Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

Comparison of the diagnostic efficiency of various noninvasive methods for diagnosing liver fibrosis in patients with chronic viral hepatitis C
  • Home
  • /
  • Comparison of the diagnostic efficiency of various noninvasive methods for diagnosing liver fibrosis in patients with chronic viral hepatitis C
  1. Home /
  2. Archives /
  3. Vol. 9 No. 6 (2019) /
  4. Research Articles

Comparison of the diagnostic efficiency of various noninvasive methods for diagnosing liver fibrosis in patients with chronic viral hepatitis C

Authors

  • L. V. Moroz National Medical University. M.I. Pirogov Department of Infectious Diseases with a course of epidemiology
  • I. Yu. Bondaruk National Medical University. M.I. Pirogov Department of Infectious Diseases with a course of epidemiology
  • A. A. Popovich National Medical University. M.I. Pirogov Department of Infectious Diseases with a course of epidemiology
  • S. N. Kulias National Medical University. M.I. Pirogov Department of Infectious Diseases with a course of epidemiology

Keywords

chronic viral hepatitis C, fibrosis, hyaluronic acid, fibroelastography

Abstract

Summary: the article presents the results of the examination of patients with chronic viral hepatitis C namely the study of the informativeness of instrumental (fibroelastography) and serological (the content of hyaluronic acid in serum) of markers of fibrosis by assessing their predictive value by ROC- analysis. The purpose of the study: to find out the possibility of non-invasive methods for diagnosing liver fibrosis in patients with chronic viral hepatitis C (CHC). Materials and methods 66 patients with CHC with the 1-st genotype of the virus were examined, which were at the dispensary observation and ambulatory treatment at DCC CCH №1 in Vinnitsa and in the clinical department of viral hepatitis at the Institute of Epidemiology and Infectious Diseases named after L.V. Gromashevsky NAMS of Ukraine. All patients received fibroelastography (FEG) with a METAVIR score. All patients with CHC and group of control determined the content of hyaluronic acid (GA) in blood serum (ELISA using the Hyaluronic Acid (Corgenix, Inc., USA)). Research results Sensitivity of determination of GA in blood serum of patients with CHC with degree of fibrosis of liver F0-F2 was 91.23%, and specificity - 90.46%. For the FEG method, respectively: 74.33% and 77.25%. In the group of patients with degree of fibrosis F3 sensitivity of the definition of GA in blood serum was 72.21%, and specificity - 74.71%. The corresponding qualitative characteristics for FEG were: 98.32% and 91.45% respectively. The sensitivity of the determination of the content of GA in serum of patients with CHC with the degree of liver fibrosis F4 was 88.23%, and the specificity was 92.12%. For these patients the sensitivity and specificity of determining the degree of fibrosis by the FEG method were 87.78% and 91.45% respectively. Conclusions High diagnostic efficiency of determination of the content of GA in serum was established for assessing the degree of liver fibrosis in patients with CSF (AUC = 0,720-0,917, p˂0,01). Relatively higher sensitivity and specificity of the diagnosis of liver fibrosis was observed in determining the content of GA in serum compared with the FEG method (AUC = 0.914 vs. AUC = 0.817 (p˂0.05)) in the group with a lack or initial signs of liver fibrosis (F0-F2).

Downloads

  • PDF

Published

2019-06-28

How to Cite

1.
MOROZ, L. V., BONDARUK, I. Yu., POPOVICH, A. A. and KULIAS, S. N. Comparison of the diagnostic efficiency of various noninvasive methods for diagnosing liver fibrosis in patients with chronic viral hepatitis C. Journal of Education, Health and Sport. Online. 28 June 2019. Vol. 9, no. 6, pp. 546-555. [Accessed 18 May 2025].
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 9 No. 6 (2019)

Section

Research Articles

License

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 319
Number of citations: 0

Search

Search

Browse

  • Browse Author Index
  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

chronic viral hepatitis C, fibrosis, hyaluronic acid, fibroelastography
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop