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Journal of Education, Health and Sport

Mantle Cell Lymphoma: Effectiveness of Maintenance Ibrutinib – Case Report
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Mantle Cell Lymphoma: Effectiveness of Maintenance Ibrutinib – Case Report

Authors

  • Danuta Krasowska Students’ Scientific Association at the Department of Dermatology, Venerology and Pediatric Dermatology, Medical University of Lublin https://orcid.org/0000-0002-3015-1120
  • Aleksandra Szczepnek Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, ul. Staszica 11, 20-080 Lublin https://orcid.org/0000-0003-3953-1784
  • Magdalena Kozioł Student Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080 https://orcid.org/0000-0002-8671-5968
  • Ewa Szczepanek-Wąsik Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, ul. Staszica 11, 20-080 Lublin https://orcid.org/0000-0002-9715-3745

DOI:

https://doi.org/10.12775/JEHS.2020.10.09.034

Keywords

mantle cell lymphoma, ibrutinib, maintenance therapy

Abstract

Mantle cell lymphoma is a rare subtype of non- Hodgkin lymphoma with life-threatening course of disease. It mostly affects older adults in their sixth or seventh decade of life with male to female predominance of 3 to 1. It prognosis is very poor and the treatment is demanding. The golden standard therapy for younger, fit patients <65 years is chemoimmunotherapy such as R-CHOP/R-DHAP rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, prednisolone, dexamethasone, cytarabine and cisplatin) followed by BEAM chemotherapy (carmustine, etoposide, cytarabine, melphalan)  and autologous- stem-cell transplant (ASCT).  Nevertheless MCL is mainly recognized in patients of average age 67 in whom comorbidities often play a crucial role during treatment.

A 56- years old patient was admitted to the Department of Hematooncology and Bone Marrow Transplantation with clinical symptoms such as heavy night sweats, generalized enlargement of lymph nodes, massive weight loss, dyspnea and fatigue. Initial physical examination and imaging showed enormous hepatosplenomegaly, mass in the lungs and fluid in the pleural cavity.

The patients underwent chemioimmunotherapy consolidated with an autologous stem cell transplant. To date, the patient is on maintenance treatment with ibrutinib.

References

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Jerkeman M, Eskelund CW, Hutchings M, et al. Ibrutinib, lenalidomide, and rituximab in relapsed or refractory mantle cell lymphoma (PHILEMON): a multicentre, open-label, single-arm, phase 2 trial. Lancet 2018;5: 109-116

Yan F, Gopal AK, Graf S. Targeted drugs as maintenance therapy after autologous stem cell transplantation in patients with mantle cell lymphoma. Pharmaceuticals 2017, 10: 1-11.

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Published

2020-09-22

How to Cite

1.
KRASOWSKA, Danuta, SZCZEPNEK, Aleksandra, KOZIOŁ, Magdalena and SZCZEPANEK-WĄSIK, Ewa. Mantle Cell Lymphoma: Effectiveness of Maintenance Ibrutinib – Case Report. Journal of Education, Health and Sport. Online. 22 September 2020. Vol. 10, no. 9, pp. 299-307. [Accessed 5 July 2025]. DOI 10.12775/JEHS.2020.10.09.034.
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Vol. 10 No. 9 (2020)

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Case Reports

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