Disruptions in the interferonogenesis system in acute herpetic stomatitis in children and their impact on the condition of the dental and oral system
DOI:
https://doi.org/10.12775/JEHS.2026.93.73785Keywords
acute herpetic stomatitis, children, interferonogenesis, interferon-α, interferon-γ, antiviral immunity, dentofacial system, malocclusions, orthodontics, orthodontic treatment, pediatric therapeutic dentistryAbstract
The article examines the features of interferonogenesis disorders in children with acute herpetic stomatitis and determines their significance in the development of antiviral immune deficiency. The relevance of the study is обусловed by the high prevalence of herpesvirus infection among the pediatric population, the frequent occurrence of oral mucosal lesions, and the important role of immunological mechanisms in the development and progression of the disease.
The results of the study showed that acute herpetic stomatitis is accompanied by significant disturbances in the functioning of the interferonogenesis system. A significant decrease in the level of interferon-α was found in children with acute herpetic stomatitis compared to healthy individuals. The degree of decrease in this indicator directly depended on the severity of the clinical course of the disease. The most pronounced changes were observed in children with severe forms of the pathology, which indicated the suppression of the mechanisms of the early antiviral response and insufficient efficiency of innate immune defense.
It has been proven that a decrease in IFN-α production negatively affects the body's ability to counteract viral invasion at the initial stages of the infectious process.
It has been proven that impaired interferonogenesis in acute herpetic stomatitis is a component of complex immunological changes that cover various links of innate and adaptive immunity. Insufficiency of interferon production is combined with changes in the subpopulation composition of lymphocytes, a violation of cytokine balance and a decrease in the functional activity of effector cells of antiviral protection.
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