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Journal of Education, Health and Sport

Substance P blockade effects on bone marrow hematopoiesis in secondary chronic inflammation
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  • Substance P blockade effects on bone marrow hematopoiesis in secondary chronic inflammation
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Substance P blockade effects on bone marrow hematopoiesis in secondary chronic inflammation

Authors

  • O. M. Shevchenko Kharkiv National Medical University
  • V. O. Sych Kharkiv National Medical University

DOI:

https://doi.org/10.12775/JEHS.2020.10.02.040

Keywords

red bone marrow, rats, experiment, inflammation, substance P

Abstract

Inflammation is defined by the features of bone marrow hematopoiesis. Thus, an objective of the study was to determine the substance P inhibition effects on bone marrow hematopoiesis in secondary chronic carrageenan-induced inflammation in experimental prospective controlled study on 132 white male WAG rats. On the background of blockade of substance P, the course of inflammation was characterized by a less intense neutrophilic reaction and the development of the lymphocyte component at earlier stages of inflammation. Given the peculiarities of bone marrow hematopoiesis in carrageenan secondary chronic inflammation on the background of its suppression, the influence of substance P on the course of chronic inflammation is certain.

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Published

2020-02-28

How to Cite

1.
SHEVCHENKO, O. M. and SYCH, V. O. Substance P blockade effects on bone marrow hematopoiesis in secondary chronic inflammation. Journal of Education, Health and Sport. Online. 28 February 2020. Vol. 10, no. 2, pp. 353-367. [Accessed 5 July 2025]. DOI 10.12775/JEHS.2020.10.02.040.
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Vol. 10 No. 2 (2020)

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Research Articles

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