Marker profile of digestive system organs comorbid pathology in children
DOI:
https://doi.org/10.12775/JEHS.2020.10.10.026Keywords
comorbid pathology, digestive system organs, children, risk factorsAbstract
The article highlights the current state of the comorbid pathology of the digestive system problem in children. Attention is paid to the most significant trigger factors of comorbid pathology of the digestive system organs in children and they are given a prognostic assessment with the development of a mathematical model of developmental risk.
Aim. To identify predictors of comorbid pathology of the digestive system in children and to determine their prognostic value.
Material and methods. 115 children with comorbid pathology of the digestive system organs and 80 healthy children aged 7-18 years were examined. The state of biological, social and genealogical well-being was determined by means of questionnaires. Laboratory and instrumental studies were conducted in accordance to the Ministry of Health ofUkraineorders in the specialty "Pediatric Gastroenterology" with the informed consent of patients to participate in the study.
Results. Etiologically determining risk factors for the development of comorbid pathology of the digestive system organs in children are unfavorable genealogical history with hereditary burden by both pedigrees, age and sex of the child, H. pylori infection, stress, vitamin D3 and iodine deficiency, endothelial dysfunction, disruptions of regional blood flow in the abdominal trunk, premorbid background.
Conclusion. It is established that the risk of comorbid pathology of the digestive system in children will increase by 4.27 times if the child has identified by us non-modifying factors, and by 2.62 times under the influence of modifying factors.
References
Attaallah W, Yener N, Ugurlu MU, Manukyan M, Asmaz E, Aktan AO. Gallstones and Concomitant Gastric Helicobacter pylori Infection. Gastroenterol Res Pract. 2013; 643109. doi: 10.1155 / 2013/643109.
Figure N, Di Cairano G, Moretti E et al. Helicobacter pylori Infection and Autoimmune Thyroid Diseases: The Role of Virulent Strains. Antibiotics (Basel). 2019; 9 (1): 12. Published 2019 Dec 30. doi: 10.3390 / antibiotics9010012.
Fletcher R. Fletcher S., Wagner E. Clinical epidemiology. Fundamentals of evidence-based medicine / trans. with English S.E. Bashchinskogo, M .: Media Sfera, 2004;352.
Marushko RV Risk factors and prediction of the development of functional and chronic inflammatory bowel diseases in young children. Perinatology and pediatrics. 2014;1(57):51-55.
Palanduz A., Erdem L., Cetin BD., Ozcan NG. Helicobacter pylori infection in family members of patients with gastroduodenal symptoms. A cross-sectional analytical study. Sao Paulo Med. J. 2018;136(3):222-227.
Shekera OG, Melnyk DV. Prevalence of digestive diseases and duodenal ulcers among children - current problems of family medicine. Family medicine. 2017;69(1):16-20.
Skubytska LD, Severinovska OV. Complex analysis of blood parameters and acid-forming function of the stomach in diseases of the hepatobiliary system with concomitant pathologies. Bulletin of VNKarazin Kharkiv National University. 2016;27:139-149.
Sorokman TV, Popelyuk OM, Lozyuk IY Peculiarities of the course of combined pathology of the upper gastrointestinal tract and allergodermatoses in children. Child health. 2017;12(3):324-328.
Sorokman TV, Sokolnyk SV, Lozyuk IYa, Sokolnyk SO, Moldovan PM, Kopchuk TH, Yakovets KI. Ultrasonographic indices of skin changes in children with Helicobacter pylori-associated gastroduodenitis combined with food allergy. Archives of Balkan Medical Union. 2018;53(3):355-363.
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