Determination of biochemical indicators when modeling HIPEC with cisplatin on rats

Authors

  • E. D. Pykhtieieva Ukrainian Research Institute of Transport Medicine
  • A. M. Tretyakov Ukrainian Research Institute of Transport Medicine
  • A. I. Gozhenko Ukrainian Research Institute of Transport Medicine
  • E. G. Pykhtieieva Ukrainian Research Institute of Transport Medicine

Keywords

rats, cisplatin, temperature, acid phosphatase, lipid peroxidation, creatinine

Abstract

HIPEC (Hyperthermic intraperitoneal chemotherapy; hyperthermic intraoperative intraperitoneally chemoperfusion) is a method of treating primary and secondary peritoneal tumors. Perfusion of the peritoneal cavity with solutions with cytotoxic agents at a temperature above the physiological norm (41-43 ° C) occurs when HIPEC. The conducted biochemical studies suggest that with HIPEC, elevated temperature is an important factor and leads to potentiation of the toxic effect of cisplatin. Despite the higher accumulation of platinum in the kidneys during cold solution perfusion, the resulting change in biochemical parameters is higher with the simultaneous action of elevated temperature and cisplatin.

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Published

2019-03-29

How to Cite

1.
PYKHTIEIEVA, E. D., TRETYAKOV, A. M., GOZHENKO, A. I. and PYKHTIEIEVA, E. G. Determination of biochemical indicators when modeling HIPEC with cisplatin on rats. Journal of Education, Health and Sport. Online. 29 March 2019. Vol. 9, no. 3, pp. 626-631. [Accessed 28 June 2025].

Issue

Vol. 9 No. 3 (2019)

Section

Research Articles

License

The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0

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