Comparative nephrotoxic effect on rats of different pathogens
DOI:
https://doi.org/10.12775/JEHS.2020.10.10.019Keywords
kidneys, toxins, lipopolysaccharide, markers of inflammationAbstract
Aim. Compare the nephrotoxicity of different pathogens.
Methods. Nephrotoxicity was assessed in rats treated with the following pathogens: hydrazine sulfate, prednisolone, cyclophosphamide, lincomycin and lipopolysaccharide, according to the degree of increase in biochemical markers of inflammation: elastase activity and malondialdehyde (MDA) content.
Result. A significant increase in the level of both inflammatory markers in the kidneys was established, the most pronounced under the influence of hydrazine sulfate. The recalculation of the percentage increase in the level of markers per 1 mg of the pathogen (specific pro-inflammatory activity, SPIA) showed the highest SPIA in lipopolysaccharide, especially after oral applications, exceeding SPIA for hydrazine sulfate by a factor of thousands.
Conclusion. The pro-inflammatory effect on kidneys of many non-microbial toxicants can be realized through the formation of lipopolysaccharide by lysis of gram-negative bacteria.
References
Smirnov AV, Dobronravov VA, Bodur-Oorzhak ASh [and others]. Epidemiology and risk factors for chronic kidney disease: regional level of the General problem. Therapeutic archive.. 2005; 77(6): 20-27. (in Russian)
Stepan VT. The development of inflammation and dysbiosis in kidneys and bladder wall in rats at stomatogenic endotoxemia. Dentistry Bulletin. 2016; 2(95): 6-9. (in Russian)
Sanyaolu A, Okorie C, Annan R [and others]. Epidemiology and management of chronic renal failure: a global public health problem. Biostatistics Epidemiolmoil J. 2018; 1(1): 11-16.
Levitsky AP, Gozhenko AI, Stepan VT [and others]. Biochemical markers of inflammatory-dystrophic and dysbiotic processes in the kidneys in experimental pathology: guidelines.Odessa, 2020: 20. (in Ukrainian)
Levitsky AP, Selivanskaya IA, Tsiselskiy YuV [and others]. The method of simulation of dysbiosis (dysbacteriosis). Patent of Ukraine 31012. IPC (2006) А61Р 31/00. Application number u 200711609. Date of filling: 22.10.2007. Publ.: 25.03.2008. Bul. № 6. (in Ukrainian)
Levitsky AP. Stomatogenic endotoxinemia. Journal of the National Academy of Medical Sciences of Ukraine. 2013; 19(4): 490-493. (in Russian)
Truhacheva NV. Mathematical Statistics in biomedical research using application package Statistica. Moskow, GJeOTAR-Media, 2012: 379. (in Russian)
Levitsky AP, Gozhenko AI, Stepan VT [and others]. Dysbiotic aspects of pathogenesis and antidysbiotic prophylactics of experimental nephropathy. Journal of Education, Health and Sport. 2017; 7(6): 1124-1136. (in Russian)
Levitsky AP. Disbiotic syndrome: etiology, pathogenesis, clinic, prevention and treatment. Dentistry Bulletin. 2019; 10(special issue): 14-20. (in Russian)
Bocharov AV, Makarenko OA, Semik LI [and others]. The role of intestinal dysbiozis in infringement of the function of the liver of rats after antibiotic therapy. Journal of Education, Health and Sport. 2018; 8(11): 518-524.
Gozhenko A. I. Advantages of high olein sunflower oil over palm oil according to biochemical research results / A. I. Gozhenko, A. P. Levitsky, V. T. Stepan, I. P. Pustovoit, N. S. Badiuk, A. K. Maslyukov - PhOL – PharmacologyOnLine - N 2. - P. 293-301. https://pharmacologyonline.silae.it/files/archives/2020/vol2/PhOL_2020_2_A028_Gozhenko.pdf
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