Influence of magnesium on excitability of neurons of different levels of their organization
DOI:
https://doi.org/10.12775/JEHS.2019.09.11.029Keywords
magnesium, neuromuscular excitability, neurotransmission, stressAbstract
Abstract
The article indicates that the hyper-excitability of neurons is associated with ionic imbalance of cell membranes, in which a number of trace elements are involved. The energy component of these processes is associated with the presence of magnesium (Mg) as a universal supplier of the latter. Mg supports the functioning of NMDA receptors, which does not allow the excitotoxic effects of glutamate, which triggers the mechanisms of Ca entry into the neuron and its death, to manifest itself. Mg stimulates the main excitatory neurotransmitter acetylcholine, regulates the release of serotonin, glycine, dopamine, thereby normalizing the extrapyramidal system, the spinal stem structures, and the final executive motor apparatus. Participates in the energy support of adaptation processes, the activation of central regulatory mechanisms, control the excess of catecholamines and corticosteroids, other hormones and mediators involved in stress reactions.
References
Gunther T. The biochemical function of Mg 2+ in insulin secretion, insulin signal transduction and insulin resistance // Magnes. Res. 2010. № 23 (1). Р. 5–18.
Gromova O.A. Defitsit magniya kak problema stressa i dezadaptatsii u detey / O.A.Gromova, I.Yu.Torshin, T.R.Grishina, L.E. Fedotova // RMZh. 2012. #16. S. 813.
Mazur A., Maier J. A., Rock E. et al. Magnesium and the inflammatory response: potential physiopathological implications // Arch Biochem Biophys. 2007; 458 (1): 48–56.
Gromova O.A. Neyrotroficheskaya sistema mozga: neyropeptidyi, makro- i mikroelementyi, neyrotroficheskie preparatyi. Lektsiya / O.A.Gromova // Mezhdunarodnyiy nevrologicheskiy zhurnal 2(12) 2007 – S. 34-38.
Uholkina G.B. Rol magniya v zabolevaniyah serdechno–sosudistoy sistemyi / G.B.Uholkina // RMZh, # 7. – 2011. – S. 476.
Anesteziologiya. Kak izbezhat oshibok: Sb. – Pod red. K.Markuchcha, N.A.Koena i dr., M.: GETAR-Media, 2011
Gromova O.A. Magnievyie taynyi biblioteki Kohrana: sovremennyiy vzglyad na problemu / O.A.Gromova, E.Yu.Lisitsina, I.Yu.Torshin, O.N.Gracheva // Rossiyskiy Vestnik akushera-ginekologa, - # 5, 2011. – S. 20-27
Sokolova L.I. Zastosuvannya sulfatu magniyu pri Ishemichnomu insulti / L.I.Sokolova / / Ukrayinskiy nevrologichniy zhurnal, 2015. – # 4. – S. 91-97.
Ajeena I.M. (ed.) Advances in Clinical Neurophysiology Rieka: InTech, 2012. – 202 p.
Suponeva N.A. Myishechnyie krampi: voprosyi patogeneza, differentsialnoy diagnostiki i lecheniya / N.A.Suponeva, I.V.Borodulina // RMZh. 2015. #24. S. 1463-1466.
Yakimovskiy A.F., Varshavskaya V.M., Yakubenko A.L. Vnutristriarnoe vvedenie magniya posle pikrotoksina ne snizhaet dvigatelnuyu giperaktivnost u kryis. // Byul.eksperim.biologii i meditsinyi 2008; T.146, N8 – S. 128-13.
Fiziologiya cheloveka pod red. V.M.Pokrovskogo, G.F.Korotko- 2-e izd., pererab. i dop. – M.: 2003. – 656 s.
Illarioshkin S.N. Nedostatochnost magniya: nekotoryie nevrologicheskie aspektyi i puti korrektsii / S.N.Illarioshkin / Nervnyie bolezni. - #1, 2005. – S. 38-40
Korpachev V.V. Metabolicheskie effektyi i klinicheskoe primenenie magniya orotata / V.V.Korpachev, N.M.Gurina // Mezhdunarodnyiy endokrinologicheskiy zhurnal. – #2, 2007. – S. 23-28.
Torshin I.Yu. Molekulyarnyie roli magniya i piridoksina v antialkogolnoy zaschite organizma / I.Yu.Torshin, E.Yu.Egorova // Vrach, 2010. - # 7. – S. 51-54.
Tsirkin V.I. Rol gistamina v reproduktsii / V.I.Tsirkin, S.V. Hlyibova // Vyatskiy meditsinskiy vestnik, # 3-4, 2006. – S. 62-68.
Serov V.N. Ispolzovanie tsitrata magniya dlya profilaktiki prezhdevremennyih rodov u beremennyih s vyisokim riskom nevyinashivaniya / V.N.Serov, N.K. Tetruashvili. O.A.Gromova // RMZh, #17, 2012. – S. 846.
John A. Kiernan. Barr's the Human Nervous System: An Anatomical Viewpoint. – 8th. – Hagerstown, MD: Lippincott Williams & Wilkins, 2005.
Vetrile L.A. Vliyaniya antitel k glutamatu pri intranazalnom vvedenii na soderzhanie vozbuzhdayuschih i tormoznyih aminokislot v gippokampe i gipotalamuse kryis pri kombinirovannom stressornom vozdeystvii / L.A.Vetrile, I.A.Zaharova, V.S.Kudrin, P.M.Klodt // Patologicheskaya fiziologiya i eksperimentalnaya terapiya, 2016.-N 1.-S.4-10.
Kadyikov A.S.Magniy glazami nevrologa / A.S.Kadyikov, S.N.Busheneva // Zhurnal "Nervyi", 2006, #1. – S. 23-25
Karkashadze G.A. Defitsit magniya v detskoy nevrologii: chto nuzhno znat pediatru? / G.A.Karkashadze, L.S.Namazova-Baranova // Voprosyi sovremennoy pediatrii – 2014; 13 (5): 17-25.
Danbolt N.C.Glutamat euptake // Prog. Neurobiol. 2001. V.65. N1. P. 1-105.
Kryizhanovskiy G. N. Osnovyi obschey patofiziologii. – M.: MIA, 2011. – 253 s.
Ryan M.F., Babrour H. Magnesium measurement in routine clinical practice // Ann Clin Biochem., 1998 Jul;35 (Pt 4):449-59.
Ianello S. Belfore P. Hypomagnesemia. A review of pathophysiological, clinical and therapeutical aspects. - Panminerva Med. 2001 Sep;43 (3):177-209.
Kuznetsov V.V. Sovremennoe predstavlenie o roli GAMK v korrektsii neyrokardialnoy patologii / V.V.Kuznetsov, M.S.Egorova // Novosti meditsinyi i farmatsii. – # 11 (544) – 2015 – S. 4.
Budanov M.V. Klinicheskie proyavleniya i effektyi korrektsii defitsita magniya u detey / Budanova M.V., Aslanova P.A., Budanov P.V. // Trudnyiy patsient. – 2009. – # 1–2. – S. 17-22.
Sartori S.B., Whittle Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. - Neuropharmacology. 2012 Jan;62 (1) :304-12. doi: 10.1016/ j.neuropharm. 2011.07.027. Epub 2011.
Langeslag М., Clark К., Moolenaar W.H., 2007; Xing J., Strange К., 2009].
Fofanova I.Yu. Defitsit magniya i ego svyaz s akusherskoy patologiey /I.Yu.Fofanova // Meditsinskiy sovet" #5. – 2014. – S. 23-27
Rayssiguier Y, Mazur A. Magnesium and inflammation: lessons from animal models. Clin Calcium 2005;15(2):245–8
Yafarova G. G., Baltina T. V., Pleschinskiy I. N. Funktsionalnoe sostoyanie dvigatelnyih tsentrov spinnogo mozga v usloviyah ego travmaticheskogo povrezhdeniya / G. G. Yafarova, T. V. Baltina, I. N. Pleschinskiy. – Nizhnekamsk: Izd-vo NF MGEI. – 2008. – 74 s.
Bergeron M.F. Muscle Cramps during Exercise – Is It Fatigue or Electrolyte Deficit?// Current Sports Medicine Reports: doi: 10.1249/JSR.0b013e31817f476a.
Minetto M.A., Holobar A., Botter, Farina D. Origin and development of muscle cramps // Exerc Sport Sci Rev., 2013. vol. 41, N1.PP.3-10.
Obi T, Mizoguchi K, Matsuoka H, Takatsu M, and Nishimura Y: Muscle cramp as the result of impaired GABA function—an electrophysiological and pharmacological observation. Muscle Nerve 16:1228-1231, 1993.
Phisiology : Nextbook / Edited by V. Moroz, O.Shandra. – Vinnitsa : Nova Knyha Publishers, 2011. – 888 рр.
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