Clinical consequences of perinatal hypoxic-ischemic lesions of the central nervous system in infants born prematurely
Keywordsperinatal hypoxic-ischemic lesion, central nervous system, infants born prematurely, motor function
In the course of work, in order to study the leading risk factors for the unfavorable prognosis of development of impaired motor function in children born prematurely who underwent perinatal hypoxic-ischemic brain injury, a comprehensive examination of 79 children at an average age of 3.2 ± 1.3 years, who suffered from perinatal hypoxic-ischemic lesions of the central nervous system, and who were born prematurely, was conducted. As shown by the results of the survey, in 20.3% of the surveyed, it was found spastic cerebral palsy with severe motor disorders of the 4-5th levels according to the Gross Motor Function Classification System (GMFCS); 37.9% had spastic diplegia, 22.6% of which had motor disorders of the 3rd level by GMFCS, 15.3% had motor disorders of the 2nd level; 27.8% were diagnosed with hemiplegic form of cerebral palsy with the 1st level of motor disorders. 14.0% were diagnosed with acquired post-hemorrhagic hydrocephalus, 63.6% were operated on up to 6 months of age, they were implanted with liquor-bypass system and had motor disorders of the 1-2nd level; 27.3% of children were operated on after 6 months of life and had motor disorders of the 3rd level, and 9.1% were not operated on and had the 5th level of motor disorders. It has been established that the most important factors that form the difficult motor prognosis are gestational age of 27 - 30 weeks, peri-intraventricular hemorrhages of 2-4 degrees, periventricular leukomalacia of the 3rd degree, presence of signs of periventricular ischemia. Predictors of the formation of severe disorders of motor functions (inability to absorb walking, mastered only walking with auxiliary devices) in premature infants are pronounced ischemic brain injury, spastic form of cerebral palsy, operated on after 6 months of life, or generally non-operative acquired post-hemorrhagic hydrocephalus, gestational age 27 - 30 weeks, peri-intraventricular hemorrhage of 2-4 degrees, periventricular leukemalacia of the 3rd degree.
An intention to achieve better postnatal inыhospitalыgrowth for preterm infants: Adjustable protein fortification of human milk / S. Alan, B. Atasay, U. Cakir [et al.] // Early Hum. Dev. — 2013. — Sep. 12.
Znamenska TK Strategic directions of reconstruction of the health care system for newborns and children of Ukraine / T.K. Znamenska, OV Vorobyova, T.Yu. Dubinina // Neonatology, surgery and perinatal medicine. - 2017. - № 4 (26). - P. 5 - 12.
Prevalence of cerebral palsy in 8-year-old children in three areas of the United States in 2002: a multisite collaboration. Yeargin-Allsopp M, Van Naarden Braun K, Doernberg NS, Benedict RE, Kirby RS, Durkin MS.Pediatrics. 2008 Mar; 121(3):547-54.
Martyniuk V.Yu. Cerebral palsy / V.Yu. Martyniuk // Social Pediatrics and Rehabilitation. - 2012. - № 1 (2). - P. 18-23.
Palchik A.B. Neurology of premature babies / A.B.Palchik L.A., Fedorova A.E., Ponyatishin A.E. - 3rd ed. - M .: MEDpress-inform, 2012. - 352 p.
Pakula AT, Van Naarden Braun K, Yeargin-Allsopp M. Cerebral palsy: classification and epidemiology. Phys Med Rehabil Clin N Am. 2009 Aug; 20(3):425-52.
Bax M., Goldstein M., Rosenbaum P., Leviton A., Paneth N., Dan B., Jacobsson B., Damiano D. Executive Committee for the Definition of Cerebral Palsy. Proposed definition and classification of cerebral palsy, April 2005. Dev Med Child Neurol. 2005 Aug; 47(8):571-6.
Kachmar OO System of classification of large motor functions in children with cerebral palsy.// International Journal of Neurology, 2008. - №1 (17). - P. 90–93.1
Morris C., Bartlett D. Gross Motor Function Classification System: impact and utility //Developmental Medicine and Child Neurology. – 2004. – V. 46. – P. 60–65.
Shevchenko L.A. Perinatal motor syndromes and their therapeutic correction: a monograph for neonatologists, pediatricians, neurologists, family doctors, interns, students of higher. honey. textbook. institutions / L.A. Shevchenko, V.I. Bobrov. - Z: "Enlightenment", 2017. – 158 p.
Prediction of early clinical severity and extent of neuronal damage in anterior-circulation infarction using the initial serum neuron-specific enolase level. / S.H. Oh, J.G. Lee, S.J. Na at. al. // Arch. Neurol. – 2003. – № 60(1). – Р. 37-41.
Classification system of large motor functions (GMFCS) // All about cerebral palsy. Information for patients, their families and specialists [Electronic resource]. - Access mode URL: http://www.dcp.com.ua/GMFCS
How to Cite
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Number of views and downloads: 325
Number of citations: 0