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Journal of Education, Health and Sport

Research of effects by donators nitrogen of oxygen in complex therapy during experimental peritonitis
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Research of effects by donators nitrogen of oxygen in complex therapy during experimental peritonitis

Authors

  • I. V. Savytskyi Odessa National Medical University
  • S. V. Tsypoviaz Odessa National Medical University
  • R. G. Lenik State Enterprise Ukrainian Institute for Medicine of Transport of the Ministry of Health of Ukraine
  • O. V. Bilash Odessa National Medical University
  • R. H. Zashchuk Odessa National Medical University
  • I. V. Miastkivska Odessa National Medical University

DOI:

https://doi.org/10.12775/JEHS.2019.09.12.029

Keywords

peritonitis, experimental model, histological examination, correction, L-arginin

Abstract

The research was conducted on 175 white rats of reproductive age (3 months), weight of animals - 180-220 g. Animals were divided into 4 groups:

Group 1 - 20 intact animals. Group 2 - 50 rats with simulated fecal peritonitis.

Group 3 - 50 rats with simulated fecal peritonitis with subsequent antibiotic correction and debridement by chlorhexidine solution. Group 4 - 50 rats with simulated fecal peritonitis with subsequent antibiotic correction, chlorhexidine debridement and endothelial dysfunction  correction with the use of a nitric oxide donor.Fecal peritonitis was modeled using injection of 10% fecal suspension in a dose of 0.5 ml per100 gof animal weight in the abdominal cavity of laboratory animals by puncture method (Lazarenko V.A., et al., 2016, patent No. 233826).

The following results were obtained.

Histologically confirmed the development of experimental peritonitis in all groups of the experiment. In the group №2 on the third day the deterioration of the studied structures was established. In the group in which the experimental peritonitis was corrected by antibiotic therapy and chlorhexidine remediation, the effectiveness of the correction was morphologically proven. In group 4, macroscopic and microscopic examinations of the intestine, liver, and abdomen did not reveal significant differences from the histological picture we observed in rats of the intact group.

References

Brook I. Microbiological and management of abdominal infections. Dis. Dis. Sci. 2008;53;10:2585–2591.

Kondratenko PG, Kochetov EA. Rol' i mesto programmnyh sanacij brjushnoj polosti v hirurgicheskom lechenii razlitogo gnojnogo peritonita. Ukraїns'kij Zhurnal Hіrurgії. 2011;3;12:86–91.

Polivoda SN, Kolesnik JuM, Cherepok AA. Porazhenie organov mishenej pri gipertonicheskoj bolezne: prakticheskoe rukovodstvo. Chetverta hvilja. 2005:800.

Inagami T, Naruse M, Hoover R. Endothelium as an endocrine organ. Annu Rev Physiol. 1995;57:171-189.

Dzjubanovs'kij ІJa, Bedenjuk AD, Burak AЄ, Romanjuk TV. Dіagnostika endotelіal'noї disfunkcії v umovah sindromіv enteral'noї ta pechіnkovo-klіtinnoї nedostatnostі u hvorih z poshirenim peritonіtom. Klіnіchna anatomіja ta operativna hіrurgіja. 2014;13;2:34-37.

Sergienko VI, Petrosjan JeA, Tereshhenko OA, Botashev AA, Pomeshhik JuV, Hasaeva MA, Gubaz SG. Jendotelial'naja disfunkcija i metody ee korrekcii pri jeksperimental'nom zhelchnom peritonite. Hirurgija. Zhurnal im. N.I. Pirogova. 2012;3:54-58.

Lazarenko V.A., Lipatov V.A., Blinkov Ju.Ju., Skorikov D.V. Jeksperimental'naja model' rasprostranennogo kalovogo peritonita. Kurskij nauchno-prakticheskij vestnik "Chelovek i ego zdorov'e", 2008, № 4.S.128-132.

Pokrovskij M.V., Pokrovskaja T.G., Korchakov V.I. i dr. Jendotelioprotektornye jeffekty L-arginina pri modelirovanii deficita okisi azota. Jeksperim. i klin. farmakol. 2008; 71 (2): 29–31.

A. I. Gozhenko, A. A. Vasil'ev, V. M. Sirman, B. A. Nasibullin

Sravnitel'naja ocenka vlijanija ksenona na strukturnofunkcional'nuju harakteristiku pecheni pri raznoj patologii brjushnoj polosti. Vіsnik mors'koї medicini. 2015; 4(69):91-95.

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Published

2019-12-28

How to Cite

1.
SAVYTSKYI, I. V., TSYPOVIAZ, S. V., LENIK, R. G., BILASH, O. V., ZASHCHUK, R. H. and MIASTKIVSKA, I. V. Research of effects by donators nitrogen of oxygen in complex therapy during experimental peritonitis. Journal of Education, Health and Sport. Online. 28 December 2019. Vol. 9, no. 12, pp. 282-297. [Accessed 14 May 2025]. DOI 10.12775/JEHS.2019.09.12.029.
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Vol. 9 No. 12 (2019)

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Research Articles

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