Characteristics of Anxiety Manifestations and Hormonal Profile of Women with Threatened Interruption of Pregnancy, Living in Lugansk Region
DOI:
https://doi.org/10.12775/JEHS.2020.10.10.022Keywords
pregnancy, threatened interruption of pregnancy, progesterone, prolactin, cortisol, anxietyAbstract
The threatened interruption of pregnancy (TIP) is the most common pregnancy complication that occurs in 15-20% of cases of ongoing pregnancy. The aim of the study was to identify the prevalence and severity of anxiety, the hormonal profile of in pregnant women with threatened interruption of pregnancy in the I and II trimesters, living in the Lugansk region in the area of armed conflict in Eastern Ukraine, to improve treatment and prophylactic measures and prevent obstetric and perinatal complications in such women. Material and methods. The study included 67 pregnant women who were hospitalized regarding TIP to the hospitals, located in the Lugansk region (group I). The control group consisted of 30 pregnant women with non-complicated obstetric anamnesis and physiological course of pregnancy with similar gestational period of pregnancy and place of residence (group II). Spielberger State-Trait Anxiety Inventory was used to assess the level of anxiety, quantitative assessment of concentration of estradiol, progesterone, prolactin, cortisol in blood plasma was determined. Results and discussion. Prevalence of anxiety disorders among pregnant women with TIP living in the armed conflict area was in 2.4 times more often than healthy pregnant women and made up 68,60%. They have significantly higher levels of state and trait anxiety; a positive correlation between the level of state anxiety and concentrations of cortisol, prolactin were found. Conclusions. Antenatal study of levels of anxiety, hormonal homeostasis in pregnant women with TIP living in the armed conflict area allowed to individualize the approach to the management of pregnancy and if needed to timely develop rehabilitating activities, that will contribute to a successful outcome of the pregnancy and affect the health of the mother and her offspring.
References
Keren M., Keren N., Eden A. et al. The complex impact of five years of stress related to life-threatening events on pregnancy outcomes: a preliminary retrospective study. Eur Psychiatry. 2015 Feb;30(2):317-21. doi: 10.1016/j.eurpsy.2014.10.004.
Biaggi A., Conroy S., Pawlby S. et al. Identifying the women at risk of antenatal anxiety and depression: A systematic review. J Affect Disord. 2016 Feb;191:62-77. doi: 10.1016/j.jad.2015.11.014.
Makhashvili N., Chikovani I., McKee M. et al. Mental disorders and their association with disability among internally displaced persons and returnees in Georgia. J Trauma Stress, 2014 Oct;27(5):509-18. doi: 10.1002/jts.21949.
King NM, Chambers J, O'Donnell K et al. Anxiety, depression and saliva cortisol in women with a medical disorder during pregnancy. Arch Womens Ment Health. 2010 Aug;13(4):339-45. doi: 10.1007/s00737-009-0139-5.
Kicia M., Skurzak A., Wiktor K. et al. Anxiety and stress in miscarriage. Pol J Public Health. 2015;125(3): 162-165. doi: https://doi.org/10.1515/pjph-2015-0046.
Niloufer S. Ali, Iqbal S. Azam, Badar S. Ali et al. Frequency and Associated Factors for Anxiety and Depression in Pregnant Women: A Hospital-Based Cross-Sectional Study. Scientific World Journal. 2012; 2012: 653098. doi: 10.1100/2012/653098.
Rallis S., Skouteris H., McCabe M. et al. A prospective examination of depression, anxiety and stress throughout pregnancy. Women Birth, 2014 Dec;27(4):e36-42. doi: 10.1016/j.wombi.2014.08.002.
Lee A.M., Lam S.K., Sze Mun Lau S.M. et al. Prevalence, course, and risk factors for antenatal anxiety and depression. Obstet Gynecol, 2007 Nov;110(5):1102-12. doi: 10,1097 / 01.AOG.0000287065.59491.70.
Ahmed S.R., El-Sammani Mel-K., Al-Sheeha M.A. et al. Pregnancy outcome in women with threatened miscarriage: a year study. Mater Sociomed. 2012;24(1):26-8. doi: 10.5455/msm.2012.24.26-28.
Evrenos A.N., Cakir Gungor A.N., Gulerman C. et al. Obstetric outcomes of patients with abortus imminens in the first trimester. Arch Gynecol Obstet. 2014;289:499–504. doi: 10,1007 / s00404-013-2979-5
Shah D., Nagarajan N.. Luteal insufficiency in first trimester. Indian J Endocrinol Metab. 2013;17:44–49. doi: 10.4103/2230-8210.107834.
Parker V.J., Douglas A.J. Stress in early pregnancy: maternal neuro-endocrine-immune responses and effects. J Reprod Immunol. 2010;85:86–92. doi: 10.1016 / j.jri.2009.10.011.
Weiss J.L., Malone F.D., Vidaver J. et al. Threatened abortion: A risk factor for poor pregnancy outcome, a population-based screening study. Am J Obstet Gynecol. 2004;190:745–50. doi: 10.1016 / j.ajog.2003.09.023
Dadkhah F., Kashanian M., Eliasi G. A comparison between the pregnancy outcome in women both with or without threatened abortion. Early Hum Dev. 2010;86:193–96. doi: 10.1016 / j.earlhumdev.2010.02.005.
Hanin Yu.L. Issledovanie trevogi v sporte. [Study of anxiety in sports]. Vopr. Psihologii. 1975;6:72-75
Faisal-Cury A., Rossi Menezes P. Prevalence of anxiety and depression during pregnancy in a private setting sample. Archives of Women’s Mental Health. 2007;10(1):25–32. doi: 10,1007 / s00737-006-0164-6.
Ku C., Allen Jr. JC., Lek S. et al. Serum progesterone distribution in normal pregnancies compared to pregnancies complicated by threatened miscarriage from 5 to 13 weeks gestation: a prospective cohort study. BMC Pregnancy Childbirth. 2018;18,360. doi: 10,1186 / s12884-018-2002-z.
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