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Journal of Education, Health and Sport

New view on alcoholic liver disease - potential role of PD1/PDL-1 pathway in the disease pathogenesis
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New view on alcoholic liver disease - potential role of PD1/PDL-1 pathway in the disease pathogenesis

Authors

  • Katarzyna Adamczyk Department of Gastroenterology with Endoscopic Unit Medical University of Lublin https://orcid.org/0000-0003-4861-7686
  • Beata Kasztelan-Szczerbińska Department of Gastroenterology with Endoscopic Unit Medical University of Lublin https://orcid.org/0000-0002-7198-4428
  • Anna Rycyk Department of Gastroenterology with Endoscopic Unit Medical University of Lublin https://orcid.org/0000-0001-5625-0330
  • Halina Cichoż-Lach Department of Gastroenterology with Endoscopic Unit Medical University of Lublin https://orcid.org/0000-0002-7337-835X

DOI:

https://doi.org/10.12775/JEHS.2019.09.11.009

Keywords

alcohol liver disease (ALD), immune dysregulation, programmed cell death 1 (PD-1), gender difference

Abstract

Introduction: Exposure to chronic, excessive alcohol consumption, its breakdown metabolites, and gut-derived endotoxins dysregulate immune signaling leading to activation of inflammation. As a result, the non-resolving inflammatory response and development of alcoholic liver disease (ALD) may occur. There are still no pharmacological or nutritional therapies for treating patients with alcoholic liver disease. Material and Methods: The information provided was collected as a result of various article’s analyses on the development, diagnosis, and treatment of patients with alcoholic liver disease using Google Scholar and PubMed databases. Results: The pathway consisting of the programmed cell death 1 (PD-1) receptor and its ligand PD-L1 may play a critical role in the inhibition of self-reactive and inflammatory effector cells and the protection against immune-mediated tissue damage. There is a possibility of the potential gender-related differences in PD1/PD-L1 signaling in ALD. Conclusion: The better understanding of ALD as a dynamic process and all aspects of immune dysregulation may be important for the development of novel therapies in alcoholic liver disease. Results from a further study on the PD1/PDL-1 pathway might be exploited to re-define therapeutic targets and create sex-tailored treatments according to individual patient needs.

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Published

2019-11-17

How to Cite

1.
ADAMCZYK, Katarzyna, KASZTELAN-SZCZERBIŃSKA, Beata, RYCYK, Anna and CICHOŻ-LACH, Halina. New view on alcoholic liver disease - potential role of PD1/PDL-1 pathway in the disease pathogenesis. Journal of Education, Health and Sport. Online. 17 November 2019. Vol. 9, no. 11, pp. 121-127. [Accessed 1 July 2025]. DOI 10.12775/JEHS.2019.09.11.009.
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Vol. 9 No. 11 (2019)

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Research Articles

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