Sexual Dimorphism and Aging as Determinants of Serum Lipid Profiles and Cardiovascular Risk

Authors

DOI:

https://doi.org/10.12775/JEHS.2026.91.70887

Keywords

metabolism, cardiovascular, lipoprotein, aging, dyslipidemia

Abstract

The complex variability of circulating blood lipid profiles serves as a fundamental physiological indicator for the onset and progression of numerous metabolic and chronic conditions. It is clinically well-established that dyslipidemia—a multifaceted metabolic state characterized by pathologically elevated lipid concentrations—functions as a primary driver in the pathogenesis of atherosclerosis and subsequent cardiovascular disease. Given that the systematic reduction of these lipid fractions, whether through pharmacological intervention or lifestyle modification, can drastically improve a patient’s long-term cardiovascular prognosis, a nuanced understanding of lipid distribution is critical for effective clinical management.

 

This review provides a comprehensive analysis of the various biological determinants that govern these fluctuations, with a particular emphasis on the distinct roles of sex-based hormonal profiles and age-related physiological shifts. By examining the interplay between these factors, we aim to elucidate how they independently and synergistically influence the serum concentrations of triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol. Furthermore, the discussion explores how these demographic variables modulate the metabolic pathways responsible for both the accumulation of pro-atherogenic particles and the efficiency of reverse cholesterol transport, ultimately shaping an individual's overall cardiovascular risk profile.

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2026-05-23

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MAJCHRZAK, Mateusz, GRACZYK, Natalia, GRACZYK, Martyna, WISOKY, Wiktor, CZAPLA, Natalia, ZIÓŁKOWSKA, Weronika, STRÓŻYŃSKA, Ewelina, ŁOPIŃSKA, Joanna, MAJCHRZYCKA, Marta and IGNYŚ, Piotr. Sexual Dimorphism and Aging as Determinants of Serum Lipid Profiles and Cardiovascular Risk. Journal of Education, Health and Sport. Online. 23 May 2026. Vol. 91, p. 70887. [Accessed 24 May 2026]. DOI 10.12775/JEHS.2026.91.70887.

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Copyright (c) 2026 Mateusz Majchrzak, Natalia Graczyk, Martyna Graczyk, Wiktor Wisoky, Natalia Czapla, Weronika Ziółkowska, Ewelina Stróżyńska, Joanna Łopińska, Marta Majchrzycka, Piotr Ignyś

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