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Journal of Education, Health and Sport

Vitamine D supply in girls of puberty age with autoimmune hepatitis
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Vitamine D supply in girls of puberty age with autoimmune hepatitis

Authors

  • E. F. Сhaykivska Danylo Halytsky Lviv National Medical University
  • V. S. Berezenko SI "Institute of Pediatrics, Obstetrics and Gynecology named Academic Elena M. Lukyanova National Academy of Medical Sciences of Ukraine”
  • T. F. Tatarchuk SI "Institute of Pediatrics, Obstetrics and Gynecology named Academic Elena M. Lukyanova National Academy of Medical Sciences of Ukraine”

DOI:

https://doi.org/10.12775/JEHS.2020.10.05.039

Keywords

girls, puberty age, autoimmune hepatitis, vitamin D supply

Abstract

Vitamin D undergoes important biotransformation and inactivation in the liver. Because vitamin D is metabolized in the liver, abnormal vitamin D metabolism can be expected to be associated with chronic liver disease, including autoimmune hepatitis (AIH). The prevalence of vitamin D deficiency in puberty was the justification for the objective of the study– to determine the characteristics of vitamin D supply in girls of puberty age with AIH with autoimmune hepatitis during this period. Materials and methods. To solve this goal, a comprehensive clinical and paraclinical examination of 66 girls withAIH and 180 relatively healthy girls of the control group aged 12-17 years. The complex included clinical and anamnestic data, biochemical study of liver function, determination of serum autoantibodies and markers of viral hepatitis, the level of 25- (OH) D in blood serum, ultrasound and elastography of the hepatobiliary system organs, liver biopsy. Results. The mean level of vitamin 25 (OH) D in the serum of girls with AIH of pubertal age was 17.14 ± 1.06 vs. 23.27 ± 0.53 ng / ml in the control (p<0,01). In 66.67% of patients with AIH there was a deficiency of 25 (OH) D, in 22.73% – insufficiency, in 10.61% – the optimal level. The supply of vitamin D depended on the histological activity of AIG. Among girls with AIH and histological activity index> 9 points, the share of patients with vitamin D deficiency was 79.41% compared with 53.13% of cases among girls with AIH, where the histological activity index was <9 points (χ2=5.13; p<0,02). Conclusions. Cytolysis, cholestasis, mesenchymal-inflammatory syndrome, hepatocellular insufficiency in AIH in girls of puberty agedevelops against the background of reduced vitamin D supply, which depends on the histological activity of the disease.

References

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Published

2020-05-29

How to Cite

1.
Сhaykivska E. F., BEREZENKO, V. S. and TATARCHUK, T. F. Vitamine D supply in girls of puberty age with autoimmune hepatitis. Journal of Education, Health and Sport. Online. 29 May 2020. Vol. 10, no. 5, pp. 366-379. [Accessed 27 September 2023]. DOI 10.12775/JEHS.2020.10.05.039.
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Vol. 10 No. 5 (2020)

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Research Articles

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