The role of sorbents and probiotics in the prevention of structural-morphological disorders in mice with dysbiosis on the background of virus-bacterial infection
Keywordsdysbiosis, infection, probiotics, sorbents, viruses
Interest in the study of probiotics has grown significantly in recent years. One of the reasons for such increased attention to this problem is the results of numerous experimental studies, which show the important role of individual representatives of the normal microbiota in the aetiology and pathogenesis of many infections and even somatic human diseases. However, the violation of microbial ecology, as a rule, is accompanied by pollution of the internal environment of the body with toxic compounds of both exogenous and endogenous nature, so enterosorbents are among main approaches of improving the normal microbiota.
The experiments allowed to establish a pronounced hepatoprotective function of the sorbent “Smektovit”, which is manifested by a decrease in destructive changes that accompany the process of modelling viral and bacterial infections on the background of dysbiosis. In addition, the results of the presented studies showed the ability of probiotic “multiprobiotic Symbiter®” and sorbent “Smectovit” to reduce deep cytodestructive messages in the simulation of viral and bacterial infections at the rate of dysbiosis and normalization of immune responses, as they accompany such processes. At the same time, it is noted that the preventive effect of probiotics is more pronounced in the intestine, and sorbents – in the liver.
Shirobokov V. P., Yankovskiy D. S., Dyiment G. S. Microbes in biogeochemical processes, evolution of the biosphere and the existence of mankind (2014).. Kyiv: Veres O.I.; 464 p..
Kravchuk R.I., Shejbak V.M., Zhmakin A.I., Goreckij M.V., Egorov A.S. (2007). Characteristics of ultrastructural changes in the mucosa of the jejunum after acetaminophen-induced dysbacteriosis in rats. Journal of the Grodno State Medical University, (1), 106-109.
Johnson C.D., Kudsk K.A. (1999). Nutritional and intestinal mucosal immunity. Clin. Nutr., 18 (6), 337-344.
Bobyr V.V., Ponyatovsky V.A., Djugikowa E.M., Shyrobokov V.P. (2015). Modeling of dysbiotic disorders with laborat ory animals. Biomedical and Biosocial Anthropology, 26, 230-233.
Yevtushenko O. I. Enteroviruses in pathology of the fetus and newborn : Dissertation for the degree of Doctor of Medicine : 03.00.06. Bogomolets National Medical University, Kyiv, 2007. 302 p.
How to Cite
LicenseThe periodical offers access to content in the Open Access system under the Creative Commons non-exclusive license (CC BY-ND 4.0).
Number of views and downloads: 64
Number of citations: 0