Biosynthetic classification of flavanoids (vitamins P)
DOI:
https://doi.org/10.12775/JEHS.2026.90.72374Keywords
flavonoids, vitamin P, biogenesis, classificationAbstract
Annotation
The vast number of compounds based on the three-membered flavan ring and possessing vitamin P activity requires a specific systematization of flavanoids. Existing classifications, unfortunately, do not take into account the full diversity of these compounds, including their biogenesis.
We have proposed a classification of flavonoids with P-vitamin activity that takes into account their biosynthesis and interconversions. This so-called biosynthetic classification divides all flavonoids into 11 classes: 1 – chalcones, 2 – flavanones, 3 – flavanols, 4 – flavones, 5 – isoflavones, 6 – dihydroflavanol, 7 – flavon-3-ols, 8 – flavandiols (leucoanthocyanidins), 9 – anthocyanidins, 10 – flavan-lignans, 11 – atypical and modified flavanoids.
References
1. Bentsáth A, Rusznyák St, Szent-Györgyi A. Vitamin nature of flavones. Nature. 1936;138:798.
2. Bentsáth A, Szent-Györgyi A. Vitamin P. Nature. 1937;140:426.
3. Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients. 2010;2(12):1231-1246. doi: 10.3390/nu2121231
4. Corradini E, Foglia P, Giansanti P, Gubbiotti R, Samperi R, Laganà A. Flavonoids: chemical properties and analytical methodologies of identification and quantitation in foods and plants. Natural Product Research. 2011;25(5):469-495. https://doi.org/10.1080/14786419.2010.482054
5. García-Calderón M, Pérez-Delgado CM, Palove-Balang P, Betti M, Márquez AJ. Flavonoids and Isoflavonoids Biosynthesis in the Model Legume Lotus japonicus; Connections to Nitrogen Metabolism and Photorespiration. Plants (Basel). 2020;9(6):774. doi: 10.3390/plants9060774.
6. Liga S, Paul C, Péter F. Flavonoids: overview of biosynthesis, biological activity, and current extraction techniques. Plants (Basel). 2023;12(14):2732. https://doi: 10.3390/plants12142732
7. Mojbenko AA (editor). Bioflavonoids as organ protectors. Quercetin, corvitin, quertin. Kiev, Naukova dumka, 2012:274. (in Russian)
8. Giamperi L, Fraternale D, Bucchini A, Ricci D. Antioxidant activity of Citrus paradisi seeds glyceric extract. Fitoterapia. 2004;75(2):221-224. doi: 10.1016/j.fitote.2003.12.010.
9. Chervjakovskij EM, Kurchenko VP, Kostjuk EA. The role of flavonoids in biological reactions with electron transfer. Proceedings of the Belarusian State University. 2009;4(I). (in Russian)
10. Umeno A, Horie M, Murotomi K, Nakajima Y, Yoshida Y. Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones. Molecules.2016;21(6):708. DOI: 10.3390/molecules21060708
11. Rudrapal M, Khan J, Dukhyil AAB, Alarousy RMII, Attah EI, Sharma T, Khairnar SJ, Bendale AR. Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics. Molecules. 2021;26(23):7177. doi: 10.3390/molecules26237177
12. Маkаrеnkо O, Levitsky A. Biochemical mechanisms of therapeutic and prophylactic effects of bioflavonoids. J Pharm Pharmacol. 2016;4(8):451-456. https://doi: 10.17265/2328-2150/2016.08.013
13. Yahfoufi N, Alsadi N, Jambi M, Matar C. The Immunomodulatory and Anti-Inflammatory Role of Polyphenols. Nutrients. 2018;10(11):1618. doi: 10.3390/nu10111618
14. Abe I, Morita H. Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases. Nat Prod Rep. 2010;27(6):809-838. doi: 10.1039/b909988n
15. Cheng AX, Han XJ, Wu YF, Lou HX. The function and catalysis of 2-oxoglutarate-dependent oxygenases involved in plant flavonoid biosynthesis. Int. J. Mol. Sci. 2014;15:1080-1095. doi: 10.3390/ijms15011080
16. Santos EL, Maia BHLNS, Ferriani AP, Teixeira SD. Flavonoids: Classification, Biosynthesis and Chemical Ecology [Internet]. Flavonoids - From Biosynthesis to Human Health. InTech; 2017. https://doi.org/10.5772/67861
17. Martinez RM, Pinho-Ribeiro FA, Steffen VS, Caviglione CV, Fattori V, Bussmann AJC, Bottura C, Fonseca MJV, Vignoli JA, Baracat MM, Georgetti SR, Verri WA, Casagrande R. Trans-Chalcone, a flavonoid precursor, inhibits UV-induced skin inflammation and oxidative stress in mice by targeting NADPH oxidase and cytokine production. Photochem. Photobiol. Sci. 2017;16:1162-1173. DOI https://doi.org/10.1039/C6PP00442C
18. Sandoval V, Sanz-Lamora H, Arias G, Marrero PF, Haro D, Relat J. Metabolic Impact of Flavonoids Consumptionin Obesity: From Central to Peripheral. Nutrients. 2020;12:2393. doi:10.3390/nu12082393
19. König A, Sadova N, Dornmayr M, Schwarzinger B, Neuhauser C, Stadlbauer V, Wallner M, Woischitzschläger J, Müller A, Tona R, Kofel D, Weghuber J. Combined acid hydrolysis and fermentation improves bioactivity of citrus flavonoids in vitro and in vivo. Communications Biology. 2023;6:1083. https://doi.org/10.1038/s42003-023-05424-7
20. Levitsky AP, Malinovskii VA. Structural classification of vitamins P. Journal of Education, Health and Sport. 2025;83:64284. https://dx.doi.org/10.12775/JEHS.2025.83.64284
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