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Journal of Education, Health and Sport

Expanding the knowledge of Helicobacter pylori – new directions, new challenges
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Expanding the knowledge of Helicobacter pylori – new directions, new challenges

Authors

  • Jakub Wronecki Chair and Department of Gastroenterology with Endoscopic Unit, Medical Univeristy of Lublin https://orcid.org/0000-0001-8664-7072
  • Ewa Tywanek Chair of Internal Medicine and Department of Internal Medicine in Nursing, Medical Univeristy of Lublin https://orcid.org/0000-0002-2311-994X
  • Paulina Trojanowska Department of Pediatric Neurology and Department of Endocrinology, Medical Univeristy of Lublin https://orcid.org/0000-0002-5289-6473
  • Barbara Skrzydło-Radomańska Chair and Department of Gastroenterology with Endoscopic Unit, Medical Univeristy of Lublin https://orcid.org/0000-0002-9047-1046
  • Agnieszka Zwolak Chair of Internal Medicine and Department of Internal Medicine in Nursing, Medical Univeristy of Lublin https://orcid.org/0000-0002-2556-4705
  • Robert Jan Łuczyk Chair of Internal Medicine and Department of Internal Medicine in Nursing, Medical Univeristy of Lublin https://orcid.org/0000-0003-0889-6326

DOI:

https://doi.org/10.12775/JEHS.2020.10.09.093

Keywords

Helicobacter pylori, genetics, pathogenicity, analysis,

Abstract

Introduction

Helicobacter pylori (H. pylori) infection is prevalent worldwide. As it is a known carcinogen, causing multitude of gastrointestinal end extra-gastric disorders, the eradication therapy is now indicated for every patient diagnosed with this infection. This approach may prove however to be improper, since it is now known, that not every strain of this species is pathogenic, therapy may be unsuccessful and drug resistance is ever increasing problem.

A brief description of the state of knowledge:

H. pylori is a species representing multiple strains with distinct regional genetic markup. Its prevalence is high in the general population, but in the recent years there have been reports of decreased presence in the developed countries. This paper reviews most important known genetic diversity markers and their impact on virulence and toxicity of species. It also covers possible new ways to combat the infection.

Conclusion

With increased possibility of genetic sequencing, there may be possibility for custom-tailored eradication therapy of H. pylori in the future.

References

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Urita, Y., Watanabe, T., Kawagoe, N., Takemoto, I., Tanaka, H., Kijima, S., Kido, H., Maeda, T., Sugasawa, Y., Miyazaki, T., Honda, Y., Nakanishi, K., Shimada, N., Nakajima, H., Sugimoto, M. and Urita, C. (2013), Helicobacter pylori status in large family. J Paediatr Child Health, 49: 394-398. doi:10.1111/jpc.12191

Thorell, K, Lehours, P, Vale, FF. Genomics of Helicobacter pylori. Helicobacter. 2017;22(Suppl. 1):e12409. https://doi.org/10.1111/hel.12409

Whitmire J.M., Merrell D.S. (2019) Helicobacter pylori Genetic Polymorphisms in Gastric Disease Development. In: Kamiya S., Backert S. (eds) Helicobacter pylori in Human Diseases. Advances in Experimental Medicine and Biology, vol 1149. Springer, Cham. https://doi.org/10.1007/5584_2019_365

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Hashemi SJ, Sheikh AF, Goodarzi H, et al. Genetic basis for metronidazole and clarithromycin resistance in Helicobacter pylori strains isolated from patients with gastroduodenal disorders. Infect Drug Resist. 2019;12:535-543. Published 2019 Mar 4. doi:10.2147/IDR.S192942

Alba, Claudioa,∗; Blanco, Anaa,∗; Alarcón, Teresaa,b Antibiotic resistance in Helicobacter pylori, Current Opinion in Infectious Diseases: October 2017 - Volume 30 - Issue 5 - p 489-497 doi: 10.1097/QCO.0000000000000396

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Published

2020-09-26

How to Cite

1.
WRONECKI, Jakub, TYWANEK, Ewa, TROJANOWSKA, Paulina, SKRZYDŁO-RADOMAŃSKA, Barbara, ZWOLAK, Agnieszka and ŁUCZYK, Robert Jan. Expanding the knowledge of Helicobacter pylori – new directions, new challenges. Journal of Education, Health and Sport. Online. 26 September 2020. Vol. 10, no. 9, pp. 770-776. [Accessed 4 July 2025]. DOI 10.12775/JEHS.2020.10.09.093.
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Vol. 10 No. 9 (2020)

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Review Articles

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