The role of prooxidative and antioxidant processes in periodontal tissue in the mechanisms of formation of adrenalin damage of myocardium and experimental periodontitis and their correction with Corvitin
DOI:
https://doi.org/10.12775/JEHS.2019.09.11.024Keywords
adrenaline damage of myocarditis, experimental periodontitis, corvitinAbstract
The aim of our study was to determine the antioxidant activity and prooxidative processes in the formation mechanisms in periodontal adrenalin myocardial damage and experimental periodontitis and their correction with corvitin. For this purpose, we conducted a study on 54 nonlinear white male rats, which were divided into six groups. First - control, second, third, fourth and fifth - a group of animals with adrenaline injury of myocarditis during the course of experimental periodontitis before correction of corvitin to according to the 1st, 7th, 10th and 17th days of the experiment and the sixth group - animals with adrenaline injury of myocarditis during the course of experimental periodontitis after adjustment corvitin. The results showed that when combined pathology antioxidant activity of prooxidative processes going towards depression of antioxidant protection against the growing LPO. After entering corvitin - reduced rates of LPO and increases the activity of enzymes AOC, that indicating the antioxidant and cardioprotective properties of the drug.
References
Ratmanov A. (2009). Cardiovascular morbidity and mortality - statistics for Eropean countries. Medicine Review. 1: 06-12.
Verezhnikova H. P. (2016). Electrocardiographic diagnosis of myocardial infarction. Family medicine. 1(63): 41-48.
Horodetsky O. T., Regeda M. S. (2019). Significance of lipoperoxidation processes and activity of antioxidant system in the myocardium under the conditions of development of adrenaline myocardial damage during experimental periodontitis and correction of their disorders with covariate. Achievements of Clinical and Experimental Medicine. 2(38): 93-98.
Mishchenko T. S., Dmitrieva E. V. (2018). Combination therapy with corvitin and axotilin in the treatment of patients with ischemic stroke. International Neurology Journal. 1(95): 31-36.
Rumyantsev, S. A., Ohanov, R. G., Silina, E. V., Stupin, V. A. and co-author. (2012). Modern concept for the treatment of patients with vascular comorbidity. Part 1. Tissue correction of energy deficiency. Cardiovascular therapy and prevention. 11(6): 44-49.
Vinichuk S. M., Prokopyv M. M., Cherenko T. M. (2010). Search for new approaches to the treatment of acute ischemic stroke. Ukrainian neurological journal. 1: 8-19.
Vinichuk S. M. (2010). The use of the new domestic drug corvitin in the treatment of acute ischemic stroke. Practical angiology. 4(33): 12-19.
Markova O. O. (1998). Myocardiodystrophy and reactivity of organism - Ternopil: Ukrmedkniha, 152.
Sukmanskyi O. I., Makarenko O. A. (2006). Experimental model of generalized periodontitis - Odessa: Journal of Dentistry. 2: 2-3.
Errick J, Heel R. (1983). Nalbuphine. Drugs. 26(3): 191-211.
Havrilov V. B., Myshkorudnaya M. I. (1989). Spectrophotometric determination of lipid hydroperoxide content in blood plasma. Laboratory diagnostics of coronary heart disease. K: Health,. 170-171.
Korobeinikova E. N. (1989). Modification of detemination of the products of lipid peroxidation in reaction with thiobarbituric acid. Lab. case. 7: 8-10.
Fried R. (1975). Enzymatik and non-enzymatic assay of superoxideifilii. Biochemie. 57(5): 657-660.
Holmes R., Masters C. (1970). Epigenetic interconversions of the multiple forms of mouse liver catalase. FEBS Lett. 11(11): 45-48.
Kolb V. G., Kamyshnikov V. S. (1982). Determination of activity of cereplasmin in blood; Handbook on clinical chemistry. Belarus 290-291.
Downloads
Published
How to Cite
Issue
Section
License
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 209
Number of citations: 0
