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Journal of Education, Health and Sport

Pharmacotherapy of depression in palliative patients
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Pharmacotherapy of depression in palliative patients

Authors

  • Paulina Trawka Faculty of Health Sciences, Department and Clinic of Geriatrics, Nicolaus Copernicus University, Bydgoszcz
  • Aleksandra Paszkowska Faculty of Health Sciences, Department and Clinic of Geriatrics, Nicolaus Copernicus University, Bydgoszcz
  • Magdalena Lamch Faculty of Health Sciences, Department and Clinic of Geriatrics, Nicolaus Copernicus University, Bydgoszcz
  • Aleksandra Wijata Faculty of Health Sciences, Department and Clinic of Geriatrics, Nicolaus Copernicus University, Bydgoszcz
  • Paweł Hejnosz Faculty of Health Sciences, Department and Clinic of Geriatrics, Nicolaus Copernicus University, Bydgoszcz
  • Karolina Graczykowska Faculty of Health Sciences, Department and Clinic of Geriatrics, Nicolaus Copernicus University, Bydgoszcz
  • Magdalena Julia Jabłońska Faculty of Health Sciences, Department and Clinic of Geriatrics, Nicolaus Copernicus University, Bydgoszcz
  • Jakub Dorobiała Faculty of Health Sciences, Department and Clinic of Geriatrics, Nicolaus Copernicus University, Bydgoszcz
  • Maciej Lazarek Faculty of Health Sciences, Department and Clinic of Geriatrics, Nicolaus Copernicus University, Bydgoszcz
  • Michał Denkiewicz Faculty of Health Sciences, Department and Clinic of Geriatrics, Nicolaus Copernicus University, Bydgoszcz
  • Kornelia Kędziora-Kornatowska Faculty of Health Sciences, Department and Clinic of Geriatrics, Nicolaus Copernicus University, Bydgoszcz

Keywords

depression, palliative patients, sluggish serotonin reuptake inhibitors, SSRI, tricyclic antidepressants, TCA

Abstract

Introduction: Depression often affects people suffering from serious illnesses, including oncological and palliative patients. It reduces their quality of life and worsens their prognosis. This is why it is so important to properly treat depression in palliative patients. Material and Methods: The information provided was collected as a result of analysis of various articles and textbooks on development, diagnosis and treatment, as well as prevention of depression in terminally ill patients using Google Scholar and PubMed databases. Results: The results show that the most common drug in therapy for palliative patients with depression are the sluggish serotonin reuptake inhibitors (SSRIs). SSRIs inhibit serotonin transporter reducing serotonin reuptake. This raises the level of neurotransmitter - serotonin - in the synaptic cleft. They are well tolerated and have fewer side effects than older antidepressants (tricyclic antidepressants and monoamine oxidase inhibitors). Tricyclic antidepressants may relieve neuropathic pain and they are also beneficial for patients with insomnia. Mirtazapine in addition to antidepressant effects also causes increasing appetite, reducing nausea and sedative effect. In cancer-diagnosed patients particular attention should be paid to side effects such as nausea and vomiting that may occur in patients undergoing radiotherapy and chemotherapy using SSRIs or TCAs. SSRI therapy have a good safety profile and also interacts less frequently, while atypical antipsychotics may reduce the discomforts of taking chemotherapy. An alternative method of treating depression is the use of psychostimulants such as methylphenidate. Another way to treat depression is psychotherapy. Conclusions: There are several options for treating depression in palliative patients. It is important to pay attention to the side effects of prescribed medicines. Nevertheless, the best results are obtained by combining pharmacotherapy with psychotherapy.

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Published

2019-08-20

How to Cite

1.
TRAWKA, Paulina, PASZKOWSKA, Aleksandra, LAMCH, Magdalena, WIJATA, Aleksandra, HEJNOSZ, Paweł, GRACZYKOWSKA, Karolina, JABŁOŃSKA, Magdalena Julia, DOROBIAŁA, Jakub, LAZAREK, Maciej, DENKIEWICZ, Michał & KĘDZIORA-KORNATOWSKA, Kornelia. Pharmacotherapy of depression in palliative patients. Journal of Education, Health and Sport [online]. 20 August 2019, T. 9, nr 9, s. 27–37. [accessed 2.4.2023].
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Vol. 9 No. 9 (2019)

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Articles

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The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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