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Journal of Education, Health and Sport

Mechanisms linking obesity and gastrointestinal cancers
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  3. Vol. 10 No. 8 (2020) /
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Mechanisms linking obesity and gastrointestinal cancers

Authors

  • Blanka Świerczyńska Student Research Group of Oncological Surgery, Medical University of Lublin https://orcid.org/0000-0001-8782-8625
  • Michał Sekuła Student Research Group of Oncological Surgery, Medical University of Lublin https://orcid.org/0000-0001-8378-9964
  • Krzysztof Smoluchowski Student Research Group of Oncological Surgery, Medical University of Lublin https://orcid.org/0000-0001-9237-3346
  • Magdalena Suchodolska Student Research Group of Oncological Surgery, Medical University of Lublin https://orcid.org/0000-0002-1995-5136
  • Adrian Undziakiewicz Student Research Group of Oncological Surgery, Medical University of Lublin https://orcid.org/0000-0002-1191-1366

DOI:

https://doi.org/10.12775/JEHS.2020.10.08.041

Keywords

obesity, gastrointestinal cancers, mechanisms of carcinogenesis.

Abstract

Introduction and purpose: The worldwide prevalence of obesity increased threefold between 1975 and 2016. Obesity is a risk factor for gastrointestinal cancers, including the pancreas, liver, esophagus, colorectum, stomach cardia, and gallbladder. This work is an analysis of the available PubMed literature on relationship between obesity and gastrointestinal cancers and possible mechanisms linking them.

Brief description of the state of knowledge: There is a number of mechanisms responsible for obesity associated gastrointestinal cancers. Excess adiposity leads to: metabolic syndrome, chronic inflammation, altered production of steroid hormones and adipokines as well as changes in insulin and IGF1 signaling. This study examines the processes leading to obesity-associated colorectal, esophageal, gastric, and pancreatic cancers, which are known to be the most prevalent and lethal cancers worldwide. In this review, the mechanisms of gastrointestinal cancerogenesis such as changes in insulin and insulin-like growth factor signaling pathways, chronic inflammation associated to obesity, altered adipokine and inflammatory factors levels, are being discussed.

Conclusions: Thorough understanding of the biological processes connecting obesity, metabolic health and gastrointestinal cancers may help to discover new risk factors and biomarkers, improve preventive strategies and invent ground-breaking treatment.

Key words: obesity; gastrointestinal cancers; mechanisms of carcinogenesis.

Author Biographies

Blanka Świerczyńska, Student Research Group of Oncological Surgery, Medical University of Lublin

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Michał Sekuła, Student Research Group of Oncological Surgery, Medical University of Lublin

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Krzysztof Smoluchowski, Student Research Group of Oncological Surgery, Medical University of Lublin

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Magdalena Suchodolska, Student Research Group of Oncological Surgery, Medical University of Lublin

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Adrian Undziakiewicz, Student Research Group of Oncological Surgery, Medical University of Lublin

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Published

2020-08-23

How to Cite

1.
ŚWIERCZYŃSKA, Blanka, SEKUŁA, Michał, SMOLUCHOWSKI, Krzysztof, SUCHODOLSKA, Magdalena and UNDZIAKIEWICZ, Adrian. Mechanisms linking obesity and gastrointestinal cancers. Journal of Education, Health and Sport. Online. 23 August 2020. Vol. 10, no. 8, pp. 346-354. [Accessed 14 May 2025]. DOI 10.12775/JEHS.2020.10.08.041.
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Vol. 10 No. 8 (2020)

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Review Articles

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