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Journal of Education, Health and Sport

Pregnancy-associated breast cancer - diagnosis, treatment and outcomes for women and their offspring
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  4. Review Articles

Pregnancy-associated breast cancer - diagnosis, treatment and outcomes for women and their offspring

Authors

  • Martyna Maria Zielińska Students’ Scientific Association, Oncological Surgery Department, Medical University, Lublin https://orcid.org/0000-0001-8886-8274
  • Natalia Zarankiewicz Students’ Scientific Association, Oncological Surgery Department, Medical University, Lublin https://orcid.org/0000-0001-9203-3376
  • Aleksandra Kuchnicka Students’ Scientific Association, Oncological Surgery Department, Medical University, Lublin https://orcid.org/0000-0001-8481-7592
  • Katarzyna Kosz Students’ Scientific Association, Oncological Surgery Department, Medical University, Lublin https://orcid.org/0000-0001-6848-0598
  • Bogumiła Ciseł Oncological Surgery Department, Independent Public Teaching Hospital No. 1, Lublin; Medical University, Lublin https://orcid.org/0000-0001-6970-1698

DOI:

https://doi.org/10.12775/JEHS.2020.10.08.029

Keywords

pregnancy-associated breast cancer, breast cancer, prognosis, pregnancy, breast cancer treatment

Abstract

Introduction: Pregnancy-associated breast cancer (PABC) is the most common malignancy in pregnant women with an incidence of 1 in 3-10 thousand pregnancies. It is mostly defined as breast cancer diagnosed during pregnancy or within 1 year postpartum. The number of PABCs is going to raise due to the trend of delaying childbearing. 

Purpose: This review summarizes data on the occurrence and characteristics of PABC. The analysis comprises diagnosis and proper treatment of BC during pregnancy. Prognosis of women and their offspring are emphasized. 

Material and methods: The review is based on publications mainly from 2010 to 2019 and 5 articles from 1994-2008 collected on the PubMed.  

Results: The sensitivity of breast ultrasonography (USG) in pregnancy is 70-100% and it is considered as safe for the fetus. Staging evaluation in pregnant women consists of chest x-ray, liver USG and non-contrast bone MRI. 71-88% of PABCs are invasive ductal carcinomas. Treatment consists of breast surgery regardless of time and optionally, chemotherapy from the 2nd trimester. Radiotherapy, tamoxifen and trastuzumab are contraindicated in PABC. Therapeutic abortion does not improve oncological outcome. Overall prognosis is similar for both pregnant and non-pregnant patients with similar type and stage of BC. The rate of congenital malformations is 1,3% for both children of PABC patients treated with chemotherapy and born from women without chemotherapeutic treatment. The most frequent obstetrical complication of PABC treatment is preterm delivery. 

Conclusions: Pregnancy does not impact oncologic outcome, if the treatment is appropriate. PABC patients have survival rates consistent with the stage of disease. Proper treatment of PABC does not increase the risk of congenital malformations and is relatively safe for the fetus.  

Author Biography

Bogumiła Ciseł, Oncological Surgery Department, Independent Public Teaching Hospital No. 1, Lublin; Medical University, Lublin

Assistant/MD, PhD (Department of Surgical Oncology)

References

Pugh AM, Giannini CM, Pinney SM, Hanseman DJ, Shaughnessy EA, Lewis JD. Characteristics and diagnosis of pregnancy and lactation associated breast cancer: Analysis of a self-reported regional registry. Am J Surg. 2018;216(4):809-812. doi: 10.1016/j.amjsurg.2018.07.060.

Lambe M, Hsieh CC, Trichopoulos D, Ekbom A, Pavia M, Adami HO. Transient increase in the risk of breast cancer after giving birth. N Engl J Med. 1994;331:5-9.

Ruiz R, Herrero C, Strasser-Weippl K, Touya D, St Louis J, Bukowski A et al. Epidemiology and pathophysiology of pregnancy-associated breast cancer: A review. Breast. 2017;35:136-141. doi: 10.1016/j.breast.2017.07.008.

Martinez MT, Bermejo B, Hernando C, Gambardella V, Cejalvo JM, Lluch A. Breast cancer in pregnant patients: A review of the literature. Eur. J. Obstet. Gynecol. Reprod. Biol. 2018;230:222-227. doi.org/10.1016/j.ejogrb.2018.04.029.

Becker S. Breast cancer in pregnancy: A brief clinical review. Best Pract Res Clin Obstet Gynaecol. 2016;33:79-85. doi: 10.1016/j.bpobgyn.2015.10.013.

Córdoba O, Llurba E, Saura C, Rubio I, Ferrer Q, Cortés J et al. Multidisciplinary approach to breast cancer diagnosed during pregnancy: maternal and neonatal outcomes. Breast. 2013;22(4):515-9. doi: 10.1016/j.breast.2012.10.005.

Cordeiro C, Gemignani M. Breast Cancer in Pregnancy: Avoiding Fetal Harm When Maternal Treatment Is Necessary. Breast J. 2017;23(2):200–205. doi:10.1111/tbj.12780.

Langer A, Mohallem M, Stevens D, Rouzier R, Lerebours F, Cherel P. A single-institution study of 117 pregnancy-associated breast cancers (PABC): Presentation, imaging, clinicopathological data and outcome. Diagn Interv Imaging. 2014;95(4):435–41. doi: 10.1016/j.diii.2013.12.021.

Kanal E, Barkovich AJ, Bell C, et al. ACR guidance document for safe MR practices: 2007. A J Roentgenol. 2007;188:1447-1474. doi: 10.2214/AJR.06.1616.

Amant F, Loibl S, Neven P, Van Calsteren K. Breast cancer in pregnancy. Lancet Oncol. 2012;379:570-579. doi: 10.1016/S1470-2045(11)70363.-1.

Gropper AB, Zabicki Calvillo K, Dominici L, Troyan S, Rhei E, Economy KE et al. Sentinel Lymph Node Biopsy in Pregnant Women With Breast Cancer. Ann Surg Oncol. 2014;21(8):2506-2511. doi: 10.1245/s10434-014-3718-2.

Genin AS, Lesieur B, Gligorov J, Antoine M, Selleret L, Rouzier R. Pregnancy-associated Breast Cancers: Do They Differ From Other Breast Cancers in Young Women? Breast. 2012;21(4):550-555. doi: 10.1016/j.breast.2012.05.002.

Genin AS, Rycke Y, Stevens D, Donnadieu A, Langer A, Rouzier R et al. Association With Pregnancy Increases the Risk of Local Recurrence but Does Not Impact Overall Survival in Breast Cancer: A Case-Control Study of 87 Cases. Breast. 2016;30:222-227. doi: 10.1016/j.breast.2015.09.006.

Zagouri F, Sergentanis TN, Chrysikos D, Papadimitriou CA, Dimopoulos MA, Bartsch R. Trastuzumab administration during pregnancy: a systematic review and meta-analysis. Breast Cancer Res Treat. 2013;137(2):349–357. doi:10.1111/tbj.12780.

Grimm D, Woelber L, Trillsch F, Keller-v Amsberg G, Mahner S. Clinical management of epithelial ovarian cancer during pregnancy. Eur J Cancer. 2014;50(5):963–971. doi: 10.1016/j.ejca.2013.12.020.

Fajdic J, Gotovac N, Hrgovic Z, Fassbender WJ. Diagnosis and therapy of gestational breast cancer: a review. Adv Med Sci. 2008;53(2):167–171. doi: 10.1111/tbj.12780

Lohsiriwat V, Peccatori FA, Martella S, Azim HA Jr, Sarno MA, Galimberti V et al. Immediate breast reconstruction with expander in pregnant breast cancer patients. Breast. 2013;22(5):657– 660. doi: 10.1016/j.breast.2013.06.005.

Loibl S, Schmidt A, Gentilini O, Kaufman B, Kuhl C, Denkert C et al. Breast cancer diagnosed during pregnancy: adapting recent advances in breast cancer care for pregnant patients. JAMA Oncol. 2015;1(8):1145-1153. doi: 10.1001/jamaoncol.2015.2431

Toesca A, Gentilini O, Peccatori F, Azim HA, Amant F. Locoregional treatment of breast cancer during pregnancy. Gynecol Surg. 2014;11:279–284. doi: 10.1007/s10397-014-0860-6.

Azim Jr. HA, Del Mastro L, Scarfone G, Peccatori FA. Treatment of breast cancer during pregnancy: regimen selection, pregnancy monitoring and more. Breast. 2011;20:1–6. doi.org/10.1016/j.breast.2010.10.008

Amant F, Van Calsteren K, Halaska MJ, Gziri MM, Hui W, Lagae L, et al. Long-term cognitive and cardiac outcomes after prenatal exposure to chemotherapy in children aged 18 months or older: an observational study. Lancet Oncol. 2012;13(3):256–264. doi: 10.1016/S1470-2045(11)70363-1.

Hahn KM, Johnson PH, Gordon N. Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero. Cancer. 2006;107(6):1219–1226. doi: 10.1002/cncr.22081

Framarino-dei-Malatesta M, Piccioni MG, Brunelli R, Iannini I, Cascialli G, Sammartino P. Breast cancer during pregnancy: a retrospective study on obstetrical problems and survival. Eur J Obstet Gynecol Reprod Biol. 2014;173:48-52. Doi.org/10.1016/j.ejogrb.2013.11.017

Guidroz JA, Scott-Conner CE, Weigel RJ. Management of pregnant women with breast cancer. J Surg Oncol 2011;103:337-340. doi: 10.1002/jso.21673

Amant F, Brepoels L, Halaska MJ, Gziri MM, Calsteren KV. Gynaecologic cancer complicating pregnancy: an overview. Best Pract Res Clin Obstet Gynaecol. 2010;24(1):61–79. doi: 10.1016/j.bpobgyn.2009.08.001

Aviles A, Neri N. Hematologic malignancies and pregnancy: a final report of 84 children who received chemotherapy in utero. Clin Lymphoma. 2001;2(3)173–177. doi: 10.3816/CLM.2001.n.023

Maor GS, Czuzoj-Schulman N, Spence AR, Abenhaim HA. Neonatal outcomes of pregnancy-associated breast cancer: Population-based study on 11 million births. Breast J. 2019;25(1):86-90. doi: 10.1111/tbj.13156

Peccatori FA, Azim HA. Managing pregnancy-associated breast cancer: Is more really better? Breast. 2016;30:215-216. doi: 10.1016/j.breast.2016.06.006

Litton JK, Warneke CL, Hahn KM, Palla SL, Kuerer HM, Perkins GH et al. Case control study of women treated with chemotherapy for breast cancer during pregnancy as compared with nonpregnant patients with breast cancer. Oncologist. 2013;18(4):369–376. doi: 10.1634/theoncologist.2012-0340

Azim HA, Santoro L, Russell-Edu W, Pentheroudakis G, Pavlidis N, Peccatori A. Prognosis of pregnancy-associated breast cancer: A meta-analysis of 30 studies. Cancer Treat Rev. 2012;38(7):834-842. doi: 10.1016/j.ctrv.2012.06.004

Van den Rul N, Han SN, Van Calsteren K, Neven P, Amant F. Postpartum breast cancer behaves differently. Facts Views Vis Obgyn. 2011;3(3):183–188.

Eng Lee G, Mayer EL, Partridge A. Prognosis of pregnancy-associated breast cancer. Breast Cancer Res Treat. 2017;163:417–421. doi: 10.1007/s10549-017-4224-6

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Published

2020-08-20

How to Cite

1.
ZIELIŃSKA, Martyna Maria, ZARANKIEWICZ, Natalia, KUCHNICKA, Aleksandra, KOSZ, Katarzyna and CISEŁ, Bogumiła. Pregnancy-associated breast cancer - diagnosis, treatment and outcomes for women and their offspring. Journal of Education, Health and Sport. Online. 20 August 2020. Vol. 10, no. 8, pp. 251-259. [Accessed 3 July 2025]. DOI 10.12775/JEHS.2020.10.08.029.
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