Obesity and depression - a bidirectional relationship and clinical implications
DOI:
https://doi.org/10.12775/JEHS.2026.95.73660Keywords
Obesity, depression, eating disordersAbstract
Background: Obesity has become a global civilization-related disease and constitutes an independent risk factor for numerous somatic disorders. Obesity can contribute to depression through low self-esteem, body image concerns, and stigmatization, while depression and chronic stress may promote obesity through emotional eating and binge eating. Both conditions share biological mechanisms, including HPA axis dysregulation, elevated cortisol levels, and chronic inflammation. Effective management requires an interdisciplinary approach that combines weight-loss interventions with psychological treatment. Weight reduction is associated with improved mood and quality of life.
Aim: The aim of this narrative review is to analyze and synthesize the current state of knowledge regarding the relationship between obesity and depression. The paper seeks to identify the biological and psychological mechanisms linking both conditions, as well as to assess the impact of obesity on the risk of depression and, conversely, the impact of depressive disorders on the development and course of obesity.
Material and methods: A literature review of scientific publications available in databases (including Google Scholar) was conducted, analyzing data on adolescents and adults with respect to pathophysiological and behavioral mechanisms. The review includes 24 articles published between 2006 and 2025.
Results: Individuals with obesity have a 55% higher risk of developing depression, whereas patients with depression are 58% more likely to develop obesity. The prevalence of depression in the population of individuals with obesity is increased, and a modifying effect of sex is observed. Key mechanisms include dysregulation of the HPA axis, chronic inflammation, and disturbances in neurotransmission.
Conclusions: Effective treatment requires an integrated approach combining weight reduction with psychological interventions. Treatment of obesity may lead to an improvement in mood.
References
[1] Knyszyńska A., Bażydło M., Zabielska P., Karakiewicz B., Lubkowska A. Body composition and depression in people with metabolic syndrome aged over 55 years. Family Medicine & Primary Care Review. 2016;18(2):128-131. doi:10.5114/fmpcr.2016.43614.
[2] Jaruć A., Wierusz-Wysocka B., Bogdański P. Psychological aspects of eating and excessive body weight. Farmacja Współczesna. 2011;4:119-126. https://www.akademiamedycyny.pl/wp-content/uploads/2016/05/201103_Farmacja_006.pdf
[3] Kołakowska K. Obesity pandemic — in search of the most effective treatment methods. Biuletyn Głównej Biblioteki Lekarskiej. 2024;383:143-156. doi:10.2478/bgbl-2024-0028.
[4] Olszanecka-Glinianowicz M. Depression - cause or effect of obesity? Endokrynologia, Otyłość i Zaburzenia Przemiany Materii. 2008;4(2):78-85. https://journals.viamedica.pl/eoizpm/article/viewFile/26040/20850
[5] Suwalska J., Skibińska M., Łojko D., Bogdański P. The assessment of selected factors associated with the co-occurrence of overweight/obesity and symptoms of depression in a group of young women. Neuropsychiatria i Neuropsychologia. 2024;19(1-2):1-8. doi:10.5114/nan.2024.141884.
[6] Bąk-Sosnowska M., Białkowska M., Bogdański P., Chomiuk T., Dobrowolski P., Gałązka-Sobotka M., Holecki M. Clinical recommendations for the management of patients with obesity 2024. Position of the Polish Society for the Treatment of Obesity. Medycyna Praktyczna. 2024;1:1-116. https://bazawiedzy.wsb.edu.pl/info/article/AWSBbb7adb5556154d60b424b92491392764/
[7] Borgland S.L. Can treatment of obesity reduce depression or vice versa? Journal of Psychiatry and Neuroscience. 2021;46(4):E411-E414. doi:10.1503/jpn.210036.
[8] Atlantis E., Goldney R.D., Wittert G.A. Obesity and depression or anxiety. BMJ. 2009;339:b3868. doi:10.1136/bmj.b3868.
[9] Tzenios N., Tazanios M.E., Chahine M., Jamal P.O.B. The complex relationship between obesity and depression. Specialty Journal of Medical and Academic Other Life Sciences. 2023;1(3). doi:10.58676/sjmas.v1i3.22.
[10] Villagrasa Blasco B., García-Jiménez J., Bodoano I., Gutiérrez-Rojas L. Obesity and depression: its prevalence and influence as a prognostic factor. A systematic review. Psychiatry Investigation. 2020;17(8):715-724. doi:10.30773/pi.2020.0099.
[11] Jośko-Ochojska J., Lizończyk I. Occurrence of depression in overweight and obese adolescents. Hygeia Public Health. 2014;49(4):690-695. http://www.h-ph.pl/pdf/hyg-2014/hyg-2014-4-690.pdf
[12] Derkacz M., Chmiel-Perzyńska I., Marczewski K. Obesity as an interdisciplinary medical problem. Part II. Effect on human health. Medycyna Ogólna. 2010;16(2):175-183. https://www.monz.pl/Otylosc-jako-interdyscyplinarny-problem-medyczny-Czesc-II-Wplyw-otylosci-na-zdrowie-czlowieka,73203,0,2.html
[13] Ha H., Han C., Kim B. Can obesity cause depression? A pseudo-panel analysis. Journal of Preventive Medicine and Public Health. 2017;50(4):262-267. doi:10.3961/jpmph.17.067.
[14] Pietrzykowska E., Wierusz-Wysocka B. Psychological aspects of overweight, obesity and slimming. Polski Merkuriusz Lekarski. 2008;24(143):472-476. https://janiszewska.com/wp-content/uploads/2016/10/Psychologiczne-aspekty-nadwagi-i-otyłości.pdf
[15] Kosatka D., Sobów T., Strzelczyk J. Frequency and severity of depression in obese individuals after surgical treatment of obesity using the RYGB method. Wiadomości Lekarskie. 2006;59(7-8):477-480.
[16] Brytek-Matera A., Charzyńska E. Cognitive and behavioral determinants of eating disorders in women with obesity. Endokrynologia, Otyłość i Zaburzenia Przemiany Materii. 2009;5(2):45-50. https://journals.viamedica.pl/eoizpm/article/download/26016/20826
[17] Bertrandt K. Self-assessment vs. quality of life and occurrence of depression symptoms among overweight and obese persons in comparison to persons of normal weight. Problemy Higieny i Epidemiologii. 2011;92(4):783-787. http://www.phie.pl/pdf/phe-2011/phe-2011-4-783.pdf
[18] Gębska-Kurczewska A., Wysocki M.J., Supranowicz P., Supranowicz T. Depression vs. overweight and perceived body appearance among adolescents living in suburban areas. Roczniki Państwowego Zakładu Higieny. 2011;62(4):427-431. https://bibliotekanauki.pl/articles/876964.pdf
[19] Kalinowski J., Kokociński S., Peszko M., Owecki M. The relationship of compulsive eating with obesity. Postępy Biologii Komórki. 2025;52(2):41-54. doi:10.59674/pbk25.
[20] Bąk-Sosnowska M. Eating disorders accompanying obesity. Forum Zaburzeń Metabolicznych. 2010;1(2):92-99. https://journals.viamedica.pl/forum_leczenia_otylosci/article/view/28727
[21] Fulton S., Décarie-Spain L., Fioramonti X., Guiard B., Nakajima S. The menace of obesity to depression and anxiety prevalence. Trends in Endocrinology and Metabolism. 2022;33(1):18-35. doi:10.1016/j.tem.2021.10.005.
[22] Hryhorczuk C., Sharma S., Fulton S.E. Metabolic disturbances connecting obesity and depression. Frontiers in Neuroscience. 2013;7:177. doi:10.3389/fnins.2013.00177.
[23] Buzuk G.A. Investigation of the relationship of overweight and obesity with the clinical picture of selected types of depression [doctoral dissertation]. Poznań: Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; 2014. https://www.wbc.poznan.pl/Content/347497/index.pdf
[24] Agarwal A., Agarwal M., Garg K., Dalal P.K., Trivedi J.K., Srivastava J.S. Metabolic syndrome and central obesity in depression: a cross-sectional study. Indian Journal of Psychiatry. 2016;58(3):281-286. doi:10.4103/0019-5545.192021.
[25] Katsi V, Koutsopoulos G, Fragoulis C, Dimitriadis K, Tsioufis K. Retatrutide-A Game Changer in Obesity Pharmacotherapy. Biomolecules. 2025;15(6):796. Published 2025 May 30. doi:10.3390/biom15060796
[26] Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022;387(3):205-216. doi:10.1056/NEJMoa2206038
[27] Filanowicz, M., i Gołdyn, A. (2023). Stany depresyjne w chorobie Leśniowskiego-Crohna. W: B. Jankowiak, B. Kowalewska i E. Krajewska-Kułak (red.), Promocja, edukacja zdrowotna oraz profilaktyka w naukach medycznych (t. 10, s. 141–149). Uniwersytet Medyczny w Białymstoku
https://www.umb.edu.pl/wnoz/o_wydziale/monografie_pracownikow_wnz
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Copyright (c) 2026 Adrian Kubicki, Małgorzata Maj, Natalia Niderla, Jakub Rzeszutek, Natalia Rochwał, Weronika Grzyb, Michał Kurnik, Adrianna Jaślikowska, Dominika Grzybowska, Kamil Idzik
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