Chronic Fatigue Syndrome in children population – current knowledge summary
KeywordsChronic Fatigue Syndrome, fatigue, children.
Chronic Fatigue Syndrome/Myalgic Encephalomyelits (CFS/ME) is a chronic disease with complex pathophysiology and unknown etiology. It occurs both in children and adolescents, as well as in adults, with equal frequency. The clinical course is characterized by progressive fatigue, a significant reduction in the body's efficiency, lack of relief despite rest, and numerous accompanying symptoms. Pathognomonic symptom for PE is the increase in fatigue after physical or mental exertion and the persistence of these symptoms for several hours or days. The basis for effective treatment is primarily non-pharmacological treatment, including determining the optimal balance between physical activity and rest, which is aimed at preventing post-workout fatigue. Pain, insomnia, IO, and other symptoms can be treated with medication. So far, little research has been done on the diagnosis and treatment of this disease in children. This publication aims to summarize the knowledge currently available on the Chronic Fatigue Syndrome in children and adolescents.
Rowe, Peter C., et al. "Myalgic encephalomyelitis/chronic fatigue syndrome diagnosis and management in young people: a primer." Frontiers in pediatrics 5 (2017): 121.
Holmes, Gary P., et al. "Chronic fatigue syndrome: a working case definition." Annals of internal medicine 108.3 (1988): 387-389.
Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dobbins, J. G., Komaroff, A. "The chronic fatigue syndrome: a comprehensive approach to its definition and study." Annals of internal medicine 121.12 (1994): 953-959.
Kurowski, M., Kuna, P., "Zespół przewlekłego zmęczenia." Alergia Astma Immunolo.
Carruthers, Bruce M., et al. "Myalgic encephalomyelitis: international consensus criteria." Journal of internal medicine 270.4 (2011): 327-338.
Shepherd, Ch., Chaudhuri, A., ME/CFS/PVFS: An exploration of the key clinical issues. ME Association, 2018.
Oliver, L. M., Patel, K. "Co-morbid conditions in children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)–a retrospective case note review of a large cohort." Archives of Disease in Childhood 97.Suppl 1 (2012): A105-A105.
Nijhof, S.L., Maijer, K., Bleijenberg, G., et al. "Adolescent chronic fatigue syndrome: prevalence, incidence, and morbidity." Pediatrics 127.5 (2011): e1169-e1175.
Crawley, E.M., Emond, A.M., Sterne, J.A.C. "Unidentified Chronic Fatigue Syndrome/myalgic encephalomyelitis (CFS/ME) is a major cause of school absence: surveillance outcomes from school-based clinics." BMJ open 1.2 (2011): e000252.
Dowsett, E.G., Colby, J. "Long-term sickness absence due to ME/CFS in UK schools: an epidemiological study with medical and educational implications." Journal of Chronic Fatigue Syndrome 3.2 (1997): 29-42.
Crawley, E.M., Sterne, J.A. "Association between school absence and physical function in paediatric chronic fatigue syndrome/myalgic encephalopathy." Archives of Disease in Childhood 94.10 (2009): 752-756.
Smith, M.S., Martin‑Herz, S.P., Womack, W.M., Marsigan, J.L. "Comparative study of anxiety, depression, somatization, functional disability, and illness attribution in adolescents with chronic fatigue or migraine." Pediatrics 111.4 (2003): e376-e381.
Kennedy, G., Underwood, C., Belch, J.J.F. "Physical and functional impact of chronic fatigue syndrome/myalgic encephalomyelitis in childhood." Pediatrics 125.6 (2010): e1324-e1330.
Winger, A., Kvarstein, G., Wyller, V.B., et al. "Health related quality of life in adolescents with chronic fatigue syndrome: a cross-sectional study." Health and Quality of Life Outcomes 13.1 (2015): 96.
Rimes, K.A., et al. "Incidence, prognosis, and risk factors for fatigue and chronic fatigue syndrome in adolescents: a prospective community study." Pediatrics 119.3 (2007): e603-e609.
Bombardier, C.H., Buchwald, D., "Chronic fatigue, chronic fatigue syndrome, and fibromyalgia: disability and health-care use." Medical care (1996): 924-930.
Knight, S., et al. "Paediatric chronic fatigue syndrome: complex presentations and protracted time to diagnosis." Journal of paediatrics and child health 49.11 (2013): 919-924.
Underhill, R.A., O'gorman, R. "Prevalence of chronic fatigue syndrome and chronic fatigue within families of CFS patients." Journal of Chronic Fatigue Syndrome 13.1 (2006): 3-13.
Buchwald D., Herrell R., Ashton S., et al "A twin study of chronic fatigue." Psychosomatic medicine 63.6 (2001): 936-943.
Barron D.F., Cohen B.A., Geraghty M.T., Violand R., Rowe P.C Barron, Diana F., et al. "Joint hypermobility is more common in children with chronic fatigue syndrome than in healthy controls." The Journal of pediatrics 141.3 (2002): 421-425.
Katz B.Z., Shiraishi Y., Mears C.J., Binns H.J., Taylor R., et al. "Chronic fatigue syndrome after infectious mononucleosis in adolescents." Pediatrics 124.1 (2009): 189-193.
Sulheim D.E., Fagermoen E., Winger A., et al.: "Disease mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-sectional and randomized clinical trial." JAMA pediatrics 168.4 (2014): 351-360.
Diaz‑Mitoma F., Turgonyi E., Kumar A., et al. "Clinical improvement in chronic fatigue syndrome is associated with enhanced natural killer cell-mediated cytotoxicity: the results of a pilot study with Isoprinosine®." Journal of Chronic Fatigue Syndrome 11.2 (2003): 71-95.
Scully, P., McKernan, D. P., Keohane, J., Groeger, D., Shanahan, F., Dinan, T. G., Quigley, E. M. "Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity." American Journal of Gastroenterology 105.10 (2010): 2235-2243.
Clarke, G., Quigley, E. M., Cryan, J. F., Dinan, T. G. "Irritable bowel syndrome: towards biomarker identification." Trends in molecular medicine 15.10 (2009): 478-489.
Gaab, J., Rohleder, N., Heitz, V., Engert, V., Schad, T., Schürmeyer, T. H., Ehlert, U. "Stress-induced changes in LPS-induced pro-inflammatory cytokine production in chronic fatigue syndrome." Psychoneuroendocrinology 30.2 (2005): 188-198.
Raber, J., Sorg, O., Horn, T. F. W., Yu, N., Koob, G. F., Campbell, I. L., Bloom, F. E. "Inflammatory cytokines: putative regulators of neuronal and neuro-endocrine function." Brain research reviews 26.2-3 (1998): 320-326.
Jiménez, M. B. "Treatment of irritable bowel syndrome with probiotics. An etiopathogenic approach at last." Rev Esp Enferm Dig (Madrid) 101 (2009): 553-564.
Bailey, M. T., Lubach, G. R., & Coe, C. L. "Prenatal stress alters bacterial colonization of the gut in infant monkeys." Journal of pediatric gastroenterology and nutrition 38.4 (2004): 414-421.
Riedel, C. U., Foata, F., Philippe, D., Adolfsson, O., Eikmanns, B. J., Blum, S. "Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation." World journal of gastroenterology: WJG 12.23 (2006): 3729.
Maes, M., Mihaylova, I., Leunis, J. C. "Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut–intestinal permeability." Journal of affective disorders 99.1-3 (2007): 237-240.
Maes, M., Twisk, F. N. "Chronic fatigue syndrome: Harvey and Wessely's (bio) psychosocial model versus a bio (psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways." BMC medicine 8.1 (2010): 35.
Myhill, S., Booth, N. E., McLaren-Howard, J. "Chronic fatigue syndrome and mitochondrial dysfunction." International journal of clinical and experimental medicine 2.1 (2009): 1.
Sheedy, J. R., Wettenhall, R. E., Scanlon, D., Gooley, P. R., Lewis, D. P., Mcgregor, N., De Meirleir, K. L. "Increased d-lactic acid intestinal bacteria in patients with chronic fatigue syndrome." In Vivo 23.4 (2009): 621-628.
Jammes, Y., Steinberg, J. G., Mambrini, O., Bregeon, F., Delliaux, S. "Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise." Journal of internal medicine 257.3 (2005): 299-310.
Rowe, P.C., Bou‑Holaigh, I., Kan, J.S., Calkins, H. "Is neurally mediated hypotension an unrecognised cause of chronic fatigue?." The Lancet 345.8950 (1995): 623-624.
Stewart, J.M., Gewitz, M.H., Weldon, A., et al. "Orthostatic intolerance in adolescent chronic fatigue syndrome." Pediatrics 103.1 (1999): 116-121.
Stewart, J.M., Medow, M.S., Messer, Z.R., et al. "Postural neurocognitive and neuronal activated cerebral blood flow deficits in young chronic fatigue syndrome patients with postural tachycardia syndrome." American Journal of Physiology-Heart and Circulatory Physiology 302.5 (2012): H1185-H1194.
Rowe, K.S., Moon, J. "What is the natural history of chronic fatigue syndrome in young people? Oral presentation IACFS/ME conference Ottawa." Bull IACFS/ME Fall (2011): 129.
Bell, D.S., Jordan, K., Robinson, M. "Thirteen-year follow-up of children and adolescents with chronic fatigue syndrome." Pediatrics 107.5 (2001): 994-998.
How to Cite
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Number of views and downloads: 251
Number of citations: 0