The overall structure of microbiota in patients with adenocarcinoma stomach and colon cancer
Keywordsmicrobiota, tumor tissue activation, colorectal carcinoma and stomach cancer, biogenic amines, Streptococcus Bovis
Accumulating evidence suggests that the human bowel microbiota contributes to the etiology of colorectal cancer (CRC) and stomach cancer, not only via the pro-carcinogenic activities of specific pathogens but also via the influence of the wider microbial community, particularly its metabolome.
The aim of the study
The aim of this study was to analyzes the overall structure of microbiota in patients with adenocarcinoma of colorectal and the stomach and healthy controls.
The studies suggested that colorectal cancer and stomach cancer develops from the complex interactions between inherited susceptibility and environmental factors, there a strong association between adenomatous polyps and some pathogenic bacteria are the precursors of the vast majority of colorectal cancers and stomach. Thus, the data suggested the development of intestinal dysbiosis in patients with adenocarcinoma, which was characterized by inhibiting obligate protective microflora and activation opportunistic microorganisms on the base of carbohydrates, fats, and proteins metabolism disturbances and accumulation of toxic metabolic products that may be an important pathogenetic factor of tumor tissue activation, induction, proliferation, and metaplasia. Significant accumulation of biogenic amines (methylamine, serotonin, histamine) is a leading metabolic profile of microflora inpatient with adenocarcinoma and may have a predictive value for diagnosis, pathogenetic therapy, and determination of food nutrients role in the mechanisms of cancer formation, as well as identifying populations of cancer risk.
The composition of the tumor microbiome differed from that of adjacent non-neoplastic tissue. The subsite-specific alterations in the colorectal carcinoma and stomach cancer microbiota. There is a high incidence of colorectal cancer and stomach cancer associated with Streptococcus Bovis. These results suggested that the mucosa-associated microbiota is dynamically associated with colorectal carcinoma, which may provide evidence for microbiota-associated diagnostic, prognostic, preventive, and therapeutic strategies for colorectal carcinoma and stomach cancer.
Atkins D., Eccles M., Flottorp S.Systems for grading the quality of evidence and the strength of recommendations I: a critical appraisal of existing approaches. The GRADE Working Group. BMC Health Serv Res. - 2004. – T1. – P:34-38.
AGREE on Collaboration. Development and validation of an international appraisal instrument for assessing the quality of clinical practice guidelines: the AGREE project. Qual Saf Health Care. - 2003. – T.12. - P: 18-23.
Bray F., Ferlay J., Soerjomataram I. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. – 2018. – T. 68. - P: 393-424.
Carneiro F., Machado J.C., David L. Current thoughts on the histopathogenesis of gastric cancer. Eur J Cancer Prev – 2001. – T.10. - P:101-102.
Correa P. Human gastric carcinogenesis: a multistep and multifactorial process – First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. - 1992. – T. 52. - P: 6735-6740.
Ferreira R.M., Pereira-Marques J., Pinto-Ribeiro I., et al. Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota. Journal Gut. – 2017. – T.67. – P:226–236. doi: 10.1136/gutjnl-2017-314205.
Fukao A., Hisamichi S., Ohsato N. Correlation between the prevalence of gastritis and gastric cancer in Japan. Cancer Causes Control. – 1993. – T.4. - P: 17-20.
Genta R.M. Gastric atrophy and atrophic gastritis – nebulous concepts in search of a definition. Aliment Pharmacol Ther. – 1998. – T.12. - P: 17-23.
Guyatt GH, Oxman AD, Vist GE. et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. - 2008. – T.336. - P: 924-926.
Kapadia C.R. Gastric atrophy, metaplasia, and dysplasia: a clinical perspective. J Clin Gastroenterol. – 2003. – T.36. - P: S29-36.
Laurèn P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand. – 1965. – T.64. - P: 31-49.
Lin X.H., Huang K.H., Chuang W.H., et al. The long term effect of metabolic profile and microbiota status in early gastric cancer patients after subtotal gastrectomy. PLoS One. – 2018. – T.13. – P:e0206930. doi: 10.1371/journal.pone.0206930.
Mera R.M., Bravo L.E., Camargo M.C. Dynamics of Helicobacter pylori. Gut. – 2018. – T.67. - P: 1239-1246. Epub 2017 Jun 24.
Rogers M.B., Aveson V., Firek B., et al. Disturbances of the perioperative microbiome across multiple body sites in patients undergoing pancreaticoduodenectomy. Journal Pancreas. - 2016. – T.46. - P:260–267. doi: 10.1097/MPA.0000000000000726.
Sohn S.H., Kim N., Jo H.J., et al. Analysis of gastric body microbiota by pyrosequencing: possible role of bacteria other than Helicobacter pylori in the gastric carcinogenesis. J Cancer Prev. – 2017. – T.22. - P:115–125. doi: 10.15430/JCP.2017.22.2.115.
Weiren Liang, Yan Yang, Haiyong Wang, Haohao Wang, Xiongfei Yu. Gut microbiota shifts in patients with gastric cancer in the perioperative period/ Medicine (Baltimore). – 2019. - T 98(35). P: 1 – 6. e16626. doi: 10.1097/MD.0000000000016626.
Yue H., Shan L., Bin L. The significance of OLGA and OLGIM staging systems in the risk assessment of gastric cancer: a systematic review and meta-analysis. Gastric Cancer. – 2018. – T. 21. - P: 579-587. Epub 2018 Feb 19.
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