Influence of mineral water of well No. 3 of Semyanivka village of Poltava district of Poltava region (Ukraine) on the structural and functional state of the kidneys with experimental nephritis
DOI:
https://doi.org/10.12775/JEHS.2019.09.11.008Keywords
mineral water, structural and functional state kidneys, experimental nephritis.Abstract
In an experiment on white rats with toxic nephritis, pathological changes in the structural and functional state of the kidneys were determined. An increase in the daily diuresis (p <0.001) was found, due to an increase in the glomerular filtration rate by (p <0.001) and a significant decrease in the percentage of fluid back-suction (p <0.001). The excretion of creatinine and urea increased by (p <0.01), and the excretion of chloride ions, on the contrary, decreased (p <0.01). Application on the background of the development of low-mineralized silicon chloride-hydrocarbonate sodium water leads to partial normalization of kidney function - the volume of diuresis is moderately restored by increasing the tubular reabsorption against the background of a significant increase in the glomerular filtration rate and a significant increase in the amount of silica. The manifestations of inflammation in the kidneys disappear, but the destructive changes of the nephrons remain. The partial restoration of the activity of redox enzymes has been established.
References
Cruz MC, Andrade C, Urrutia M, Draibe S, Nogueira-Martins lA. Quality of life in patients with chronic kidney disease. Clinics (Sao Paulo). 2011;66(6):991 – 995. doi: 10.1590/s1807-59322011000600012.
Matsushita К, Chen J, Sang Y, Ballew SH, Shimazaki R, Fukagawa M, Imai E, Coresh J., Hishida A. Risk of end-stage renal disease in Japanese patients with chronic kidney disease increases proportionately to decline in estimated glomerular filtration rate. Kidney Int. 2016;90(5):1109 – 1114. doi: 10.1016/j.kint.2016.08.003.
Vakulenko LI. Pylonephritis in girls: features at the modern stage. Ukranian Journal of Nephrology and Dialysis. 2018;1(57):38 – 43.
file:///C:/Users/user/Downloads/35-35-PB.pdf.
Yamawaki K., Kanda H., ShimazakI R. Nrf2 activator for the treatment of kidney diseases. Toxicology and Applied Pharmacology. 2018. Vol. 360. P. 30 – 37. https://doi.org/10.1016/j.taap.2018.09.030.
Petraccia L, Liberati GL, Masciullo SG, Grassi М, Fraioli А. Water, mineral waters and health. Clin Nutr. 2006:25(3):377 – 385. doi: 10.1016/j.clnu.2005.10.002.
Zolotareva TA, Babov KD, Nasibullin BA, Kozyavkin VI, Torokhtin AM, Yushkovskaya OG. Medical rehabilitation. Kyiv: КІМ, 2012. 496 р.
Zabolotna IB, Gushcha SG, Mikhailenko VL. Non-alcoholic fatty liver disease and mineral waters of Ukraine – opportunities of application (experimental-clinical studies). Balneo Research Journal. 2018;9(3):270 – 276.
doi: 10.12680/balneo.2018.194.
Moiseev AYu. Features of the chemical composition and balneological use of mineral waters / Ed. by VP. Shestopalova, NP. Moiseeva. Kiev: KIM, 2017. 446 р.
Medical-hydrogeochemical factors of geological environment in Ukraine / Ed by HI. Rudko. Kyiv - Chernovtsy: Bukrek, 2015: 724 р.
Rakhmanin YuA, Egorova NA, Krasovsky GN, Mikhailova RI., Alekseeva AV. Silicon: its biological impact under dietary intake and hygienic standardization of its content in drinking water. A review. Hygiene & Sanitation (Russian Journal). 2017; 96(5) DOI: http://dx.doi.org/10.1882/0016-9900-2017-96-5-492-498.
Santra S., Guha P. K., Ali S. Z., Haneef I., Udrea F. Silicon on insulator diode temperature sensor – A detailed analysis for ultra-high temperature operation. IEEE Sensor J. 2010;10(5): 997 – 1003.
Jurkic LM, Cepanec I, Pavelic SK, Pavelic K. Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid – releasing compounds: New perspectives for therapy. Nutrition & Metabolism. 2013;10(2). https://doi.org/10.1186/1743-7075-10-2.
Dzhioev IG. The influence of TIB-2 mineral water on the secretion of gastrin and pepsin, on the state of g-cells of the stomach. International Journal of Applied and Fundamental Research. 2017;7(1):84-86. URL: https://applied-research.ru/ru/article/view?id=11697.
Gushcha SG. Tо the mechanisms of correcting influence of mineral waters of different osmolyarity and microelement composition on the structural-functional state of kidneys of rats with experimental nephritis. Bulletin of problems biology and medicinе. 2018;2(144):301 – 306.
file:///C:/Users/user/Downloads/Vpbm_2018_2_74.pdf
Instruction 2010/63/EU of European Parliament and Council on animals used for research and other purposes protection. Official Journal. 2010;276:33–79.
Order of MOH of Ukraine No. 692 dated 28.09.2009 «On approval of the recommendations of the research methods of biological effects of natural medicinal resources and preformed remedies».
Nasibullin BA, Gushcha SG, Babov KD, Trubka IO. еt al A guide to the reproduction of experimental models of common nosological forms and their verification]. Odessa. 2018:82 р.
Order of MOH of Ukraine No. 692 dated 28.09.2009 «On approval of the recommendations of the research methods of biological effects of natural medicinal resources and preformed remedies».
Mineral healing waters. Technical conditions GSTU 42.10.02-96. Kiev: State Standard of Ukraine, 1996. 30 р.
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