Clinically pathogenic aspects of the comprehensive treatment of burn scars
Keywordskeloid scars, hypertrophic scars, cryodestruction, xenotransplantation, laser genesis
Any deformities of general anatomical organization of the tissue at gradual deprivation of function can be relegated to the wounds which are relative to the pain syndrome and functional abnormality of the affected area of the body and cosmetic defects except for psycho-emotional disorders and they are also economic burdens for patients, their families and society. Thus short-term wound healing of high quality has high clinical value as it may lead to reduction in hospitalization and coming-back to the performance capability of patients . Dermal wound healing is a dynamic and highly adjustable process of cellular, humoral and molecular mechanisms which starts after the injury and it may last for years. The correlation of cells, growth promoting substances and cytokines ends with wound healing even if a sensitive balance between cells and mediators may be imperfect, the results of the investigative procedure shows that deficit of cellular factor or mediator can be compensated with other components which take part in wound healing, thus the reactivation may still take place. An inflammatory reaction is certain under the physiologic wound healing: cell lines, functions and mediators . The understanding of the sequence and chronology of processes of the wound healing, particularly the evolution of growth promoting substance and cytokine effects which leads to cell and tissue changes which are necessary for reparative processes, (Simpson and Ross, 1972; Leibovich and Ross, 1975) physiologic spatiotemporal changeability of sequential leucocyte form is shown by experiments (Martin 1997; Singer and Clark, 1999) and also the effect of competently selected corrective measures lets us achieve maximum impact of medical treatment.
Suggested compound method of correction of burn scars which combines cryosurgical method with xenotransplantation, injections of steroids in scars, laser genesis procedures and compression clothes with silicone plates guarantees high efficiency of treatment of burn scars.
Lazarus GS, Cooper DM, Knighton DR, Percoraro RE, Rodeheaver G, Robson MC: Definitions and guidelines for assessment of wounds and evaluation of healing. Wound Repair Regen 1994; 2: 165–170. https:
Eming SA, Krieg T, Davidson JM: Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007; 127: 514–525
Krafts KP: Tissue repair: the hidden drama. Organogenesis 2010; 6: 225–233
Gladstone, H.B., Berg, D., & McDonald, M. (2010). Scar revision. Dermatology Research and Practice, 2010, 545796. doi: 10.1155/2010/545796.
Stuart E Turvey, David H Broide Innate immunity The Journal of allergy and clinical immunology 125(2 Suppl 2):S24-32 2009 ;
Amanda MacLeod, Jonathan N. The Innate Immune System in Acute and Chronic Wounds Advances In Wound Care, Volume 5:65-78;
Kozynets H. P., Zhernov O. A., Zhernov A. O. Postburn scars, pathogenesis and methods of conservative treatment. Plastic and reconstructive surgery No 3–4, 2014. pp. 13-23
Abaev Y. K. Handbook of Surgery. Wounds and wound infection / Y. K. Abaev. – Rostov-on-Don: Feniks, 2006. – P. 427.
Belousov A. E. Scars and their correction / A. E. Belousov. – SPb.: Komandor-SPB, 2005. – 123 p.
Hlubokova I. B. Some aspects of postburn wound healing / I. B. Hlubokova // Annals of mergency and rehabilitation medicine. –2006. – T. 7, No 3. – P. 493.
J.M. Reinke H. Sorg Wound Repair and Regeneration Eur Surg Res 2012;49:35–43].
Burning Injury and Its Consequences. Guideline for Practitioners/ Endorsed by Kozynets H. P., Sliesarenko S. V., Sorokina O. Y., Klyhunenko O. M., Tsyhankov V. P. – Dnipropetrovsk, edition “Press of Ukraine” 2008. – P. 224.
Mateev M. A. Remodelling Management of Postburn Scar Deformities in Children / M. A. Mateev, H. C. Shaltakova // Pediatric Surgery. – 2009. – No 1. – P. 38-39
Methods of Conservative and Operative Rehabilitation of Surgical Patients with consequences of burns // H. P. Kozynets [and others]. – K.: SP “International Press-Polygraph Service”, 2010. – P. 100.
Polukarov N. Modern Methods of Pathological Scar Treatment and Scars Complications / N. Polukarov, V. Holubev // Doctor. – 2007. – No 2. – P. 59 – 62.
Pavlovych V. A. Treatment Practice and Preventive Measures of Keloid and Hypertrophic Scars in the Area of Face and Neck / V. A. Pavlovych, V. M. Ezrokhyn // Stomatology. – 2008. – No 2. – P. 46-49.]
Fistal N. M.) [ Ukrainian medical journal. Key considerations of clinical practice. №2(52) III - IV 2006
Alekseev A. A. Rehabilitation of Burn Sufferers / A. A. Alekseev, P. V. Saryhyn, S. V. Popov // Plastic Surgery: National Congress Material (Moscow, June 8-10 2011). – M.: OOO “Bionika Publishing House”. – 2011. – P. 13.
Problems of Diagnostic and Treatment of Pathological Scars / V. H. Myshalov, V. V. Khrapach, I. A. Nazarenko [and others] // Ukrainian Surgery. – 2008. – No 4. – P. 109-114.
Preventive Measures and Therapy of Scars Process of Soft Tissues / O. A. Danylov, V. F. Rybalchenko, A. M. Uryn [and others] // Pediatric Surgery. – 2006. – T. 3, No 1(10). – P. 67-73.
Berman B., Flores F. The treatment of hypertrophic scars and keloids // Eur. J. Dermatol. – 1998. – Vol. 8, No 8. – P. 591 – 595.
Mutalik S. Treatment of keloids and hypertrophic scars / S. Mutalik // Indian J. Dermatol. Venereol. Leprol. – 2005. – Vol. 71, No 1. – P. 3-8.].
Correction of scars / under the editorship of K. A. Arndt; edition of the series of George J. Dover; translated from English under general editorship of V. A. Visarinova]. – M.: OOO “Reed Elsevier”, 2009. – P. 101.;
Loannovich J., Panayotou R., Mantas N., Alexakis D. The treatment of burn scars: our experience. // Annals of MBC. – 1990. – Vol.3. – No 4. – P. 589 – 591.
Roseborough I. E. Prevention and treatment of excessive dermal scarring / I. E. Roseborough, M. A. Grevious, R. C. Lee // J. Natl. Med. Assoc. – 2004. – Vol. 96, No 1. – P. 108-116.]
How to Cite
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Number of views and downloads: 226
Number of citations: 0