Pregnancy-associated breast cancer - diagnosis, treatment and outcomes for women and their offspring
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  • Pregnancy-associated breast cancer - diagnosis, treatment and outcomes for women and their offspring

Pregnancy-associated breast cancer - diagnosis, treatment and outcomes for women and their offspring

Authors

  • Martyna Maria Zielińska Students’ Scientific Association, Oncological Surgery Department, Medical University, Lublin https://orcid.org/0000-0001-8886-8274
  • Natalia Zarankiewicz Students’ Scientific Association, Oncological Surgery Department, Medical University, Lublin https://orcid.org/0000-0001-9203-3376
  • Aleksandra Kuchnicka Students’ Scientific Association, Oncological Surgery Department, Medical University, Lublin https://orcid.org/0000-0001-8481-7592
  • Katarzyna Kosz Students’ Scientific Association, Oncological Surgery Department, Medical University, Lublin https://orcid.org/0000-0001-6848-0598
  • Bogumiła Ciseł Oncological Surgery Department, Independent Public Teaching Hospital No. 1, Lublin; Medical University, Lublin https://orcid.org/0000-0001-6970-1698

DOI:

https://doi.org/10.12775/JEHS.2020.10.08.029

Keywords

pregnancy-associated breast cancer, breast cancer, prognosis, pregnancy, breast cancer treatment

Abstract

Introduction: Pregnancy-associated breast cancer (PABC) is the most common malignancy in pregnant women with an incidence of 1 in 3-10 thousand pregnancies. It is mostly defined as breast cancer diagnosed during pregnancy or within 1 year postpartum. The number of PABCs is going to raise due to the trend of delaying childbearing. 

Purpose: This review summarizes data on the occurrence and characteristics of PABC. The analysis comprises diagnosis and proper treatment of BC during pregnancy. Prognosis of women and their offspring are emphasized. 

Material and methods: The review is based on publications mainly from 2010 to 2019 and 5 articles from 1994-2008 collected on the PubMed.  

Results: The sensitivity of breast ultrasonography (USG) in pregnancy is 70-100% and it is considered as safe for the fetus. Staging evaluation in pregnant women consists of chest x-ray, liver USG and non-contrast bone MRI. 71-88% of PABCs are invasive ductal carcinomas. Treatment consists of breast surgery regardless of time and optionally, chemotherapy from the 2nd trimester. Radiotherapy, tamoxifen and trastuzumab are contraindicated in PABC. Therapeutic abortion does not improve oncological outcome. Overall prognosis is similar for both pregnant and non-pregnant patients with similar type and stage of BC. The rate of congenital malformations is 1,3% for both children of PABC patients treated with chemotherapy and born from women without chemotherapeutic treatment. The most frequent obstetrical complication of PABC treatment is preterm delivery. 

Conclusions: Pregnancy does not impact oncologic outcome, if the treatment is appropriate. PABC patients have survival rates consistent with the stage of disease. Proper treatment of PABC does not increase the risk of congenital malformations and is relatively safe for the fetus.  

Author Biography

Bogumiła Ciseł, Oncological Surgery Department, Independent Public Teaching Hospital No. 1, Lublin; Medical University, Lublin

Assistant/MD, PhD (Department of Surgical Oncology)

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Published

2020-08-20

How to Cite

1.
ZIELIŃSKA, Martyna Maria, ZARANKIEWICZ, Natalia, KUCHNICKA, Aleksandra, KOSZ, Katarzyna & CISEŁ, Bogumiła. Pregnancy-associated breast cancer - diagnosis, treatment and outcomes for women and their offspring. Journal of Education, Health and Sport [online]. 20 August 2020, T. 10, nr 8, s. 251–259. [accessed 30.11.2021]. DOI 10.12775/JEHS.2020.10.08.029.

Issue

Vol. 10 No. 8 (2020)

Section

Review Articles

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The periodical offers access to content in the Open Access system under the Creative Commons non-exclusive license (CC BY-ND 4.0).

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