Metabolic predictors of individual immune responses to adaptogenic balneotherapy
KeywordsElectrolytes, Nitrous and Lipoproteins parameters, Cholekinetics, Immunity.
Background. Earlier four variants of the immune responses to adaptogenic balneotherapy have been identified. All four variants of immune responses are virtually unmistakably (with an accuracy of 97,7%) predicted by a set of 20 predictors including 12 immune blood parameters and one saliva parameter, 4 information parameters, 2 fecal microbiota parameters as well as erythrocyturia. In the next study discriminant analysis revealed that constellation 8 HRV and 5 Endocrine parameters as well as Gender of the patient predicts the nature of the immune response with an accuracy of 90,9%. The purpose of this study is to search for predictors of immune responses among the registered Metabolic parameters. Material and methods. Theobjectofobservationwere 34menand 10 womenaged24-70yearsold,whocametotheTruskavets’ spa for the treatment of chronic pyelonephritis combined withcholecystitis inremission. We determined them theElectrokinetic index, Lipoproteines spectrum, plasma and daily urine levels of Electrolytes and Nitrous metabolites as well as basal and postprandial volume of gall-bladder. Results. Discriminant analysisrevealed 16 parameters as the predictors. Of these, 3 reflect the level of Plasma Electrolytes, 5 - the Urine Electrolytes, another 2 - the levels of plasma and urine Urea. Other predictors were: Very Low Density Lipoprotein Cholesterol plasma level, Body Mass index, fasting gallbladder volume and 30 minutes after cholekinetics, Electrokinetic index, and patient Age. These predictors, taken together, determine the nature of the immune response with an accuracy of 95,5%. Conclusion. The variety of immune responses to adaptogenic balneotherapy is quite strictly conditioned by the initial state of the neuroendocrine-immune complex, microbiota, cholekinetics and metabolism, as well as the age and sex of patients.
Goryachkovskiy АМ. Clinical Biochemistry [in Russian]. Odesa: Astroprint; 1998: 608 p.
Gozhenko AI. Functional-metabolic continuum [in Russian]. J NAMS of Ukraine. 2016; 22(1): 3-8.
Gozhenko AI, Zukow W, Polovynko IS, Zajats LM, Yanchij RI, Portnichenko VI, Popovych IL. Individual Immune Responses to Chronic Stress and their Neuro-Endocrine Accompaniment. RSW. UMK. Radom. Torun; 2019: 200 p.
Hiller G. Test for the quantitative determination of HDL cholesterol in EDTA plasma with Reflotron®. Klin Chem. 1987; 33: 895-898.
Klecka WR. Discriminant Analysis [trans. from English to Russian] (Seventh Printing, 1986). In: Factor, Discriminant and Cluster Analysis. Moskva: Finansy i Statistika; 1989: 78-138.
Kyrylenko IG. Changes in electrokinetic index of buccal epithelium correlated with changes in some parameters of EEG, HRV, hemodynamics and metabolism. Experimental and Clinical Physiology and Biochemistry. 2018; 2(82): 5-14.
Kyrylenko IG, Fajda OI, Drach OV, Popel SL, Popel RL, Zukow W. Relationships between electrokinetic index of buccal epithelium and some functional and metabolic parameters at men with chronic pyelonephrite. Journal of Education, Health and Sport. 2016; 6(1): 302-314.
Kyrylenko IG, Flyunt I-SS, Fil’ VM, Zukow W, Popovych IL. Changes in electrokinetic index of buccal epithelium correlated with changes in some parameters of immunity and fecal microbiocenosis. Journal of Education, Health and Sport. 2018; 8(10): 168-170.
Marfiyan OM, Korolyshyn TA, Barylyak LG, Kovbasnyuk MM, Yavors’kyi OV, Zukow W, Popovych IL. Neuroendocrine-immune and metabolic accompaniments of cholecystokinetic effects of balneotherapy on spa Truskavets’. Journal of Education, Health and Sport. 2015; 5(5): 21-30.
Mel’nyk OI, Struk ZD. Predictors of individual immune responses to adaptogens. Experimental and Clinical Physiology and Biochemistry. 2019; 88(4): 5-15.
Pat. 28113, Ukraine, NSI A61V10/00. Method of rapid testing efficiency rehabilitation of health. Shakhbazov VG, Kolupaeva TV, Shuvalov IM et al. 2000; Bul №5.
Shkorbatov YuG, Kolupayeva TV, Shakhbazov VG, Pustovoit PA. On the relationship between electrokinetic properties of human nucleated cells with some physiological parameters [in Russian]. Fiziologiya Cheloveka. 1995; 21(2): 25-27.
Struk ZD, Mel’nyk OI, Zukow W, Popovych IL. The diversity of immune reactions to balneotherapy and their accompaniments. Journal of Education, Health and Sport. 2019; 9(11): 349-373.
Struk ZD, Mel’nyk OI, Zukow W, Popovych IL. Vegetative and endocrine predictors of individual immune responses to adaptogenic balneotherapy. Journal of Education, Health and Sport. 2020; 10(1): 218-225.
Struk ZD, Mel’nyk OI, Mysakovets’ OG. Individual immune responses to adaptogens and their predictors. In: Rehabilitation Medicine and Health-Resort Institutions Development. Proceedings of the 19th International Applied Research Conference (Kyїv, 11-12 December 2019). Edited by O. Gozhenko, W. Zukow. Toruń, Kyiv. 2019: 83-84.
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