Humanities
Skip to main content Skip to main navigation menu Skip to site footer
  • Register
  • Login
  • Menu
  • Home
  • Current
  • Archives
  • Announcements
  • About
    • About the Journal
    • Submissions
    • Editorial Team
    • Privacy Statement
    • Contact
  • Register
  • Login

Journal of Education, Health and Sport

Selected Cutaneous and Mucocutaneous Manifestations Associated with Inflammatory Bowel Disease: Diagnostic and Therapeutic Implications
  • Home
  • /
  • Selected Cutaneous and Mucocutaneous Manifestations Associated with Inflammatory Bowel Disease: Diagnostic and Therapeutic Implications
  1. Home /
  2. Archives /
  3. Vol. 95 (2026) /
  4. Medical Sciences

Selected Cutaneous and Mucocutaneous Manifestations Associated with Inflammatory Bowel Disease: Diagnostic and Therapeutic Implications

Authors

  • Magda Marciniak Polska https://orcid.org/0009-0005-4016-6536
  • Sviatlana Filitaryna https://orcid.org/0009-0003-8897-0254
  • Monika Wiatr https://orcid.org/0009-0000-2038-3174
  • Cezary Orzechowski https://orcid.org/0009-0008-1265-311X
  • Michał Gutowski https://orcid.org/0009-0006-7865-8736
  • Monika Kałwak https://orcid.org/0009-0000-4244-3086
  • Aleksandra Foryś https://orcid.org/0009-0008-7983-1443
  • Wojciech Wojas https://orcid.org/0009-0007-4295-0599
  • Justyna Żabicka https://orcid.org/0009-0002-0612-0938
  • Kinga Lichtarska https://orcid.org/0009-0004-9319-8323
  • Patryk Dłubis https://orcid.org/0009-0009-2952-6675

DOI:

https://doi.org/10.12775/JEHS.2026.95.73808

Keywords

Inflammatory Bowel Diseases; Crohn Disease; Colitis, Ulcerative; Skin Diseases; Erythema Nodosum; Pyoderma Gangrenosum

Abstract

Abstract

Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis, comprises chronic inflammatory disorders of the gastrointestinal tract. In addition to intestinal symptoms, IBD may be accompanied by numerous extraintestinal manifestations, including cutaneous and mucocutaneous lesions. The most commonly reported dermatological manifestations include erythema nodosum, pyoderma gangrenosum, and oral lesions associated with Crohn’s disease. Cutaneous manifestations may precede the diagnosis of IBD; therefore, their recognition is important not only for dermatologists, but also for specialists in internal medicine and gastroenterology. Early identification of these manifestations may contribute to earlier diagnosis of the underlying disease and implementation of appropriate treatment. This review discusses selected, clinically relevant cutaneous and mucocutaneous manifestations in the course of IBD, with particular emphasis on their epidemiology, diagnostic criteria, clinical presentation, and therapeutic options.

References

References

1. Antonelli E, Bassotti G, Tramontana M, Hansel K, Stingeni L, Ardizzone S, Genovese G, Marzano AV, Maconi G. Dermatological Manifestations in Inflammatory Bowel Diseases. J Clin Med. 2021 Jan 19;10(2):364. doi: 10.3390/jcm10020364. PMID: 33477990; PMCID: PMC7835974.

2. Rogler G, Singh A, Kavanaugh A, Rubin DT. Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management. Gastroenterology. 2021 Oct;161(4):1118-1132. doi: 10.1053/j.gastro.2021.07.042. Epub 2021 Aug 3. PMID: 34358489; PMCID: PMC8564770.

3. Faggiani I, Fanizza J, D'Amico F, Allocca M, Zilli A, Parigi TL, Barchi A, Danese S, Furfaro F. Extraintestinal Manifestations in Inflammatory Bowel Disease: From Pathophysiology to Treatment. Biomedicines. 2024 Aug 13;12(8):1839. doi: 10.3390/biomedicines12081839. PMID: 39200303; PMCID: PMC11351332.

4. He R, Zhao S, Cui M, Chen Y, Ma J, Li J, Wang X. Cutaneous manifestations of inflammatory bowel disease: basic characteristics, therapy, and potential pathophysiological associations. Front Immunol. 2023 Oct 26;14:1234535. doi: 10.3389/fimmu.2023.1234535. PMID: 37954590; PMCID: PMC10637386.

5. Pellicer Z, Santiago JM, Rodriguez A, Alonso V, Antón R, Bosca MM. Management of cutaneous disorders related to inflammatory bowel disease. Ann Gastroenterol. 2012;25(1):21-26. PMID: 24713996; PMCID: PMC3959344.

6. Ungureanu L, Cosgarea R, Alexandru Badea M, Florentina Vasilovici A, Cosgarea I, Corina Șenilă S. Cutaneous manifestations in inflammatory bowel disease (Review). Exp Ther Med. 2020 Jul;20(1):31-37. doi: 10.3892/etm.2019.8321. Epub 2019 Dec 12. PMID: 32508989; PMCID: PMC7271697.

7. Hung YT, Le PH, Kuo CJ, Tang YC, Chiou MJ, Chiu CT, Kuo CF, Huang YH. The Temporal Relationships and Associations between Cutaneous Manifestations and Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study. J Clin Med. 2021 Mar 22;10(6):1311. doi: 10.3390/jcm10061311. PMID: 33810197; PMCID: PMC8004605.

8. Fedor I, Zold E, Barta Z. Temporal Relationship of Extraintestinal Manifestations in Inflammatory Bowel Disease. J Clin Med. 2021 Dec 20;10(24):5984. doi: 10.3390/jcm10245984. PMID: 34945280; PMCID: PMC8708470.

9. Malik TF, Aurelio DM. Extraintestinal Manifestations of Inflammatory Bowel Disease. 2023 Mar 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. PMID: 33760556.

10. Aberumand B, Howard J, Howard J. Metastatic Crohn's Disease: An Approach to an Uncommon but Important Cutaneous Disorder. Biomed Res Int. 2017;2017:8192150. doi: 10.1155/2017/8192150. Epub 2017 Jan 3. PMID: 28127561; PMCID: PMC5239966.

11. Pecci-Lloret MP, Ramirez-Santisteban E, Hergueta-Castillo A, Guerrero-Gironés J, Oñate-Sánchez RE. Oral Manifestations of Crohn's Disease: A Systematic Review. J Clin Med. 2023 Oct 10;12(20):6450. doi: 10.3390/jcm12206450. PMID: 37892587; PMCID: PMC10607549.

12. Downey K, Zhang R, Ortega-Loayza AG. Pyoderma Gangrenosum and Inflammatory Bowel Disease: Recent Insights into Epidemiology, Pathogenesis, and Therapeutic Approaches. J Inflamm Res. 2025 Nov 12;18:15859-15873. doi: 10.2147/JIR.S540840. PMID: 41255587; PMCID: PMC12620507.

13. Sasson S, Kalisky I, Rosenfeld G, Kiow JLC, Bressler B. Erythema nodosum as a marker for objective disease activity in inflammatory bowel disease. Crohns Colitis 360. 2026 Feb 20;8(1):otag013. doi: 10.1093/crocol/otag013. PMID: 41788361; PMCID: PMC12958114.

14. Rahvar M, Kerstetter J. Cutaneous manifestation of gastrointestinal disease. J Gastrointest Oncol. 2016 Apr;7(Suppl 1):S44-54. doi: 10.3978/j.issn.2078-6891.2015.059. PMID: 27034812; PMCID: PMC4783618.

15. Firek A, Warren K, Lorenzen C, Bonilla Md LP. Pyoderma Gangrenosum in Inflammatory Bowel Disease: A Rare Case Involving Mandibular, Elbow, and Pubic Ulcers. J Brown Hosp Med. 2024 Jan 1;3(1):90522. doi: 10.56305/001c.90522. PMID: 40027386; PMCID: PMC11864381.

16. Sleiman J, Hitawala AA, Cohen B, Falloon K, Simonson M, Click B, Khanna U, Fernandez AP, Rieder F. Systematic Review: Sweet Syndrome Associated with Inflammatory Bowel Disease. J Crohns Colitis. 2021 Nov 8;15(11):1864-1876. doi: 10.1093/ecco-jcc/jjab079. PMID: 33891004; PMCID: PMC8675328.

17. Sleiman J, Patel M, Khan MZ, Falloon K, Cohen B, Click B, Khanna U, Fernandez AP, Rieder F. Sweet Syndrome Associated with Active Inflammatory Bowel Disease: A Case Series of a Rare Extra-intestinal Manifestation. Dig Dis Sci. 2023 Sep;68(9):3562-3568. doi: 10.1007/s10620-023-07983-5. Epub 2023 Jul 5. PMID: 37402983; PMCID: PMC10921822.

18. Chrcanovic BR, Martins-Chaves RR, Pontes FSC, Fonseca FP, Pontes HAR, Gomez RS. Pyodermatitis-pyostomatitis vegetans: a case report and systematic review focusing on oral involvement. Oral Maxillofac Surg. 2024 Sep;28(3):1405-1414. doi: 10.1007/s10006-024-01234-1. Epub 2024 Mar 12. PMID: 38467949; PMCID: PMC11330387.

19. Bezzio C, Cavalli CAM, Franchellucci G, Dal Buono A, Gabbiadini R, Scalvini D, Manara S, Narcisi A, Armuzzi A, Saibeni S. Psoriasis and inflammatory bowel disease: concomitant IMID or paradoxical therapeutic effect? A scoping review on anti-IL-12/23 and anti-IL-23 antibodies. Ther Adv Gastroenterol. 2024 Nov 21;17:17562848241299564. doi: 10.1177/17562848241299564. PMID: 39575159; PMCID: PMC11580083.

20. Fu Y, Lee CH, Chi CC. Association of Psoriasis With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. JAMA Dermatol. 2018 Dec 1;154(12):1417-1423. doi: 10.1001/jamadermatol.2018.3631. PMID: 30422277; PMCID: PMC6583370.

21. Nehring P, Przybyłkowski A. Is Psoriasis Treatment a Risk Factor for Inflammatory Bowel Disease? Pharmaceut Med. 2020 Aug;34(4):257-262. doi: 10.1007/s40290-020-00340-1. PMID: 32514931; PMCID: PMC7427703.

22. Zouboulis CC, Desai N, Emtestam L, Hunger RE, Ioannides D, Juhász I, Lapins J, Matusiak L, Prens EP, Revuz J, Schneider-Burrus S, Szepietowski JC, van der Zee HH, Jemec GB. European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa. J Eur Acad Dermatol Venereol. 2015 Apr;29(4):619-44. doi: 10.1111/jdv.12966. Epub 2015 Jan 30. PMID: 25640693.

23. Mpakogiannis K, Fousekis FS, Karampinis E, Mastoridou E, Gaitanis G, Katsanos KH. Unravelling the Link Between Hidradenitis Suppurativa and Inflammatory Bowel Disease: A Literature Review. Biomedicines. 2025 Jul 27;13(8):1833. doi: 10.3390/biomedicines13081833. PMID: 40868088; PMCID: PMC12383343.

24. Chen WT, Chi CC. Association of Hidradenitis Suppurativa With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. JAMA Dermatol. 2019 Sep 1;155(9):1022-1027. doi: 10.1001/jamadermatol.2019.0891. PMID: 31290938; PMCID: PMC6625071.

25. Phan K, Tatian A, Woods J, Cains G, Frew JW. Prevalence of inflammatory bowel disease (IBD) in hidradenitis suppurativa (HS): systematic review and adjusted meta-analysis. Int J Dermatol. 2020 Feb;59(2):221-228. doi: 10.1111/ijd.14697. Epub 2019 Oct 20. PMID: 31631340.

26. Garg A, Hsiao J, Porter ML, Shi V. Current Treatments and Future Directions for Hidradenitis Suppurativa: a Narrative Review of Completed and Ongoing Phase 3 Clinical Trials of Biologic Therapies. Dermatol Ther (Heidelb). 2025 Sep;15(9):2361-2377. doi: 10.1007/s13555-025-01487-y. Epub 2025 Jul 18. PMID: 40681937; PMCID: PMC12354412.

27. Lambert JLW, De Schepper S, Speeckaert R. Cutaneous Manifestations in Biological-Treated Inflammatory Bowel Disease Patients: A Narrative Review. J Clin Med. 2021 Mar 3;10(5):1040. doi: 10.3390/jcm10051040. PMID: 33802483; PMCID: PMC7959457.

28. Wong CY, Chu DH. Cutaneous signs of nutritional disorders. Int J Womens Dermatol. 2021 Sep 22;7(5Part A):647-652. doi: 10.1016/j.ijwd.2021.09.003. PMID: 35024418; PMCID: PMC8721081.

Journal of Education, Health and Sport

Downloads

  • PDF

Published

2026-09-11

How to Cite

1.
MARCINIAK, Magda, FILITARYNA, Sviatlana, WIATR, Monika, ORZECHOWSKI, Cezary, GUTOWSKI, Michał, KAŁWAK, Monika, FORYŚ, Aleksandra, WOJAS, Wojciech, ŻABICKA, Justyna, LICHTARSKA, Kinga and DŁUBIS, Patryk. Selected Cutaneous and Mucocutaneous Manifestations Associated with Inflammatory Bowel Disease: Diagnostic and Therapeutic Implications. Journal of Education, Health and Sport. Online. 11 September 2026. Vol. 95, p. 73808. [Accessed 17 September 2026]. DOI 10.12775/JEHS.2026.95.73808.
  • ISO 690
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
Download Citation
  • Endnote/Zotero/Mendeley (RIS)
  • BibTeX

Issue

Vol. 95 (2026)

Section

Medical Sciences

License

Copyright (c) 2026 Magda Marciniak, Sviatlana Filitaryna, Monika Wiatr, Cezary Orzechowski, Michał Gutowski, Monika Kałwak, Aleksandra Foryś, Wojciech Wojas, Justyna Żabicka, Kinga Lichtarska, Patryk Dłubis

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

Stats

Number of views and downloads: 818
Number of citations: 0

Search

Search

Browse

  • Issue archive

User

User

Current Issue

  • Atom logo
  • RSS2 logo
  • RSS1 logo

Information

  • For Readers
  • For Authors
  • For Librarians

Newsletter

Subscribe Unsubscribe

Tags

Search using one of provided tags:

Inflammatory Bowel Diseases; Crohn Disease; Colitis, Ulcerative; Skin Diseases; Erythema Nodosum; Pyoderma Gangrenosum
Up

Akademicka Platforma Czasopism

Najlepsze czasopisma naukowe i akademickie w jednym miejscu

apcz.umk.pl

Partners

  • Akademia Ignatianum w Krakowie
  • Akademickie Towarzystwo Andragogiczne
  • Fundacja Copernicus na rzecz Rozwoju Badań Naukowych
  • Instytut Historii im. Tadeusza Manteuffla Polskiej Akademii Nauk
  • Instytut Kultur Śródziemnomorskich i Orientalnych PAN
  • Instytut Tomistyczny
  • Karmelitański Instytut Duchowości w Krakowie
  • Ministerstwo Kultury i Dziedzictwa Narodowego
  • Państwowa Akademia Nauk Stosowanych w Krośnie
  • Państwowa Akademia Nauk Stosowanych we Włocławku
  • Państwowa Wyższa Szkoła Zawodowa im. Stanisława Pigonia w Krośnie
  • Polska Fundacja Przemysłu Kosmicznego
  • Polskie Towarzystwo Ekonomiczne
  • Polskie Towarzystwo Ludoznawcze
  • Towarzystwo Miłośników Torunia
  • Towarzystwo Naukowe w Toruniu
  • Uniwersytet im. Adama Mickiewicza w Poznaniu
  • Uniwersytet Komisji Edukacji Narodowej w Krakowie
  • Uniwersytet Mikołaja Kopernika
  • Uniwersytet w Białymstoku
  • Uniwersytet Warszawski
  • Wojewódzka Biblioteka Publiczna - Książnica Kopernikańska
  • Wyższe Seminarium Duchowne w Pelplinie / Wydawnictwo Diecezjalne „Bernardinum" w Pelplinie

© 2021- Nicolaus Copernicus University Accessibility statement Shop