Current review of conections between lichen planus and mental disorders
Keywordslichen planus, mental disorders, etiopatogenesis, stress
AbstractThe major aim of this article was to examine causal connection or temporal relation between mental disorders and lichen planus (LP). LP is a chronic, inflammatory skin condition affecting less than 1% of the adult population. It is observed in many different clinical forms, some affecting more psychical state than others. Indeed, connection exist between LP and mental state. LP as an autoimmune disease can also be aggravated by psychosocial stressors. Etiopatogenesis of LP is idiopathic and involves immunologic components. Main pathogenetic mechanism of LP include increased apoptosis of keratinocytes and decreased apoptosis of T-cells. Many authors report relationship LP between mental illness like depression and anxiety disorder or lack of emotional stability. One of the main symptoms of LP is is severe itch (present in 74 from 78 patients), which can be induced by stress.
Wagner G, Rose C, Sachse MM. Clinical variants of lichen planus. J Dtsch Dermatol Ges 2013; 11: 309-319.
Lauritano D et al. Oral lichen planus clinical characteristics in Italian patients: a retrospective analysis. Head & face medicine.2016; 12(1): 18. doi: 10.1186/s13005-016-0115-z.
Krasowska D. Lichen planus. Nowa Medycyna. 2000; 7(11): 21-24.
Weston G, Payette M. Update on lichen planus and its clinical variants. Int J Womens Dermatol. 2015; 1(3): 140–149. doi: 10.1016/j.ijwd.2015.04.001.
Heath L, Matin R. Lichen planus. InnovAiT: Education and Inspiration for General Practice. 2017; 10(3): 133–138. doi: 10.1177/1755738016686804.
Le Cleach L, Chosidow O, Lichen planus. N Eng J med 2012; 366: 723-32.
Krupaa, R Jayasri et al. Oral lichen planus: An overview. Journal of pharmacy & bioallied sciences. 2015; 7, Suppl 1: 158-61. doi: 10.4103/0975-7406.155873.
Tandon YK, Somani N, Cevasco NC, Bergfeld WF. A histologic review of 27 patients with lichen planopilaris. J Am Acad Dermatol 2008; 59(1): 91–8.
Lanfranchi-Tizeira HE, Aguas SC, Sano SM. Malignant transformation of atypical oral lichen planus: a review of 32 cases. Med Oral. 2003; 8: 2-9.
Giuliani M, Troiano G, Cordaro M, et al. Rate of malignant transformation of oral lichen planus: a systematic review. Oral Dis. 2019; 25(3): 693-709.
Tampa, Mircea et al. Markers of Oral Lichen Planus Malignant Transformation. Disease markers vol. 2018; 1959506. doi: 10.1155/2018/1959506.
Petruzzi M, De Benedittis M, Pastore L, Grassi FR, Serpico R. Peno-gingival lichen planus. J Periodontol. 2005; 76(12): 2293–8. doi: 10.1902/jop.2005.76.12.2293.
Adamczyk M, Młynarski T, Sierocińska-Sawa J, et al. Vulvo-vaginal-gingival syndrome – a case report. Dermatology Review. 2014; 101(4): 299-303. doi:10.5114/dr.2014.45124.
Arndt KA. Lichen planus. In: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF (eds): Dermatology in General Medicine. New York: Mc-Graw-Hill, 1993: 1134–43.
Li K, Mu ZL, Chen X, Wen GD, Zhao Y, Zhang JZ. Atopic Dermatitis-like Graft-versus-host Disease and Lichen Planus-like Graft-versus-host Disease: Alterations in Skin Barrier Function and Related Molecules. Chin Med J (Engl). 2017; 130(12): 1459–1466. doi: 10.4103/0366-6999.207475.
Georgescu SR, Tampa M, Mitran MI, et al. Potential pathogenic mechanisms involved in the association between lichen planus and hepatitis C virus infection. Exp Ther Med. 2019; 17(2): 1045–1051. doi: 10.3892/etm.2018.6987.
Mozaffari HR, Sharifi R, Sadeghi M. Prevalence of oral lichen planus in diabetes mellitus: A meta-analysis study. Acta Inform Med 2016; 24: 390-3.
Karthikeyan P, Aswath N. Stress as an etiologic co-factor in recurrent aphthous ulcers and oral lichen planus, Journal of Oral Science, 2016; 58 (2): 237-240.
Hashemy S, Gharaei S, Vasigh S, Kargozar S, Alirezaei B, Jahed Keyhani F, Amirchaghmaghi M. Oxidative stress factors and C‐reactive protein in patients with oral lichen planus before and 2 weeks after treatment. J Oral Pathol Med. 2016; 45: 35–40.
Kurago Zoya B. Etiology and pathogenesis of oral lichen planus: an overview. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2016; 122(1): 72-80.
Gorouhi F, Davari P, Fazel N. Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis. Scientific World Journal. 2014; 742826. doi: 10.1155/2014/742826.
Sawant N, Vanjari N, Khopkar U, Adulkar S. A Study of Depression and Quality of Life in Patients of Lichen Planus. The Scientific World Journal. 2015. 817481. doi: 10.1155/2015/817481.
Radwan-Oczko M et al. Psychopathological profile and quality of life of patients with oral lichen planus. Journal of applied oral science. 2017. 26..
Alrashdan M. Psychological factors in oral mucosal and orofacial pain conditions. Eur J Dent. 2017; 11(4): 548–552,
Guo YS et al. Analysis of type C behavior in patients with oral lichen planus. Journal of Peking University. Health Sciences, 2017; 49(1): 120-124.
Tadakamadla et al. Qualitative analysis of the impact of Oral Potentially Malignant Disorders on daily life activities. PLOS ONE. 2017; 12(4).
Welz-Kubiak K, Reich A, Szepietowski J. Clinical Aspects of Itch in Lichen Planus. Acta Dermato-Venereologica, 2017; 97(4): 505-508.
Mehdipour M et al. The Relationship between Anger Expression and Its Indices. Chonnam Medical Journal. 2019; 52: 112-116.
Pokupec et al. Lichen Ruber Planus As a Psychiatric Problem. Psychiatria Danubina; 2009; 21(4): 514-516.
Radwan-Oczko M et al. Psychopathological profile and quality of life of patients with oral lichen planus. Journal of Applied Oral Science. 2018; 26: e20170146. doi: 10.1590/1678-7757-2017-0146.
Adamo D, Ruoppo E, Leuci S, Aria M, Amato M, Mignogna M. Sleep disturbances, anxiety and depression in patients with oral lichen planus: A case‐control study. Journal of the European Academy of Dermatology and Venereology. 2015; 29(2): 291–297.
How to Cite
LicenseThe periodical offers access to content in the Open Access system under the Creative Commons non-exclusive license (CC BY-ND 4.0).
Number of views and downloads: 5
Number of citations: 0