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Journal of Education, Health and Sport

Pathological changes in mucous membrane and microcirculatory bed vessels of rats oral cavity at modeling of diabetes mellitus
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Pathological changes in mucous membrane and microcirculatory bed vessels of rats oral cavity at modeling of diabetes mellitus

Authors

  • P. D. Rozhko Odessa National Medical University
  • V. V. Gargin Kharkov National Medical University

DOI:

https://doi.org/10.12775/JEHS.2020.10.07.045

Keywords

experimental animal, oral mucosal membrane, microcirculatory bed vessels

Abstract

At experimental modeling of diabetes mellitus type II in rats, ischemic and dystrophic processes develop in periodontal tissues. It leads to emergence of destructive-inflammatory processes in animals and one of their pathogenic factors is apoptosis activation and compensatory activation of angiogenesis as evidenced by 1.81 times increase of monoclone BAX and 2.89 times increase of VEGF. The pathological processes mentioned should be taken into account in the development of therapeutic and prophylactic complexes of accompanying orthopedic treatment for diabetes mellitus patients. 

References

Tovmasyan A.M., Panin A. M., Mkrtumyan A. M., Kozlova M. V. The use of dental implants in patients with type 2 diabetes mellitus and osteopenic syndrome. Saratovskiy nauchno-meditsinskiy zhurnal. 2009;5(2):242-244.

Kuznetsov S.V. Dental'naya implantatsiya u patsientov s somaticheskoy patologiey [Dental implantation in patients with somatic pathology]: Abstract of a candidate's thesis of medical sciences. Moscow, 2009, 27 p.

Reva G. V., Tolmachov V. Ye., Kalinin I. O. [et al.] Morphology of the oral mucosa in the dynamics of dental implantation in patients with type 2 diabetes mellitus. Sovremennyye problemy nauki i obrazovaniya. 2018;1:60-71.

Zagorskiy V. A. Morfologiya kostnoy tkani pri dental'noy implantatsii [Morphology of bone tissue during dental implantation]. Metodicheskiye rekomendatsii. Moscow: Libri Plyus Publ., 2017. 21p.

Ivashchenko A. V., Markov I. I., Il'in A. N. Morphological aspects of dental implantation (literature review). Morfologicheskiye vedomosti. 2007;3-4:186-189.

Nikitin V. S., Kapitonova O. P., Antonova I. N. Features of dental implantation in patients with diabetes. Translyatsionnaya meditsina. 2015;6:25-31.

Sarkisov D.S., Perov YU. L. Mikroskopicheskaya tekhnika: Rukovodstvo [Microscopic technique: Manual]. Moscow: Meditsina Publ., 1996. 544 p.

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Published

2020-07-31

How to Cite

1.
ROZHKO, P. D. and GARGIN, V. V. Pathological changes in mucous membrane and microcirculatory bed vessels of rats oral cavity at modeling of diabetes mellitus. Journal of Education, Health and Sport. Online. 31 July 2020. Vol. 10, no. 7, pp. 438-444. [Accessed 3 July 2025]. DOI 10.12775/JEHS.2020.10.07.045.
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Issue

Vol. 10 No. 7 (2020)

Section

Research Articles

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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