Correlation between miR-146a and miR-155 levels and concentration of cytokines in patients with allergopathy in chronic persistence of Epstein-Barr virus infection
Keywordscytokines, miR-146a, miR-155, chronic Epstein-Barr virus infection, allergopathy
AbstractAnalysis of correlation between miR-146a and miR-155 levels and concentration of antiviral cytokines in patients with allergopathy in active and latent phases of chronic persistence of Epstein-Barr virus infection (EBV) has been conducted. Thus, 38 patients with allergopathy and chronic persistence of EBV of different genders, age 32.73.2 years have been examined, who were divided into groups depending on the phases of virus persistence. Control group included 20 healthy individuals. Reliable changes in IL12, IL33, IL1ß and IFN- were revealed in patients of both groups. The results: reliably higher levels of miR-146a expression, by 2.9 times (р=8.0E-04) and by 2.25 times (р=0.011), respectively, compared with control group; reliable difference in miR-155 levels in patients with EBV-infection in active and latent forms of virus persistence (р=1.0E-07) and significant decrease in the indicated miRNA (р=1.0E-07) by 55.8 times in patients with latent course of EBV-infection compared with control. A reliable reverse correlation of various intensities was detected between IL12, IL1ß, IFN- and miR-146a; absence of correlation between TNF-α, IL33 and miR-146a was observed. A direct correlation was revealed between all investigated cytokines IL12, TNF-α, IL33, IL1ß, IFN- and miR-155. the results of investigation showed that elevation of miR-146a can prognostically indicate inhibition of pro-inflammatory activity of cytokines and anti-inflammatory protection with the formation of pathological disorders, including allergopathy. Meanwhile, the presence of chronic persistence of EBV demonstrates an opposite direction of correlations between miR-155 and cytokines with pro-inflammatory properties, which confirms the ability of opportunistic infections to modulate immune response toward allergopathy.
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