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Journal of Education, Health and Sport

Adiponectin as novel biomarker of endothelial dysfunction in insulin resistance and obesity – a narrative review
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  • Adiponectin as novel biomarker of endothelial dysfunction in insulin resistance and obesity – a narrative review
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Adiponectin as novel biomarker of endothelial dysfunction in insulin resistance and obesity – a narrative review

Authors

  • Joanna Szydełko Medical University of Lublin https://orcid.org/0000-0003-3744-9058
  • Paulina Trojanowska Medical University of Lublin https://orcid.org/0000-0002-5289-6473
  • Izabela Dąbrowska Medical University of Lublin https://orcid.org/0000-0003-1593-2284
  • Magdalena Szydełko-Gorzkowicz Independent Public Clinical Hospital No. 4 in Lublin https://orcid.org/0000-0001-6216-9934
  • Michał Litwińczuk Farmed Non-Public Healthcare Institution, Lublin https://orcid.org/0000-0002-4086-6779

DOI:

https://doi.org/10.12775/JEHS.2020.10.09.071

Keywords

adiponectin, insulin resistance, obesity, vascular dysfunction

Abstract

Introduction: Obesity is a chronic fatal disease with still growing incidence among children, adolescents, and adults worldwide. The subclinical inflammatory process together with hipoadiponectinemia may lead to the development of various comorbidities, including cardiovascular complications. That is why, the relationship between adipose tissue activity, obesity, insulin resistance, and endothelial function is in high interest and an object of extensively studies.

Aim of the study: This article summarizes the current knowledge on the anti-atherogenic effects of adiponectin and its properties to improve endothelial function in obesity-related insulin resistance.

Description of knowledge: Adiponectin, an adipose tissue-derived pleiotropic hormone with anti-inflammatory, anti-atherogenic, anti-diabetic, and insulin-sensitizing actions, is not only engaged in modulation of type 2 diabetes mellitus, hypertension or coronary artery disease, but the latest researches highlight its role in improving vascular wall integrity. It affects complex signaling pathways in endothelial cells and influence inflammatory responses in the subendothelial space. Pre-clinical and clinical studies suggest that agents leading to increase in adiponectin levels, simultaneously contribute to decrease insulin resistance, and improve endothelial dysfunction.

Conclusions: Adiponectin may be a predictive factor of endothelial dysfunctionality and vascular remodeling development in the group of patients with overweight, obesity, and insulin resistance. Discovering pharmacological agents and non-pharmacological interventions that increase the level of circulating adiponectin will become novel and innovative therapeutic strategy to ameliorate obesity-related comorbidities. Therefore, further studies are required to determine the exact role of adiponectin in the pathogenesis of metabolic diseases.

Author Biographies

Joanna Szydełko, Medical University of Lublin

Department of Endocrinology

Paulina Trojanowska, Medical University of Lublin

Department of Endocrinology, Department of Pediatric Neurology

Izabela Dąbrowska, Medical University of Lublin

Department of Interventional Radiology and Neuroradiology

Magdalena Szydełko-Gorzkowicz, Independent Public Clinical Hospital No. 4 in Lublin

Independent Public Clinical Hospital No. 4 in Lublin, Poland

Michał Litwińczuk, Farmed Non-Public Healthcare Institution, Lublin

Endocrinology Outpatient Clinic

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2020-09-23

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1.
SZYDEŁKO, Joanna, TROJANOWSKA, Paulina, DĄBROWSKA, Izabela, SZYDEŁKO-GORZKOWICZ, Magdalena & LITWIŃCZUK, Michał. Adiponectin as novel biomarker of endothelial dysfunction in insulin resistance and obesity – a narrative review. Journal of Education, Health and Sport [online]. 23 September 2020, T. 10, nr 9, s. 591–606. [accessed 4.6.2023]. DOI 10.12775/JEHS.2020.10.09.071.
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Vol. 10 No. 9 (2020)

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Review Articles

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