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Journal of Education, Health and Sport

A comparative study on the effectiveness of application of different types of biological matrixes on mandibular alveolar mucosa lesion healing
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A comparative study on the effectiveness of application of different types of biological matrixes on mandibular alveolar mucosa lesion healing

Authors

  • H. O. Vyshnevska SI “Institute of Dentistry and Maxillofacial Surgery of the National Academy of Medical Sciences of Ukraine”
  • Z. Sh. Kakabadze Tbilisi State Medical University
  • S. A. Schnayder SI “Institute of Dentistry and Maxillofacial Surgery of the National Academy of Medical Sciences of Ukraine”
  • L. M. Zayats Ivano-Frankivsk National Medical University
  • O. I. Tiron Odessa National Medical University
  • R. S. Vastyanov Odessa National Medical University

DOI:

https://doi.org/10.12775/JEHS.2020.10.06.040

Keywords

amniotic membrane, PRP growth factors, hyaluronic acid, epithelization, wound healing

Abstract

Periodontal diseases is one of the most relevant and important problem in modern dentistry due to their increasing prevalence in population, association with the occurrence of focus of chronic infection, progressive development and irreversibility which, in case of severe damage of periodontal tissues, eventually leads to a loss of the number of teeth. All of the named factors eventually lead to the development of irreversible inflammatory-dystrophic and destructive changes in periodontal tissues. During the recent years the method of guided tissue regeneration that uses membranes is being successfully used for the treatment of periodontal diseases.

A comparative study on the mandibular alveolar mucosa lesion healing during application of different types of biological matrixes containing decellularized amniotic membrane, decellularized amniotic membrane in combination with platelet-rich plasma (PRP) growth factors, and decellularized amniotic membrane in combination with PRP growth factors and hyaluronic acid was performed. The study proved the acceleration of the processes of wound area reduction. Under experimental conditions, the wound healing lasted from day 3 to day 5 of the study; however, the rate of reduction of the wound area was slower, which indicates an alterative stage of the acute inflammatory process. During days 5 – 7 (stage of regeneration, the 2nd phase of wound process) the wound area reduced rapidly and by day14 a complete epithelization of the surgical wound was observed in all groups using decellularized amniotic membrane. In the group using the combination of PRP growth factors and hyaluronic acid the epithelization of wound was already observed on the day5. In the control group healing occurres with scar formation.

References

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Published

2020-06-30

How to Cite

1.
VYSHNEVSKA, H. O., KAKABADZE, Z. Sh., SCHNAYDER, S. A., ZAYATS, L. M., TIRON, O. I. and VASTYANOV, R. S. A comparative study on the effectiveness of application of different types of biological matrixes on mandibular alveolar mucosa lesion healing. Journal of Education, Health and Sport. Online. 30 June 2020. Vol. 10, no. 6, pp. 382-393. [Accessed 22 May 2025]. DOI 10.12775/JEHS.2020.10.06.040.
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Vol. 10 No. 6 (2020)

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Research Articles

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