Blood Flow Restriction Training in Postoperative Musculoskeletal Rehabilitation
DOI:
https://doi.org/10.12775/JEHS.2026.91.70722Keywords
Blood flow restriction training, musculoskeletal rehabilitation, ACL reconstruction, total knee arthroplastyAbstract
Background: Blood flow restriction (BFR) training applies partial vascular occlusion during low-load exercise, offering a clinically compelling adjunct in postoperative rehabilitation. It addresses the paradox of maintaining muscle mass when conventional high-load exercise is contraindicated.
Aim: To conduct a narrative review of BFR's mechanisms, efficacy, and safety in postoperative musculoskeletal disorders, emphasizing ACL reconstruction, total knee arthroplasty (TKA), rotator cuff, and meniscal surgery.
Material and Methods: A systematic search of PubMed, Web of Science, and Scopus was performed for English, peer-reviewed human studies published between January 2005 and March 2026. Included studies employed defined BFR protocols for perioperative or postoperative musculoskeletal rehabilitation.
Results: Based on 29 studies, BFR significantly mitigates quadriceps atrophy and accelerates strength recovery post-ACL reconstruction compared to load-matched controls. Its efficacy extends to TKA, rotator cuff, and meniscal procedures. Mechanisms include metabolic stress, mTORC1 activation, hormonal upregulation, and regenerative intercellular mitochondrial transfer. BFR is safe when utilizing individualised limb occlusion pressure (LOP) protocols.
Conclusions: BFR enables load-compromised patients to achieve resistance training adaptations previously requiring high intensities. Standardising protocols and conducting multicentre trials are priorities for evidence-based integration.
References
1. Loenneke JP, Wilson GJ, Wilson JM. A mechanistic approach to blood flow occlusion. Int J Sports Med. 2010;31(1):1-4. doi: 10.1055/s-0029-1239499. https://doi.org/10.1055/s-0029-1239499.
2. Hedt C, McCulloch PC, Harris JD, Lambert BS. Blood flow restriction enhances rehabilitation and return to sport: the paradox of proximal performance. Arthrosc Sports Med Rehabil. 2022;4(1):e51-e63. doi: 10.1016/j.asmr.2021.09.024. https://doi.org/10.1016/j.asmr.2021.09.024.
3. Scott BR, Loenneke JP, Slattery KM, Dascombe BJ. Blood flow restricted exercise for athletes: a review of available evidence. J Sci Med Sport. 2016;19(5):360-367. doi: 10.1016/j.jsams.2015.04.014. https://doi.org/10.1016/j.jsams.2015.04.014.
4. Yinghao L, Jing Y, Yongqi W, Jianming Z, Zeng G, Yiting T, et al. Effects of a blood flow restriction exercise under different pressures on testosterone, growth hormone, and insulin-like growth factor levels. J Int Med Res. 2021;49(9):3000605211039564. doi: 10.1177/03000605211039564. https://doi.org/10.1177/03000605211039564.
5. Sevinc C, Gürler V, Harput G, Ocguder A, Ergen FB, Tunay VB. Blood flow restriction training with cross education for quadriceps muscle recovery after anterior cruciate ligament reconstruction: a prospective, randomized, controlled, single-blind clinical trial. Knee Surg Sports Traumatol Arthrosc. 2025;33(9):3088-3097. https://doi.org/10.1002/ksa.12553.
6. Charles D, White R, Reyes C, Palmer D. A systematic review of the effects of blood flow restriction training on quadriceps muscle atrophy and circumference post ACL reconstruction. Int J Sports Phys Ther. 2020;15(6):882-891. doi: 10.26603/ijspt20200882. https://doi.org/10.26603/ijspt20200882.
7. Hughes L, Paton B, Rosenblatt B, Gissane C, Patterson SD. Blood flow restriction training in clinical musculoskeletal rehabilitation: a systematic review and meta-analysis. Br J Sports Med. 2017;51(13):1003-1011. doi: 10.1136/bjsports-2016-097071. https://doi.org/10.1136/bjsports-2016-097071.
8. Zhao B, Zhao W, Chen L, Wang B, Zhang L, Cheng A, et al. Comparative effectiveness of neuromuscular, virtual reality, proprioceptive, blood flow restriction and conventional training after ACL reconstruction: a network meta-analysis of randomized controlled trials. Knee Surg Sports Traumatol Arthrosc. 2026:1-22. doi: 10.1002/ksa.70345. https://doi.org/10.1002/ksa.70345.
9. Milan N, Wague A, Sang L, Youn A, Sadjadi R, Samimi Y, et al. Blood flow restriction therapy stimulates intercellular mitochondria transfer and improves muscle regeneration and shoulder function in a murine rotator cuff injury model. Am J Sports Med. 2026;54(5):1114-1125. doi: 10.1177/03635465261424875. https://doi.org/10.1177/03635465261424875.
10. Erickson LN, Lucas KCH, Davis KA, Jacobs CA, Thompson KL, Hardy PA, et al. Effect of blood flow restriction training on quadriceps muscle strength, morphology, physiology, and knee biomechanics before and after anterior cruciate ligament reconstruction: protocol for a randomized clinical trial. Phys Ther. 2019;99(8):1010-1019. doi: 10.1093/ptj/pzz062. https://doi.org/10.1093/ptj/pzz062.
11. Lauber B, König D, Gollhofer A, Centner C. Isometric blood flow restriction exercise: acute physiological and neuromuscular responses. BMC Sports Sci Med Rehabil. 2021;13(1):12. doi: 10.1186/s13102-021-00239-7. https://doi.org/10.1186/s13102-021-00239-7.
12. Wilkinson BG, Donnenwerth JJ, Peterson AR. Use of blood flow restriction training for postoperative rehabilitation. Curr Sports Med Rep. 2019;18(6):218-225.
13. Nascimento DDC, Rolnick N, Neto IVS, Severin R, Beal FLR. A useful blood flow restriction training risk stratification for exercise and rehabilitation. Front Physiol. 2022;13:808622. doi: 10.3389/fphys.2022.808622. https://doi.org/10.3389/fphys.2022.808622.
14. Anderson KD, Rask DMG, Bates TJ, Nuelle JAV. Overall safety and risks associated with blood flow restriction therapy: a literature review. Mil Med. 2022;187(9-10):1059-1064. doi: 10.1093/milmed/usac055. https://doi.org/10.1093/milmed/usac055.
15. Cristina-Oliveira M, Meireles K, Spranger MD, O'Leary DS, Roschel H, Peçanha T. Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise. Am J Physiol Heart Circ Physiol. 2020;318(1):H90-H109. doi: 10.1152/ajpheart.00468.2019. https://doi.org/10.1152/ajpheart.00468.2019.
16. Kong DH, Jung WS, Yang SJ, Kim JG, Park HY, Kim J. Effects of neuromuscular electrical stimulation and blood flow restriction in rehabilitation after anterior cruciate ligament reconstruction. Int J Environ Res Public Health. 2022;19(22):15041. doi: 10.3390/ijerph192215041. https://doi.org/10.3390/ijerph192215041.
17. Cutisque LP, Buckley JG, Felix Rodacki AL. Walking with blood flow restriction on lower limb muscles post-ACL reconstruction: a within-subject trial. PLoS One. 2025;20(10):e0333200. doi: 10.1371/journal.pone.0333200. https://doi.org/10.1371/journal.pone.0333200.
18. Franz A, Queitsch FP, Behringer M, Mayer C, Krauspe R, Zilkens C. Blood flow restriction training as a prehabilitation concept in total knee arthroplasty: a narrative review about current preoperative interventions and the potential impact of BFR. Med Hypotheses. 2018;110:53-59. doi: 10.1016/j.mehy.2017.10.029. https://doi.org/10.1016/j.mehy.2017.10.029.
19. Franz A, Ji S, Bittersohl B, Zilkens C, Behringer M. Impact of a six-week prehabilitation with blood-flow restriction training on pre- and postoperative skeletal muscle mass and strength in patients receiving primary total knee arthroplasty. Front Physiol. 2022;13:881484. doi: 10.3389/fphys.2022.881484. https://doi.org/10.3389/fphys.2022.881484.
20. Jørgensen SL, Aagaard P, Bohn MB, Hansen P, Hansen PM, Holm C, et al. The effect of blood flow restriction exercise prior to total knee arthroplasty on postoperative physical function, lower limb strength and patient-reported outcomes: a randomized controlled trial. Scand J Med Sci Sports. 2024;34(11):e14750. doi: 10.1111/sms.14750. https://doi.org/10.1111/sms.14750.
21. Tian X, Wang S, Zhou T, Zhao Q. Preoperative blood flow restriction training combined with postoperative continuous passive motion in elderly patients after total knee arthroplasty: study protocol for a randomized controlled trial. Trials. 2025;26(1):320. doi: 10.1186/s13063-025-09071-7. https://doi.org/10.1186/s13063-025-09071-7.
22. Caetano D, Oliveira C, Correia C, Barbosa P, Montes A, Carvalho P. Rehabilitation outcomes and parameters of blood flow restriction training in ACL injury: a scoping review. Phys Ther Sport. 2021;49:129-137. doi: 10.1016/j.ptsp.2021.01.015. https://doi.org/10.1016/j.ptsp.2021.01.015.
23. Colombo V, Valenčič T, Steiner K, Škarabot J, Folland J, O'Sullivan O, et al. Comparison of blood flow restriction interventions to standard rehabilitation after an anterior cruciate ligament injury: a systematic review. Am J Sports Med. 2024;52(14):3641-3650. doi: 10.1177/03635465241232002. https://doi.org/10.1177/03635465241232002.
24. Barzyk P, Fiedler C, Schlag M, Heitner A, Bender J, Paul J. Effect of blood flow restriction training in early postoperative rehabilitation after ACL reconstruction: a randomised controlled trial. Front Sports Act Living. 2026;7:1689257. doi: 10.3389/fspor.2025.1689257. https://doi.org/10.3389/fspor.2025.1689257.
25. Okoroha KR, Tramer JS, Khalil LS, Jildeh TR, Abbas MJ, Buckley PJ, et al. Effects of a perioperative blood flow restriction therapy program on early quadriceps strength and patient-reported outcomes after anterior cruciate ligament reconstruction. Orthop J Sports Med. 2023;11(11):23259671231209694. doi: 10.1177/23259671231209694. https://doi.org/10.1177/23259671231209694.
26. Lu Y, Patel BH, Kym C, Nwachukwu BU, Beletksy A, Forsythe B, et al. Perioperative blood flow restriction rehabilitation in patients undergoing ACL reconstruction: a systematic review. Orthop J Sports Med. 2020;8(3):2325967120906822. doi: 10.1177/2325967120906822. https://doi.org/10.1177/2325967120906822.
27. Kilgas MA, Lytle LLM, Drum SN, Elmer SJ. Exercise with blood flow restriction to improve quadriceps function long after ACL reconstruction. Int J Sports Med. 2019;40(10):650-656. doi: 10.1055/a-0961-1434. https://doi.org/10.1055/a-0961-1434.
28. Ceccarelli C, Andreani A, Soave A, Salomon M, Maselli F. Use of blood flow restriction for increasing the strength of the ischiocrural muscles in anterior cruciate ligament rehabilitation: a case report. Physiother Res Int. 2024;29(1):e2059. doi: 10.1002/pri.2059. https://doi.org/10.1002/pri.2059.
29. Tiss B, Layouni S, Ghali H, Ceylan Hİ, Nticha I, Jemni S, et al. Blood flow restriction training in knee arthroplasty: a systematic review of current evidence on postoperative muscle strength and function. Medicina (Kaunas). 2025;61(10):1879. doi: 10.3390/medicina61101879. https://doi.org/10.3390/medicina61101879.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Bartosz Rodziewicz, Mateusz Fidut, Mikołaj Kacperski

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 55
Number of citations: 0