Laboratory-biochemical features of the course of chronic hepatitis C with polymorphism rs11536889 + 3725G/C of TLR-4 gene
KeywordsHCV, chronic hepatitis C, cytolysis, cholestasis, hepatocellular insufficiency, TLR-4
Chronic HCV infection remains as a global health problem due to its wide prevalence, latent course without clinical manifestations, development of liver fibrosis with the eventual formation of cirrhosis and liver cancer, which largely leads to poor prognosis and short survival of patients. Therefore, it is necessary to study in more detail the risk factors for adverse events, as their modification which may improve the prognosis and clinical consequences for patients with CHC. The article considers the changes of the main biochemical markers of liver damage and their dependence with the rs11536889 + 3725G/C polymorphism of the TLR-4 gene.
Alhmada, Y., Selimovic, D., Murad, F., Hassan, S. L., Haikel, Y., Megahed, M., ... & Hassan, M. (2017). Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies. World journal of gastroenterology, 23(5), 743.
Amjad, M., Moudgal, V., & Faisal, M. (2013). Laboratory methods for diagnosis and management of hepatitis C virus infection. Laboratory Medicine, 44(4), 292-299.
Chigbu, D. I., Loonawat, R., Sehgal, M., Patel, D., & Jain, P. (2019). Hepatitis C Virus infection: Host–virus interaction and mechanisms of viral persistence. Cells, 8(4), 376.
Missiha, S. B., Ostrowski, M., & Heathcote, E. J. (2008). Disease progression in chronic hepatitis C: modifiable and nonmodifiable factors. Gastroenterology, 134(6), 1699-1714.
Patra, T., Ray, R. B., & Ray, R. (2019). Strategies to circumvent host innate immune response by hepatitis C virus. Cells, 8(3), 274.
Viso, A. T. R. (2007). Pathogenesis of hepatitis C: HCV consensus 2007. Brazilian Journal of Infectious Diseases, 11, 14-19.
Xu, R., Zhang, Z., & Wang, F. S. (2012). Liver fibrosis: mechanisms of immune-mediated liver injury. Cellular & molecular immunology, 9(4), 296-301.
Bilalova, A.R., & Makashova, V.V. (2015). Clinical and laboratory characteristics of chronic hepatitis and liver cirrhosis of various etiology. Archive of Internal Medicine, (2). (in Russian)
Gavrilyuk, A. O. (2015). Laboratory and biochemical parameters in patients with viral hepatitis c, b and c + b after five years of antiviral therapy. The world of medicine and biology, 11(4-1 (53)). (in Ukrainian)
Dontsov, D.V., Ambalov, Yu.M., & Vasilieva, V.V. (2011). Assessment of the degree of activity of chronic hepatitis C. Modern problems of science and education, (6), 6-6. (in Russian)
Moroz, LV, & Bondaruk, I. Yu. (2019). Diagnostic role of non-invasive markers of liver fibrosis in patients with chronic viral hepatitis C. Hepatology, (2), 28-34. (in Ukrainian)
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