(17):2178-80. doi: 10.3748/wjg.v17.i17.2178.
Munzel T, Sinning C, Post F. et al. Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction. Ann Med. 2008; 40 (3):180-196. doi: 10.1080/07853890701854702.
Coskun S, Kasirga E, Yilmaz O. et al. Is Helicobacter pylori related to endothelial dysfunction during childhood? Pediatr Int. 2008 Apr;50(2):150-3. doi: 10.1111/j.1442-200X.2008.02542.x. .
Ohara H, Isomoto H, Wen CY et al. Expression of mucosal addressin cell adhesion molecule 1 on vascular endothelium of gastric mucosa in patients with nodular gastritis. World J Gastroenterol. 2003;9(12):2701-5. doi: 10.3748/wjg.v9.i12.2701.
Shu X, Stevenson TC, Keller I et al. Endothelial nitric oxide synthase in the microcirculation. Cell Mol Life Sci. 2015; 72(23): 4561–4575. DOI: 10.1007/s00018-015-2021-0
Hajiaghamohammadi AA, Zargar A, Oveisi S et al. To Evaluate of the Effect of Adding Licorice to the Standard Treatment Regimen of Helicobacter Pylori. Braz Infect Dis. 2016;20 (6):534-538. doi: 10.1016/j.bjid.2016.07.015.
Roberts SE, Morrison-Rees S, Samuel DG et al. Review article: the prevalence of Helicobacter pylori and the incidence of gastric cancer across Europe. Aliment. Pharmacol. Ther. 2016; 43, 334–345. doi: 10.1111/apt.13474.
Marushko Y. Current data on the duration of therapy antisecretory drugs acid diseases in children (review of literature). Modern pediatrics. 2013;1(49)-118-122 [In Ukrainian].
Nazlı Arslan, Özlem Yılmaz, Ebru Demiray-Gürbüz. Importance of antimicrobial susceptibility testing for the management of eradication in Helicobacter pylori infection. World J Gastroenterol. 2017;28(16): 2854–2869. doi: 10.3748/wjg.v23.i16.2854.
Smith SM. An update on the treatment of Helicobacter pylori infection. EMJ Gastroenterol. 2015;4:101–107.
O’Connor A, Gisbert JP, O’Morain C, Ladas S. Treatment of Helicobacter pylori Infection 2015. Helicobacter. 2015;20(1):54–61. doi: 10.1111/hel.12258.
Haghazali M, Molaei M, Mashayekhi R et al. Proinflammatory cytokines and thrombomodulin in patients with peptic ulcer disease and gastric cancer, infected with Helicobacter pylori. Indian Journal of Pathology and Microbiology. 2018; 54(1):103-6. https://www.ijpmonline.org/text.asp?2011/54/1/103/77343
Endemann DH, Schiffrin EL. Endothelial dysfunction. J Am Soc Nephrol. 2004;15:1983–1992. doi: 10.1097/01.ASN.0000132474.50966.DA.
Chang FY, Chen ChY, Lu ChL et al. Response of blood endothelin-1 and nitric oxide activity in duodenal ulcer patients undergoing Helicobacter pylori eradication. World J Gastroenterol. 2005;21;11(7):1048–1051. doi: 10.3748/wjg.v11.i7.1048.
Masuda E, Kawano S, Michida T et al. Plasma and gastric mucosal endothelin-1 concentrations in patients with peptic ulcer. Dig Dis Sci. 1997; 42: 314–318. https://doi.org/10.1023/A:1018809801185.
Akimoto M, Hashimoto H, Maeda A, Shigemoto M, Yamashita K. Roles of angiogenic factors and endothelin-1 in gastric ulcer healing. Clin Sci (Lond). 2002; 103(48): 450–454. doi: 10.1042/CS103S450S.
Som S, Banik GD, Maity A et al. Exhaled nitric oxide as a potential marker for detecting non-ulcer dyspepsia and peptic ulcer disease. Journal of Breath Research. 2018;12(2):143-147. doi: 10.1088/1752-7163/aa8efb.
Magierowski M, Magierowska K, Kwiecien S, Brzozowski T. Gaseous Mediators Nitric Oxide and Hydrogen Sulfide in the Mechanism of Gastrointestinal Integrity, Protection and Ulcer Healing. Molecules. 2015; 20(5): 9099–9123. doi: 10.3390/molecules20059099.
Han T, Tang Y, Li J et al. Nitric oxide donor protects against acetic acid-induced gastric ulcer in rats via S-nitrosylation of TRPV1 on vagus nerve. Sci Rep 2017; 7:2063. https://doi.org/10.1038/s41598-017-02275-1.
Chakraborty Sh, Ain R. Nitric-oxide synthase trafficking inducer is a pleiotropic regulator of endothelial cell function and signaling. J Biol Chem. 2017 Apr 21; 292(16): 6600–6620. doi: 10.1074/jbc.M116.742627.
Chmiela M, Kupcinskas J. Review: Pathogenesis of Helicobacter pylori infection Helicobacter. 2019; 24(1): e12638. doi: 10.1111/hel.12638.
Downloads
Published
How to Cite
Issue
Section
License
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 1010
Number of citations: 0
