Withania somnifera (Ashwagandha) a plant of many possibilities
KeywordsWithania somnifera, Vitanoside IV, Glycowithanolides withaferin-A, Sitoindosides IX and X, Isopelletierine, Solanaceae
Ashwagandha (Withania somnifera) has been long used in the traditional Ayurvedic system of medicine to enhance various kinds of disease processes and specially as a nervine tonic. Nowadays, its beneficial activities are still being searched.
Doughty KN, Del Pilar NX, Audette A, Katz DL. Curr Cardiol Rep. 2017 Oct 4;19(11):116.
P. C. Shah*, N. A. Trivedi, J. D. Bhatt And K. G. Hemavathi, Effect of Withania Somnifera on forced swimming test induced immobility in mice and its interaction with various drugs; Indian J Physiol Pharmacol 2006; 50 (4) : 409–415
Salve J, Pate S, Debnath K, Langade D. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus. 2019;11(12):e6466.
Narendra Singh, Mohit Bhalla, Prashanti de Jager, Marilena Gilca, An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda, Afr J Tradit Complement Altern Med. 2011; 8(5 Suppl): 208–213.
Bhattacharya SK, Goel RK, Kaur R, Ghosal S. Anti - stress activity of Sitoindosides VII and VIII. New Acylsterylglucosides from Withania somnifera. Phytother Res. 1987;1:32–37.
Kuboyam A T, Tohda C, Komatsu K. Withanoside IV and its active metabolite, sominone, attenuate A beta(25–35)-induced neurodegeneration. Eur J Neurosci. 2006;23(6):1417–1426.
Abdel-Magied EM, Abdel-Rahman HA, Harraz FM. The effect of aqueous extracts of Cynomorium coccineum and Withania somnifera on testicular development in immature Wistar rats. J Ethnopharmacol. 2001;75:1–4.
Singh N, Agarwal AK, Lata A, Kohli RP. Evaluation of ‘adaptogenic’ properties of Withania somnifera. Proc Indian Pharmacological Society. 1976;17
Singh N, Agarwal AK, Lata A, Kohli RP. XIIth Scientific Seminar on Indian Medicine. Vol. 4. Varanasi: Institute of Medical Sciences; 1977. Experimental evaluation of ‘adaptogenic’ properties of Withania somnifera.
. Singh N. A new concept on the possible therapy of stress disease with ‘Adaptogens’ (Anti-stress drugs) of indigenous plant origin. Curr Med Prac. 1981;25:50–55.
Singh N, Singh SP, Sinha JN, Shanker K, Kohli RP. Withania somnifera (Ashwagandha) A rejuvenator herbal drug which enhances survival during stress (An adaptogen) Int J Crude Drug Res. 1982;3:29–35.
. Singh N, Singh SP, Nath C, Kohli RP, Bhargava KP. 5 th Sepal Congress of Rheumatology. Bangkok: 1984. Anti-stress plants as anti-rheumatic agents; p. 37.
Singh N. A pharmaco-clinical evaluation of some Ayurvedic crude plant drugs as anti-stress agents and their usefulness in some stress diseases of man. Ann Nat Acad Ind Med. 1986;2(1):14–26.
Singh N, Singh SP, Dixit KS, Saxena RC, Kohli RP. A Placebo Controlled Clinical Trial of Cyprus rotundus, Withania somnifera and their Combination in cases of Rheumatoid Arthritis. Proc International Seminar. 1986a;2:18–21.
Singh N, Gilca M. Herbal Medicine - Science embraces tradition - a new insight into the ancient Ayurveda. Germany: Lambert Academic Publishing; 2010. pp. 51–67.
Abbas SS, Bhalla M, Singh N. Proc workshop on essential medicines, adverse drug reactions and therapeutic drug monitoring. Lucknow: Scientific Convention Centre; 2005. A clinical study of Organic Ashwagandha in some cases of uterine tumors (fibroids) and dermatofibrosarcoma; pp. 143–144.
Dixit KS, Agarwal AK, Seth PK, Singh N. World Congress on Biotech Dev Med Subs Plants & Marine Origin. Lucknow (India): King George Medical College; 1995. Effect of Withania somnifera, Panex ginseng and Cannabis indica and radio ligand binding with neurohumoral in the CNS; p. 141.
MURTHY MNK, GUNDAGANI S, NUTALAPATI C, PINGALI U. Evaluation of Analgesic Activity of Standardised Aqueous Extract of Withania somnifera in Healthy Human Volunteers using Mechanical Pain Model. Journal of Clinical & Diagnostic Research. 2019;13(1):1-4.
Sakka Mazen E, Pavelescu M, Grigorescu E. Contributions to the pharmacodynamic study of roots of Withania somnifera Dun species of Pakistani origin. Note III: Testing of analgesic activity of dichlormethanic and methanolic extract from Withania somnifera roots. Rev Med Chir Soc Med Nat Iasi. 1990;94(3-4):603-605.
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