Main mechanisms and features of epileptogenesis of post-traumatic epilepsy
Keywords
post-traumatic epilepsy, epileptogenesis, risk factorsAbstract
One of the most frequent and formidable consequences of traumatic brain injury (TBI) is post-traumatic epilepsy (PTE), which is the main identified cause of symptomatic epilepsy at a young age.
The work highlights the "trigger" mechanisms of brain damage, including oxidative stress, leading to the disintegration of all levels of the central nervous system, contributing to the development of neuropathological syndromes, and especially PTE.
The questions of differentiation of PTE from other epileptic paroxysms, the dependence of the development of PTE on the severity of TBI, the main risk factors for this type of epileptogenesis, its phasing, as well as disorganization and damage to the antiepileptic system are considered. The place of a nonspecific response to damage in the form of immediate and early seizures, their metamorphosis as the formation of PTE was determined.
The existing spectrum of convulsive seizures is described, including partial, taking into account the localization characteristic of TBI with a predominance of lezional forms.
References
Isaeva R.KH. Immunologicheskie izmeneniya pri cherepno-mozgovoj travme / R.KH.Isaeva, I.А.Аvtonyuk, А.V.Gridyakina, А.E.Evstaf'eva // Mezhdunarodnyj zhurnal prikladnykh i fundamental'nykh issledovanij. – 2014. – № 8 (chast' 2) – S. 41-47
Seo W. Comparisons of acute physiological parameters influencing outcome in patients with traumatic brain injury and hemorrhagic stroke / W. Seo, H. Oh // Worldviews Evid. Based Nurs. - 2009. - Vol. 6. N 1. - P. 36-43.
Niizuma K. Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival / K. Niizuma, H. Endo, P.H. Chan // J. Neurochem. - 2009. - Vol. 109, Suppl. 1. - S. 133-138.
Boldyirev A.A. Svobodnyie radikalyi v normalnom i ishemicheskom mozge / A.A. Boldyirev, M.L. Kukley // Neyrohimiya. - 1996. - T.13. - S. 25-29.
Dizregulyatsionnaya patologiya nervnoy sistemyi / pod red. E.I.Guseva, G.N. Kryizhanovskogo. – M. : OOO «Meditsinskoe informatsionnoe agentstvo», 2009. - 512 s.
Kurbanova S.A. Kliniko-neyrofiziologicheskie osobennosti simptomaticheskoy posttravmaticheskoy epilepsii Avtoref.diss... k.med.n. - M., 2007. - 18 s.
Haltiner A.M., Temkin N.R., Dikmen S.S. Risk of seizure recurrence after the first late posttraumatic seizure. Arch Phys Med Rehabil 1997;(78):835—40.
Zaytsev O.S. Rannie sudorozhnyie pristupyi i posttravmaticheskaya epilepsiya / O.S.Zaytsev, O.A.Grinenko, G.G.Shaginyan // Neyrohirurgiya i nevrologiya Kazahstana . - # 4 (21), 2010. - S.20-24
Savitskiy I.V. Endotelialnaya disfunktsiya pri posttravmaticheskoy epilepsii / I.V.Savitskiy, A.A.Mironov, I.V.Myastkovskaya / Jornal of Education, Health and Sport. 2016; 6 (6) ; 245-252.
Alekseenko Yu.V. Posttravmaticheskaya epilepsiya: problemyi diagnostiki, lecheniya i profilaktiki / Yu.V.Alekseenko // Meditsinskie novosti. - # 11, 2006. - S 25-28.
Bramlett H.M. Патофизиология ишемического и травматического поражения мозга: сходство и различия / H.M.Bramlett, W.D.Dirtrich // Медицина неотложных состояний. - 2006. - № 5. - С. 36-43.
Volohova G.A. Intensifikatsiya protsessov lipoperoksidatsii i ugneteniya aktivnosti antiradikalnyih mehanizmov kak odnonapravlennyie mehanizmyi povrezhdeniya mozga / G.A.Volohova, A.N.Stoyanov, R.S.Vastyanov // LIki UkraYini. - # 5 (131) / 2009. - S. 92-97.
Hertsev V. N., Stoyanov A. N., Bocherova T. I. Applied clinical and pathogenetic aspects of interdisciplinary cooperation in the diagnosis and treatment of concussion of brain. Journal of Education, Health and Sport. 2017;7 (5):913-927.
Ding K, Gupta PK, Diaz-Arrastia R. Laskowitz D, Grant G, editors. Translational Research in Traumatic Brain Injury. Boca Raton (FL): CRC Press/Taylor and Francis Group; 2016. Chapter 14.
Pesochina E.A. Znachenie nasledstvenno-konstitutsionalnyih faktorov v formirovanii otdalennyih posledstviy cherepno-mozgovoy travmyi Avtoref. diss... k.med.n. - Harkov - 1989 - 23s.
Grimaylo V.N. Osobennosti sindroma vegetativnoy distonii u patsientov s posttravmaticheskoy epilepsiey / V.N.Grimaylo, T.A.Litovchenko, Yu.V.Yakubenko, T.V.Markova // Mezhdunarodnyiy meditsinskiy zhurnal. - #3, 2015. - S 32-35.
Barhatov M.V. Primenenie preparata Meksidol v kompleksnom lechenii detey s posttravmaticheskoy epilepsiey / M.V. Barhatov, A.V. Nosyirev, A.V. Dehtyar, M.Yu. Galaktionova // Byulleten eksperimentalnoy biologii i meditsinyi, 2006, prilozhenie 1 - S. 9-13.
Hervan S.T. Epilepsy after brain insult: targeting rpileptogenesis. Neurology, 2002; 59 (Suppl. 10).
Antonawich F.J., Azmitia E.C., Kramer H.K., Strand F.L. Specificity versus redundancy of melanocortins in nerve regeneration // Ann. NY Acad. Sci., 1994, v. 739, Р. 60-73.
Nevrologiya. Natsionalnoe rukovodstvo - Gusev E. I., Konovalov A. N., Skvortsova V. I., Geht A. B. - M.: GOETAR-Media- 2013 god - 1040 s.
Gardner Govard Struktura razuma: teoriya mnozhestvennogo intellekta : Per. s angl. - M.: OOO "I.D.Vilyams", 2007. - 512 s.
Magnitskaya K.B. Epileptogenez i patogeneticheskaya terapiya / Epilepsiya u detey: problemyi i resheniya. - Materialyi mezhd. konf. - Volgograd, 2007. - S.6-13.
Patofiziologiya: rukovodstvo k prakt. zanyatiyam: Uchebnoe posobie / pod red. V.V.Novitskogo, O.I.Urazovoy. - M., 2011. - 336 s.
Vastyanov R.S. FunktsIonalna perebudova ta zmIna lokalIzatsIYi korkovih motornih neyronIv v umovah hronIchnoYi epIleptichnoYi aktivnostI / R.S.Vastyanov, O.A.Shandra // Tavricheskiy mediko-biologicheskiy vestnik. - 2012. - t. 15. - # 3. - S. 51-53.
Avakyan G.N., Generalov V.O., Oleynikova O.M. i dr. Simptomaticheskaya posttravmaticheskaya epilepsiya. Klinika, diagnostika i lechenie. // Metodicheskie rekomendatsii. M. 2004. - 40 s.
Guzeva V.I. Epilepsiya i neepilepticheskie paroksizmalnyie sostoyaniya u detey. — M.: OOO «Meditsinskoe informatsionnoe agentstvo», 2007. — 568 s.
Generalov V.O. Epilepsiya i strukturnyie povrezhdeniya mozga Avtoref.diss... d.med.n. - M., 2010. - 35 s.
Generalov V.O., Mishnyakova L.P., Fedin A.I. Vliyanie lokalizatsii ochaga epilepticheskoy aktivnosti na sroki razvitiya posttravmaticheskoy epilepsii.// Materialyi X Vserossiyskogo s'ezda nevrologov. Yaroslavl. 2006 - S. 535.
Fazel S. et al. Premature mortality in epilepsy and the role of psychiatric comorbidity: a total population study //The Lancet. – 2013. – Т. 382. – №. 9905. – С. 1646-1654.
Feeney DM, Walker AE. The prediction of posttraumatic epilepsy. A mathematical approach. Arch Neurol 1979;36:8–12.
De Carolis P, D’Alessandro R, Ferrara R, et al. Late seizures in patients with internal carotid and middle cerebral artery occlusive disease following ischaemic events. J Neurol Neurosurg Psychiatry 1984;47:1345–1347.
Faught E, Peters D, Bartolucci A, et al. Seizures after primary intracerebral hemorrhage. Neurology 1989;39:1089–1093.
Willmore LJ, Sypert GW, Munson JB. Recurrent seizures induced by cortical iron injection: a model of post-traumatic epilepsy. Ann Neurol 1978;4:329–336.
Aisen P. Some Physicochemical Aspects of Iron Metabolism. In Ciba Foundation Symposium (51st ed). New York: Elsevier, 1977:1–14.
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