Influence of thyroid hormones and drag for anesthesia on homeostasis of the humoral pert of the immune system and Red-OX system in the rat’s body
DOI:
https://doi.org/10.12775/JEHS.2020.10.11.020Keywords
free radicals, humoral immunity, hyperthyroidism, sodium thiopental, dexmedetomidineAbstract
Introduction. The increase in the prevalence of hyperthyroidism justifies the feasibility of experimental studies to study the mechanisms of thyroid hormones on a number of metabolic processes and homeostasis in euthyroidism and hyperthyroidism in the experiment and increases against the background of preoperative stress.
The aim of the study: to find out the peculiarities of the reaction of the immune system and free radical processes of experimental animals under conditions of simulated hyperthyroidism to the action of various drugs for anesthesia.
Research methods. To simulate the state of hyperthyroidism, rats received L-thyroxine for 21 days. The effect of euthyroidism and hyperthyroidism on the level of homeostasis of the humoral part of the immune system and free radicals on the introduction of sodium thiopental and dexmedetomidine in the experiment compared.
Results and discussion. In the blood plasma of animals with experimental hyperthyroidism, changes in the level of the humoral part of the immune system and free radicals were observed under the influence of sodium thiopental and dexmedetomidine hydrochloride under conditions of hyper- and euthyroidism.
Conclusions. Activation of metabolic processes of the thyroid gland affects the universal defense systems of the body, which is especially evident in conditions of operational and perioperative stress by disruption of homeostasis of the immune system and the activity of free radicals.
References
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2016;26(1):1-133. doi:10.1089/thy.2015.0020
Nechyporuk VM,. Zaichko NV, Korda MM. [Effect of thyroid hormones on the sulfur-containing amino acids remethylation and transsulfuration pathways in rats organs]. Medychna ta klinichna khimiya. 2017;19(1):12–16. (in Ukrainian).
Orzechowska-Pawilojc A, Siekierska-Hellmann M, Syrenicz A, Sworczak K. Homocysteine, folate, and cobalamin levels in hyperthyroid women before and after treatment. Endokrynol. Pol. 2009; 60 (6):443-448.
Somova OV. Interrelation of organism`s thyroid state and processes of lipid peroxidation: thesis for a candidate`s degree by speciality 03.00.13: Physiology of human and animals. Kharkiv, 1999. (in Ukrainian).
Oleynik VA, Markov VV, Gulevatyy SV, Matyashchuk SI, Sovenko TK. [Clinical Protocol of Post-Surgical Management of Patients with Differentiated Thyroid Cancer]. Liky Ukrayiny. 2010;146(10):73–75. (in Ukrainian).
Dubinina YeYe, Burmistrov SO, Khodov DA, Porotov IG. [Oxidative modification of human blood serum proteins method of its determination] Vopr. med. khim. 1995;41(1):24–26.
Kozhemyakin YuM, Khromov OS, Filonenko MA, Sayfetdinova HA. Scientific and practical recommendations for keeping laboratory animals and working with them. Kyiv: Avicenna; 2002. 156 р. (in Ukrainian).
Stepanyuk HI, Shevchuk OK. Vinnytskyy natsionalnyy medychnyy universytet imeni M. I. Pyrohova [Method of anesthesia in rats during gastric surgery]. UA 3386. 2004, published. 15.11.2004. Bul.11. (in Ukrainian).
Kharkevich D.A. Pharmacology: a textbook for students of medical universities. Moscow: Medicine;1981. 133 p. (in Russian).
Pavlov AA, Podrez YeV. [Place of α2-agonists in combined anesthesia. Meditsina neotlozhnikh sostoyaniy]. 2014;8(63):9–12. (in Ukrainian).
Gavrilov VB, Mishkorudnaya MI. [Spectrophotometric determination of the content of lipid hydroperoxides in blood plasma]. Laboratory work. 1983;3:33–36. (in Russian).
Rom-Buguslavskaya ES, Somova EV, Grinchenko TS. [Lipid peroxidation in patients with diffuse toxic goiter and hypothyroidism]. Мedical business. 1998;1:88–91. (in Russian).
Stalnaya ID, Garishvili TG. Method for the determination of malonic dialdehyde using thiobarbituric acid. In: Orekhovich VN, ed. Modern methods in biochemistry. Moscow: Medicine; 1977:p. 66–68. (in Russian).
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