Endometriosis and ovarian cancer - what they have in common?
Keywordsendometriosis, ovarian cancer, ERONs
Introduction and purpose:
Endometriosis is one of the most common diseases among women in the reproductive age. Although its etiology remains not fully understood, several models of endometriosis development are taken into consideration. Many studies have been focused on hormonal and genetic alterations in endometriosis. The results of these studies allow for a thesis on common origin of endometriosis anda few types of ovarian cancer.
The aim of this review is to present actual knowledge about endometriosis’ development conditions and a possible association with ovarian cancer.
Material and method:
The review concerned articles published in years 2012-2020, which were collected in the PubMed and Google Scholar. Particular attention was paid to the development of both the endometriosis and Endometriosis-Related Ovarian Neoplasms (ERONs) and their genetic disorders.
Endometriosis development is connected with several risk factors and also immune, hormonal and genetic alterations. Some authors postulated that malignant transformation of endometriosis may be a multi-step process powered by increasing levels of estrogen. Many studies confirmed that mutations of ARID1A and PIK3CA genes are likely to be present in the majority of cases of ovarian cancer with adjacent endometriosis.
The awareness of clinical features and medical complications of endometriosis is spreading increasingly around the world. Many studies are focused on genetic causes of this illness. It may be supposed that we will be able to select women with endometriosis and increased risk of ovarian cancer and prevent its development.
Králíčková M, Losan P, Vetvicka V. Endometriosis and cancer. Womens Health (Lond). 2014; 10(6): 591-7. doi: 10.2217/whe.14.43.
Anglesio MS, Yong PJ. Endometriosis associated Ovarian Cancers. Clin Obstet Gynecol. 2017; 60(4): 711-727. doi: 10.1097/GRF.0000000000000320.
Garavaglia E, Sigismondi C, Ferrari S, Candiani M4. The origin of endometriosis-associated ovarian cancer from uterine neoplastic lesions. Med Hypotheses. 2018 ;110 :80-82. doi: 10.1016/j.mehy.2017.11.006
Pearce CL, Templeman C, Rossing MA, Lee A, Near AM, Webb PM, et al. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies. Lancet Oncol. 2012; 13(4): 385–394. doi: 10.1016/S1470-2045(11)70404-1
Anglesio MS,i Bashashati A, Wang YK, Senz J, Ha G, Yang W, et al. Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden. J Pathol. 2015; 236(2): 201–209. doi: 10.1002/path.4516
Mehedintu C, Plotogea MN, Ionescu S, Antonovici M. Endometriosis still a challenge. J Med Life. 2014; 7(3): 349–357
Yuan Z, Cragun J, Chambers S, Zheng W, Wang Y. Cell origin of endometriosis: contribution by the fallopian tube epithelium. Am J Clin Exp Obstet Gynecol. 2013; 1(1): 37-42 ISSN:2330-1899/AJCEOG1310002
Shafrir AL, Farland LV, Shah DK, Harris HR, Kvaskoff M, Zondervan K, et al. Risk for and consequences of endometriosis: A critical epidemiologic review. Best Pract Res Clin Obstet Gynaecol. 2018; 51:1-15. doi: 10.1016/j.bpobgyn.2018.06.001
Mori T, Ito F, Koshiba A, Kataoka H, Tanaka Y, Okimura H, et al. Aromatase as a target for treating endometriosis. J Obstet Gynaecol Res. 2018; 44(9): 1673-1681. doi: 10.1111/jog.13743.
Basta P, Koper K, Kazmierczak W, Wisniewski M, Makarewicz A, Dutsch-Wicherek M, et al. The biological role of Treg cells in ectopic endometrium homeostasis. Histol Histopathol. 2014; 29(10):1217-33. doi: 10.14670/HH-29.1217
Riccio LDGC, Santulli P, Marcellin L, Abrão MS, Batteux F, Chapron C. Immunology of endometriosis. Best Pract Res Clin Obstet Gynaecol. 2018; 50:39-49. doi: 10.1016/j.bpobgyn.2018.01.010
Gogacz M, Winkler I, Bojarska-Junak A, Tabarkiewicz J, Semczuk A, Rechberger T, et al. Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis. J Reprod Immunol. 2016; 117:39-44. doi: 10.1016/j.jri.2016.04.289
Izumi G, Koga K, Takamura M, Makabe T, Satake E, Takeuchi A, et al. Involvement of immune cells in the pathogenesis of endometriosis. J Obstet Gynaecol Res. 2018; 44(2):191-198. doi: 10.1111/jog.13559
Thiruchelvam U, Wingfield M, O'Farrelly C. Natural Killer Cells: Key Players in Endometriosis. Am J Reprod Immunol. 2015; 74(4):291-301. doi: 10.1111/aji.12408
Porpora MG, Scaramuzzino S, Sangiuliano C, Piacenti I, Bonanni V, Piccioni MG et al. High prevalence of autoimmune diseases in women with endometriosis: a case-control study. Gynecol Endocrinol. 2020 Apr;36(4):356-359. doi: 10.1080/09513590.2019.1655727
Sapkota Y, Steinthorsdottir V, Morris AP, Fassbender A, Rahmioglu N, De Vivo I, et al. Meta-analysis Identifies Five Novel Loci Associated With Endometriosis Highlighting Key Genes Involved in Hormone Metabolism. Nat Commun. 2017; 24;8:15539. doi: 10.1038/ncomms15539
Gilabert-Estelles J, Braza-Boils A, Ramon LA, Zorio E, Medina P, Espana F, et al. Role of microRNAs in gynecological pathology. Curr Med Chem. 2012; 19(15) :2406-13. doi: 10.2174/092986712800269362
Maeda D, Shih IeM. Pathogenesis and the role of ARID1A mutation in endometriosis-related ovarian neoplasms. Adv Anat Pathol. 2013; 20(1):45-52. doi: 10.1097/PAP.0b013e31827bc24d
Alcázar JL, Guerriero S, Ajossa S, Parodo G, Piras B, Peiretti M, et al. Extragenital endometrial stromal sarcoma arising in endometriosis. Gynecol Obstet Invest. 2012;73(4):265-71. doi: 10.1159/000336522.
Nezhat FR, Apostol R, Nezhat C, Pejovic T. New insights in the pathophysiology of ovarian cancer and implications for screening and prevention. Am J Obstet Gynecol. 2015; 213(3):262-7. doi: 10.1016/j.ajog.2015.03.044.
Ñiguez Sevilla I, Machado Linde F, Marín Sánchez MDP, Arense JJ, Torroba A, Nieto Díaz A, et al. Prognostic importance of atypical endometriosis with architectural hyperplasia versus cytologic atypia in endometriosis-associated ovarian cancer. J Gynecol Oncol. 2019; 30(4): e63. doi: 10.3802/jgo.2019.30.e63
Mangili G, Bergamini A, Taccagni G, Gentile C,
Panina P, Viganò P, et al. Unraveling the two entities of endometrioid ovarian cancer: a single center clinical experience. Gynecol Oncol. 2012; 126(3): 403-7. doi: 10.1016/j.ygyno.2012.05.007
Falconer H, Sundqvist J, Xu H, Vodolazkaia A, Fassbender A, Kyama C, et al. Analysis of common variations in tumor-suppressor genes on chr1p36 among Caucasian women with endometriosis. Gynecol Oncol. 2012; 127(2): 398-402. doi: 10.1016/j.ygyno.2012.08.013
Munksgaard PS, Blaakaer J.The association between endometriosis and ovarian cancer: a review of histological, genetic and molecular alterations. Gynecol Oncol. 2012 Jan;124(1):164-9. doi: 10.1016/j.ygyno.2011.10.001.
Wang S, Qiu L, Lang JH, et al. Prognostic analysis of endometrioid epithelial ovarian cancer with or without endometriosis: a 12-year cohort study of Chinese patients. Am J Obstet Gynecol 2013 ;209: 241.e1-9 doi: 10.1016/j.ajog.2013.05.032
Vercellini P, Viganò P, Buggio L, Makieva S, Scarfone G, Cribiù FM, et al. Perimenopausal management of ovarian endometriosis and associated cancer risk: When is medical or surgical treatment indicated? Best Pract Res Clin Obstet Gynaecol. 2018; 51:151-168. doi: 10.1016/j.bpobgyn.2018.01.017
Wang C, Liang Z, Liu X, Zhang Q, Li S. The Association between Endometriosis, Tubal Ligation, Hysterectomy and Epithelial Ovarian Cancer: Meta-Analyses.Int J Environ Res Public Health. 2016; 14;13(11)
Kvaskoff M, Horne AW, Missmer SA. Informing women with endometriosis about ovarian cancer risk. Lancet. 2017 Dec 2;390(10111):2433-2434. doi: 10.1016/S0140-6736(17)33049-0.
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