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Journal of Education, Health and Sport

Characteristic of warfarin
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Characteristic of warfarin

Authors

  • Marzena Teresa Baran Chair and Department of Biochemistry and Molecular Biology, Medical University of Lublin
  • Paulina Miziak Chair and Department of Biochemistry and Molecular Biology, Medical University of Lublin
  • Katarzyna Bonio Department of Cell Biology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Lublin

DOI:

https://doi.org/10.12775/JEHS.2020.10.08.009

Keywords

warfarin, cumarine, vitamin K antagonist, medicine, anticoagulants

Abstract

In modern pharmacology, compounds of natural origin are gaining more and more recognition. One of them is warfarin, which is a compound of organic coumarin derivatives. It is used medicinally in the anticoagulant doctor. This compound was commercially introduced to the United States in the 1950s. It has been available on the Polish market since 2006. Warfarin is an antagonist of vitamin K. It works by inhibiting the synthesis of vitamin K in the liver and thus blocking the synthesis of vitamin K dependent blood clotting factors (II, VII, IX, X). It is widely used by people suffering from cardiovascular diseases such as venous thrombosis and venous embolism. Adopted by patients with suspected or after a heart attack. Despite its undisputed positive effect, one should remember about the numerous side effects resulting from long-term use of warfarin. They may be due to intolerance to this compound, which causes nausea, vomiting, and allergic reactions. Moreover, recent studies show that it may have a destructive effect on the liver and cause calcification of blood vessels. Keep in mind that warfarin can interact with many substances you are taking for other medical conditions. Agents that increase the effects of warfarin include antibiotics such as erythromycin, deoxicillin, commonly used drugs containing caffeine, acetylsalicylic acid and naturally derived compounds found in ginkgo, garlic and sage. Compounds that weaken the effect of warfarin are barbiturates, cyclosporine, vitamin C, and St. John's wort.

References

Poterucha T.J. i Goldhaber S.Z., Warfarin and Vascular Calcification, American Journal of Medicine, 2016, Vol 129, Issue 6

Nataša Milić i inni, Warfarin Interactions with Medicinal Herbs, Natural Product Communications, 2014, vol. 9, no. 8

Leite P.M. i inni, Review on mechanisms and interactions in concomitant use of herbs and warfarin therapy, Biomedicine and Pharmacotherapy, 2016, vol. 83

Sidłowska E. i Kozłowski D., Clinical use of warfarin in the cardiology, G E R I A T R I A, 2008, 2

Tales J.S. I inni, Warfarin: pharmacological profile and drug interactions with antidepressants Einstein (São Paulo), 2012, vol.10 no.1

European Journal of Cardiovascular Prevention and Rehabilitation 2007; 14(suppl 2): 86-87.

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Published

2020-08-01

How to Cite

1.
BARAN, Marzena Teresa, MIZIAK, Paulina and BONIO, Katarzyna. Characteristic of warfarin. Journal of Education, Health and Sport. Online. 1 August 2020. Vol. 10, no. 8, pp. 78-80. [Accessed 3 July 2025]. DOI 10.12775/JEHS.2020.10.08.009.
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Issue

Vol. 10 No. 8 (2020)

Section

Review Articles

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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