Evaluation of the influence of thiotriazoline on the cytokine status disturbances in the blood serum under the condition of experimental contact dermatitis and experimental pneumonia
Keywordscontact dermatitis, pneumonia, cytokines, thiotriazoline
The aim of our research was to determine the character of the disturbances content level of pro-inflammatory interleukin-6, tumor necrosis factor-α and anti-inflammatory cytokine interleukin-10 (IL-10) in the serum of guinea pigs and estimation of thiotriazoline influence on the cytokine profile in the conditions of formation of combined pathology - experimental contact dermatitis and experimental pneumonia.
It has been determined significant advantage of pro-inflammatory cytokine activity, which increasing according the development of the combined pathological process and, simultaneously, reducing the anti-inflammatory IL-10. It has been detected corrective action of thiotriazoline on the investigated indices of cytokine profile.
Mikhailovskaya N. S., Kulinich T. A., Kulinich A. V. The impact of the migrated community-acquired pneumonia on the development of kardiovaskularnih complications in patients with ischemic heart disease. Achievements of clinical and experimental medicine. 2014. No. 2. P. 12-16.
Moudgil KD, Choubey D. Cytokines in autoimmunity: role in induction, regulation, and treatment. J Interferon Cytokine Res. 2011 Oct;31(10):695-703. doi: 10.1089/jir.2011.0065. Epub 2011 Sep 23.
Palomo J, Dietrich D, Martin P, Palmer G, Gabay C. The interleukin (IL)-1 cytokine family—balance between agonists and antagonists in inflammatory diseases. Cytokine 2015;6:25-37.
Volkova V.A., Kuchynska I.V., Tiupka T.I. Study of the therapeutic efficacy of a new ointment with a lipophilic complex of the Tremulin aspen bark under conditions of non-allergic contact dermatitis in rats. Pharmacology and drug toxicology. 2010;7–12.
Shlyapnykov V.N., Solodova T.L. et al. Eksperimentalnye modeli ostrykh pnevmoniy, vyzvanykh uslovno-patolohicheskimi bakteriyami I ikh assotsiatsiey: metod. ukazaniya sost. Saratov, 1998. 30 p.
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