The role of interleukin-17 gene polymorphism (RS612242 C11139G) in the formation of the cryoglobulinemic syndrome in patients with chronic hepatitis C
Keywordschronic hepatitis C, HCV, Genetic Polymorphism, interleukin-17, cryoglobulinemia
Background. Chronic hepatitis C (CHC) is characterized by the development of extrahepatic symptom manifestations, which leads to an increased risk of mortality in these patients. Today, the factors contributing to the development of extrahepatic manifestations of CHC are being studied. Particular attention is paid to determining the clinical significance of cytokine gene polymorphism. Therefore, the aim of our work was study the role of interleukin-17 gene polymorphism (rs612242 C11139G) in the mixed cryoglobulinemia (MC) formation and manifestation of cryoglobulinemic syndrome in patients with chronic hepatitis C.
Materials and methods. The study included 149 patients with CHC and 45 healthy people. Determination of single-nucleotide IL-17 gene polymorphism (rs 612242 C11139G) was performed by real-time polymerase chain reaction. Statistical processing was performed in program "STATISTICA for Windows 13" (StatSoft Inc., No. JPZ804I382130ARCN10-J).
Results. We found that most often in patients with CHC (140 - 94.0%) and in healthy people (39 - 86.7%) was detected СС-genotype. It was found that the GG genotype was found to be significantly more likely in healthy subjects (χ2=20.5, p<0.0001). It was determined that patients with MC were significantly more likely to have a CC-genotype compared with healthy people (χ2=5.08, p<0.05), but the frequency of detection of this genotype was not statistically different compared with patients without MC (p>0.05). In patients with CHC carriers of the CC genotype of the IL-17 gene polymorphism significantly more likely (p<0.05), clinical signs associated with MC, namely weakness (65.6% vs. 40.0%), arthralgia (58.9% vs. 30.0%), vasculitis (14.4% vs. 2.0%) with the formation of the Meltzer’s triad (14.4% vs. no formation). It was showed that type 2 diabetes was significantly more likely to be detected in patients without MC (χ2=5.52, p<0.05).Conclusion. Allele C of the IL-17 gene polymorphism has an effect on the chronicity of hepatitis C according to a multiplicative model of inheritance. The CC-genotype plays a role in the formation of HCV-associated MC. Weakness, arthralgia and vasculitis with the formation of the Meltzer’s triad are the most common manifestations of cryoglobulinemic syndrome.
Lee, M., Yang, H., Lu, S., Jen, C., You, S., & Wang, L. et al. (2012). Chronic Hepatitis C Virus Infection Increases Mortality From Hepatic and Extrahepatic Diseases: A Community-Based Long-Term Prospective Study. Journal Of Infectious Diseases, 206(4), 469-477. doi: 10.1093/infdis/jis385.
Russi, S., Sansonno, D., Mariggiò, M., Vinella, A., Pavone, F., & Lauletta, G. et al. (2014). Assessment of total hepatitis C virus (HCV) core protein in HCV-related MC. Arthritis Research & Therapy, 16(2), R73. doi: 10.1186/ar4513.
Roccatello, D., Sciascia, S., Rossi, D., Solfietti, L., Fenoglio, R., Menegatti, E., & Baldovino, S. (2017). The challenge of treating hepatitis C virus-associated cryoglobulinemic vasculitis in the era of anti-CD20 monoclonal antibodies and direct antiviral agents. Oncotarget, 8(25). doi: 10.18632/oncotarget.16986.
Mazzaro C, Monti G, Saccardo F, Zignego AL, Ferri C, De Vita S, Gabrielli A, Lenzi M, Donada C, Galli M, Pietrogrande M, Pozzato G. Efficacy and safety of peginterferon alfa-2b plus ribavirin for HCV-positive MC: a multicentre open-label study. Clin Exp Rheumatol. 2011;29(6):933-41.
Terrier, B., Semoun, O., Saadoun, D., Sène, D., Resche-Rigon, M., & Cacoub, P. (2011). Prognostic factors in patients with hepatitis C virus infection and systemic vasculitis. Arthritis & Rheumatism, 63(6), 1748-1757. doi: 10.1002/art.30319.
Smolnikova, M., Barilo, A., & Smirnova, S. (2018). POLYMORPHISM OF CYTOKINE GENES (IL17A AND IL17F) IN PSORIASIS AND PSORIATIC ARTHRITIS. Siberian Medical Review, (5), 48-53. doi: 10.20333/2500136-2018-5-48-53.
Singh, R., Hasan, S., Sharma, S., Nagra, S., Yamaguchi, D., & Wong, D. et al. (2014). Th17 cells in inflammation and autoimmunity. Autoimmunity Reviews, 13(12), 1174-1181. doi: 10.1016/j.autrev.2014.08.019
Chen, J., Deng, Y., Zhao, J., Luo, Z., Peng, W., & Yang, J. et al. (2010). The Polymorphism of IL-17 G-152A was Associated with Childhood Asthma and Bacterial Colonization of the Hypopharynx in Bronchiolitis. Journal Of Clinical Immunology, 30(4), 539-545. doi: 10.1007/s10875-010-9391-8
Kim, E., Kim, S., Moon, C., Park, J., Kim, T., Kim, W., & Cheon, J. (2012). Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population. Life Sciences, 90(19-20), 740-746. doi: 10.1016/j.lfs.2012.03.017
Holz, L., Yoon, J., Raghuraman, S., Moir, S., Sneller, M., & Rehermann, B. (2012). B cell homeostasis in chronic hepatitis C virus-related MC is maintained through naïve B cell apoptosis. Hepatology, 56(5), 1602-1610. doi: 10.1002/hep.25821.
Li, J. (2014). Interleukin-17 SNPs and serum levels increase ulcerative colitis risk: A meta-analysis. World Journal Of Gastroenterology, 20(42), 15899. doi: 10.3748/wjg.v20.i42.15899
Dai, Z., Zhang, T., Lin, S., Zhang, W., Liu, J., & Cao, X. et al. (2016). Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: an updated meta-analysis. Scientific Reports, 6(1). doi: 10.1038/srep20439
ELBassuoni, M., Abd El Fatah, G., & Zaghla, H. (2015). IL17A gene polymorphism, serum IL17 and total IgE in Egyptian population with chronic HCV and hepatocellular carcinoma. Immunology Letters, 168(2), 240-245. doi: 10.1016/j.imlet.2015.09.004
Bulatova, I. A. (2014). INVESTIGATION OF INTERLEUKIN-17 AND INTERLEUKIN-17F GENE (RS763780) POLYMORPHISM IN CHRONIC HEPATITIS C. Perm Medical Journal, 31(1), 103-108. doi: 10.17816/pmj311103-108
Kalashnyk, K., Riabokon, Y., & Riabokon, O. (2019). Interaction of polymorphism of the interleukin-6 gene with immunological damages and their role in the development of MC in patients with chronic hepatitis C. Pathologia, 0(1), 27-32. doi: 10.14739/2310-1237.2019.1.166189
Ossi, E., Bordin, M.C., Businaro, M.A., Marson, P., Bonadonna, P., Chiaramonte, M., Boin, F., Valenti, M.T., & Fagiolo, U. (1995). HLA expression in type II MC and chronic hepatitis C virus. Clinical and experimental rheumatology, 13 Suppl 13, S91-3 .
Lenzi, M., Frisoni, M., Mantovani, V., Ricci, P., Muratori, L., & Francesconi, R. et al. (1998). Haplotype HLA-B8-DR3 Confers Susceptibility to Hepatitis C Virus-Related MC. Blood, 91(6), 2062-2066. doi: 10.1182/blood.v91.6.2062.2062_2062_2066
Dammacco, F., Sansonno, D., Piccoli, C., Tucci, F., & Racanelli, V. (2001). The cryoglobulins: an overview. European Journal Of Clinical Investigation, 31(7), 628-638. doi: 10.1046/j.1365-2362.2001.00824.x
Ferri, C. (2008). MC. Orphanet Journal Of Rare Diseases, 3(1). doi: 10.1186/1750-1172-3-25
Palshina, S., & Vasil'ev, V. (2010). KRIOGLOBULINEMIChESKIY VASKULIT. Rheumatology Science And Practice, 0(4), 59. doi: 10.14412/1995-4484-2010-1167
Milovanova S.Y., Kozlovskaya L.V., Gordovskaya N.B. POLYMORPHISM OF CLINICAL MANIFESTATIONS OF CRYOGLOBULINEMIA-RELATED VASCULITIS ASSOCIATED WITH CHRONIC HEPATITIS С VIRUS INFECTION. Almanac of Clinical Medicine. 2014;(30):46-51. (In Russ.) https://doi.org/10.18786/2072-0505-2014-30-46-51
Onishchenko, N., Riabokon, Y., & Riabokon, O. (2018). The role of interleukin-10 gene polymorphism (rs 1800872) in the course of herpes zoster in adults. Pathologia, 0(325-329), 325. doi: 10.14739/2310-1237.2018.3.151810
How to Cite
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Number of views and downloads: 194
Number of citations: 0